Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy

Toxicology and Applied Pharmacology

Volumn 229, Issue 1, 2008, Pages 77-85

  Viquez, Olga M ^a   Valentine, Holly L ^a   Amarnath, Kalyani ^a   Milatovic, Dejan ^a   Valentine, William M ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Copper; Diethyldithiocarbamate; Lipid oxidation; Myelinopathy

Indexed keywords

4 HYDROXYNONENAL; COPPER; DIETHYLDITHIOCARBAMIC ACID; GLOBIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; ISOPROSTANE DERIVATIVE; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; ELECTRON MICROSCOPY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INFLAMMATION; LIPID OXIDATION; LIPID PEROXIDATION; LIVER; MACROPHAGE; MALE; MASS SPECTROMETRY; MYELIN SHEATH; NONHUMAN; OSMOTIC PUMP; OXIDATIVE STRESS; PERIPHERAL MYELINOPATHY; PERIPHERAL NEUROPATHY; RAT; SCIATIC NERVE; TIBIAL NERVE;

ANIMALS; BRAIN; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DITIOCARB; IMMUNOGLOBULIN G; LIPID PEROXIDATION; LIVER; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MALONDIALDEHYDE; MASS SPECTROMETRY; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TIBIAL NERVE;

ANIMALIA; RATTUS;

EID: 42749097263     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.01.005     Document Type: Article

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