Gene-mutation assays in λlacZ transgenic mice: Comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 415, Issue 1-2, 1998, Pages 85-96

  Van Delft, Joost H M ^a   Bergmans, Angela ^a   Van Dam, Fred J ^b   Tates, Ad D ^b   Howard, Louise ^c   Winton, Douglas J ^c   Baan, Robert A ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

lacZ; Dlb 1; hprt; Mutagenesis; Transgenic mouse

Indexed keywords

ETHYLNITROSOUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESYLIC ACID ETHYL ESTER; METHYLNITROSOUREA; MUTAGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE; GENE MUTATION; INTESTINE EPITHELIUM; MOUSE; MUTAGENESIS; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA; SPLEEN CELL; TRANSGENIC MOUSE;

ALKYLATING AGENTS; ANIMALS; ETHYL METHANESULFONATE; ETHYLNITROSOUREA; GENETIC MARKERS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTESTINAL MUCOSA; INTESTINE, SMALL; LAC OPERON; METHYLNITROSOUREA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENICITY TESTS; MUTAGENS; MUTATION; SPLEEN;

ANIMALIA; MUS MUSCULUS;

EID: 0031815614     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00063-1     Document Type: Article

References (32)

1. J.E. Cochrane, T.R. Skopek, Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene. 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from B6C3F1 mice, Carcinogenesis 15 (1994) 719-723.
2. A.D. Tates, F.J. van Dam, F.A. de Zwart, C.M.M. van Teylingen, A.T. Natarajan, Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following in vivo inhalation exposure to 1,3-butadiene, Mutat. Res. 309 (1994) 299-306.
3. D.J. Winton, M.A. Blount, B.A.J. Ponder, A clonal marker induced by mutation in mouse intestinal epithelium, Nature 333 (1988) 463-466.
4. J.A. Gossen, W.J.F. de Leeuw, C.H.T. de Leeuw, E.C. Zwarthoff, F. Berends, P.H.M. Lohman, Efficient rescue of integrated shuttle vectors from transgenic mice: a new model for studying mutations in vivo, Proc. Natl. Acad. Sci. USA 86 (1989) 7971-7975.
5. S.W. Kohler, G.S. Provost, A. Fieck, P.L. Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman, J.M. Short, Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice, Proc. Natl. Acad. Sci. USA 88 (1991) 7958-7962.
6. M.J. Dycaico, G.S. Provost, P.L. Kretz, S.L. Ranson, J.C. Moores, J.M. Short, The use of shuttle vectors for mutation analysis in transgenic mice and rats, Mutat. Res. 307 (1994) 461-478.
7. N.P. Singh, Microgel electrophoresis of DNA from individual cells. Principles and methodology, in: G.D. Pfeifer (Ed.), Technologies for Detection of DNA Damage and Mutations, Plenum, New York, 1996, pp. 3-24.
8. N.J. Gorelick, Overview of mutation assays in transgenic mice for routine testing, Environ. Mol. Mutagen. 25 (1995) 218-230.
9. M.J. Dycaico, G.R. Stuart, G.M. Tobal, J.G. de Boer, B.W. Glickman, G.S. Provost, Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1, Carcinogenesis 17 (1996) 2347-2356.
10. T. Suzuki, M. Hayashi, M. Ochiai, K. Wakabayashi, T. Ushijima, T. Sugimura, M. Nagao, T. Sofuni, Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice, Mutat. Res. 369 (1996) 45-49.
11. E.J. Mientjes, A. Luiten-Schuite, E. van der Wolf, Y. Borsboom, A. Bergmans, F. Berends, P.H.M. Lohman, R.A. Baan, J.H.M. van Delft, DNA adducts, mutant frequencies, and mutation spectra in various organs of λlacZ mice exposed to ethylating agents, Environ. Mol. Mutagen. 31 (1998) 18-31.
