N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2944-2947

  Amorelli, Benjamin ^a   Yang, Chunhua ^a   Rempel, Brian ^b   Withers, Stephen G ^b   Knapp, Spencer ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Glycosidase; O GlcNAcase; Pyranose conformation; Streptomyces plicatus; Transition state mimic

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CARBOHYDRATE DERIVATIVE; CARBON; HETEROCYCLIC COMPOUND; N ACETYLGALACTOSAMINE; N ACETYLGLUCOSAMINE; THIAZOLE DERIVATIVE;

ARTICLE; CRYSTALLOGRAPHY; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY;

BETA-N-ACETYLHEXOSAMINIDASES; BINDING SITES; CARBOHYDRATE SEQUENCE; CARBON; ENZYME INHIBITORS; GALACTOSE; GLUCOSAMINE; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PIPERIDINES; SUBSTRATE SPECIFICITY; THIAZOLES;

BACTERIA (MICROORGANISMS); SPHEX; STREPTOMYCES PLICATUS;

EID: 42949095576     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.067     Document Type: Article

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