Is Muta™Mouse insensitive to clastogens?

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 652, Issue 2, 2008, Pages 145-150

  Lynch, Anthony M ^a   Mahabir, Anuska G ^b,c   Bradford, Andrea ^a   Brockhurst, Kate ^a   van Benthem, Jan ^b   van Steeg, Harry ^b   Rees, Robert W ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Clastogens; Muta Mouse; Plasmid mouse

Indexed keywords

AMSACRINE; BENZO[A]PYRENE; BLEOMYCIN; CAMPTOTHECIN; CLASTOGEN; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; EXPERIMENTAL MODEL; FLOW CYTOMETRY; GENE MUTATION; GENOTOXICITY; KIDNEY; MALE; MICRONUCLEUS TEST; MOUSE; MOUSE MUTANT; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TISSUE SECTION; TRANSGENICS; ANIMAL; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; EVALUATION; LACTOSE OPERON; METHODOLOGY; MUTAGEN TESTING; TRANSGENIC MOUSE;

MUS;

AMSACRINE; ANIMALS; BLEOMYCIN; CAMPTOTHECIN; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; LAC OPERON; MALE; MICE; MICE, TRANSGENIC; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS;

EID: 42749094634     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.01.008     Document Type: Article

References (26)

1. Gossen J.A., de Leeuw W.J., Tan C.H., Zwarthoff E.C., Berends F., Lohman P.H., Knook D.L., and Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. PNAS (U.S.A.) 86 (1989) 7971-7975
2. Suzuki T., Hayashi M., Sofuni T., and Myhr B.C. The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice. Mut. Res. 285 (1993) 219-224
3. Suzuki T., Hayashi M., Wang X., Yamamoto K., Ono T., Myhr B., and Sofuni T. A comparison of the genotoxicity of ethylnitosourea and ethyl methanesulfonate in lacZ transgenic mice (Muta™Mouse). Mut. Res. 395 (1997) 75-82
4. Suzuki T., Miyata Y., Saeki K., Kawazoe Y., Hayashi M., and Sofuni T. In vivo mutagenesis by the hepatocarcinogen quinoline in the lacZ transgenic mouse: evidence for its in vivo toxicity. Mut. Res. 412 (1998) 161-166
5. Mahabir A.G., van Benthem J., Korsten H., Lynch A.M., de Vries A., Hendriksen C.F.M., and van Steeg H. Detecting the genotoxic effects of potential clastogens: an in vivo study using the lacZ plasmid and the Muta™Mouse model. Mut. Res. (2007) (this edition)
6. Schmid W. The micronucleus test for cytogenetic analysis. Chemical Mutagens. Principles and Methods for their Detection vol. 4 (1976), Plenum Press, New York pp. 31-53
7. Heddle J.A. The induction of micronuclei as a measure of genotoxicity Gene-tox program. Mut. Res. 123 (1983) 61-118
8. Dertinger S.D., Torous D.K., and Tometsko K.R. Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer. Mut. Res. 371 (1996) 283-292
9. Tometsko A.D., Torous D., and Dertinger S. Analysis of micronucleated cells by flow cytometry 1. Achieving high resolution with a malaria model. Mut. Res. 292 (1993) 129-135
10. Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50 (1955) 1096-1121
11. Nakajima M., Kikuchi M., Saeki K., Miyata Y., Terada M., Kishida F., Yamamoto R., Furihata C., and Dean S. Mutagenicity of 4-nitroquinoline 1-oxide in the Muta™Mouse. Mut. Res. 444 (1999) 321-336
12. Suzuki T., Itoh S., Nakajima M., and Hachiya N.H. Target organ and time-course in the mutagenicity of five carcinogens in the MutaMouse: a summary report of the second collaboratiuve study of the transgenic mouse mutation assay by JEMS/MMS. Mut. Res. 444 (1999) 259-268
13. Hakura A., Tsutsui Y., Sonoda J., Tsukidate K., Mikami T., and Sagami F. Comparison of the mutational spectra of the lacZ transgene in four organs of the MutaMouse treated with benzo[a]pyrene: target organ specificity. Mut. Res. 447 (2000) 239-247
14. Hakura A., Sonoda J., Tsutsui Y., Mikami T., Imade T., Shimada M., Yaguchi S., Yamanaka M., Tomimatsu M., and Tsukidate K. Toxicity profile of benzo[a]pyrene in the male LacZ transgenic mouse (MutaMouse) following oral administration for 5 consecutive days. Regul. Toxicol. Pharmacol. 27 (1998) 273-279
15. Povirk L.F., and Austin M.J.F. Genotoxicity of bleomycin. Mut. Res. 257 (1991) 127-143
16. Giri S.N., and Wang Q.J. Miscellaneous mediator systems in pulmonary fibrosis. Pulmonary Fibrosis (1995), Marcel Dekker, New York pp. 777-836
17. Hwang J., Shyy S., Chen A.Y., Juan C.C., and Whang-Peng J. Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide. Cancer Res. 49 (1989) 958-962
18. Backer L.C., Allen J.W., Harrington-Brock K., Campbell J.A., DeMarini D.M., Doerr C.L., Howard D.R., Kligerman A.D., and Moore M.M. Genotoxicity of inhibtiors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. Mutagenesis 5 (1990) 541-547
19. Hashimoto H., Chatterjee S., and Berger N.A. Mutagenic activity of topoisomerase I inhibitors. Clin. Cancer Res. 1 (1995) 369-376
20. Blakey D.H., Douglas G.R., Huang K.C., and Winter H.J. Cytogenetic mapping of lambda gt10 lacZ sequences in the transgenic mouse strain 40.6 (Muta Mouse). Mutagenesis 10 (1995) 145-148
21. Swiger R.R., Myhr B., and Tucker J.D. The LacZ transgene in MutaMouse maps to chromosome 3. Mut. Res. 325 (1994) 145-148
22. Gossen J.A., Martus H., Wei J.Y., and Vijg J. Spontaneous and X-ray-induced delection mutations in a LacZ plasmid-based transgenic mouse model. Mut. Res. 331 (1995) 89-97
23. Van Delft J.H., Bergmans A., van Dam F.J., Tates A.D., Howard L., Winton D.J., and Baan R.A. Gene-mutation assays in lambda lacZ transgenic mice: comparison of lacZ with endogenous genes in splenocytes and small intestine epithelium. Mut. Res. 415 (1998) 85-96
24. Gondo Y., Shioyama Y., Nakoa K., and Katsuki M. A novel positive detection system of the in vivo mutations in rpsL (strA) transgenic mice. Mut. Res. 360 (1996) 1-14
25. Thybaud V., Dean S., Nohmi T., de Boer J., Douglas G.R., Glickman B.W., Gorelick N.J., Heddle J.A., Heflich R.H., Lambert I., Martus H.J., Mirsalis J.C., Suzuki T., and Yajima N. In vivo transgenic mutation assays. Mut. Res 540 (1993) 141-151
26. DeMarini D.M., Doerr C.L., Meyer M.K., Brock K.H., Hozier J., and Moore M.M. Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanisms: possible role of topoisomerase. Mutagenesis 2 (1987) 349-355