12. R.R. Young, B.J. Rogers, G.S. Provost, J.M. Short, D.L. Putman, Interlaboratory comparison: liver spontaneous mutant frequency from lambda/lacI transgenic mice (Big Blue) (II), Mutat. Res. 327 (1995) 67-73.
13. Collaborative Study Group for the Transgenic Mouse Mutation Assay, Organ variation in the mutagenicity of ethylnitrosourea in Muta™ Mouse: results of the collaborative study group on the transgenic mouse mutation assay by JEMS/MMS, Environ. Mol. Mutagen. 28 (1996) 363-375.
14. J. Ashby, N.J. Gorelick, M.D. Shelby, Mutation assays in male germ cells from transgenic mice: overview of study and conclusions, Mutat. Res. 388 (1997) 111-122.
15. T.R. Skopek, K.L. Kort, D.R. Marino, Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice, Environ. Mol. Mutagen. 26 (1995) 9-15.
16. V.E. Walker, N.J. Gorelick, J.L. Andrews, T.R. Craft, J.G. de Boer, B.W. Glickman, T.R. Skopek, Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice, Cancer Res. 56 (1996) 4654-4661.
17. K.S. Tao, C. Urlando, J.A. Heddle, Comparison of somatic mutation in a transgenic versus host locus, Proc. Natl. Acad. Sci. USA 90 (1993) 10681-10685.
18. P.M. Shaver-Walker, C. Urlando, K.S. Tao, X.B. Zhang, J.A. Heddle, Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea, Proc. Natl. Acad. Sci. USA 92 (1995) 11470-11474.
19. J.H.M. van Delft, A. Bergmans, R.A. Baan, Germ-cell mutagenesis in λlacZ transgenic mice treated with ethylating and methylating agents; comparison with specific-locus test, Mutat. Res. 388 (1997) 165-173.
20. a homozygous mouse congenic to C57B16/J, Mouse Genome 90 (1992) 690-692.
21. V.E. Walker, T.R. Skopek, Age-dependent relationships between exposure and phenotypic expression of hprt mutations in T-cells from mice treated with N-ethyl-N-nitrosurea, Environ. Mol. Mutagen. 21 (1993) 75, Suppl. 22.
22. - phages based on galactose sensitivity, Transgenic Res. 3 (1994) 67-69.
23. D.J. Winton, N.J. Gooderham, A.R. Boobis, D.S. Davies, B.A.J. Ponder, Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline, Cancer Res. 50 (1990) 7992-7996.
24. A.D. Tates, F.J. van Dam, H. van Mossel, H. Schoemaker, J.C.P. Thijssen, V.M. Wolding, A.N. Zwindermanand, A.T. Natarajan, Use of the clonal assay for the measurement of frequencies of NPRT mutants in T-lymphocytes from five control populations, Mutat. Res. 253 (1991) 199-213.
25. F.J. van Dam, A.T. Natarajan, A.D. Tates, Use of a T-lymphocyte clonal assay for determining hprt mutant frequencies in individual rats, Mutat. Res. 271 (1992) 231-242.
26. G.J. Carr, N.J. Gorelick, Statistical design and analysis of mutation studies in transgenic mice, Environ. Mol. Mutagen. 25 (1995) 246-255.
27. K.S. Tao, C. Urlando, J.A. Heddle, Mutagenicity of methyl methanesulfonate (MMS) in vivo at the Dlb-1 native locus and a lacI transgene, Environ. Mol. Mutagen. 22 (1993) 293-296.
28. J.G. Jansen, G.R. Mohn, H. Vrieling, C.M.M. van Teijlingen, P.H.M. Lohman, A.A. van Zeeland, Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea 1, Cancer Res. 54 (1994) 2478-2485.
29. 6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulphonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea, Cancer Res. 55 (1995) 1875-1882.
30. 6-methylguanine in bone marrow and not in the spleen, Carcinogenesis 17 (1996) 2183-2191.
31. D. Gunz, S.E. Shephard, W.K. Lutz, Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay?, Environ. Mol. Mutagen. 21 (1993) 209-211.
32. T. Sofuni, T. Suzuki, M. Hayashi, Initial consideration for use of transgenic assays in regulatory submission, Environ. Mol. Mutagen. 28 (1996) 443-446.