Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 867, Issue 1, 2008, Pages 84-89

  Liu, Xing ^a   Wang, Yang ^a   Vardeman, Dana ^a   Cao, Zhisong ^a   Giovanella, Beppino ^a  

^a Stehlin Found for Cancer Research   (United States)

Author keywords

Camptothecin; Chromatography; CZ48; HPLC; Quantification

Indexed keywords

FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; RATS;

FLUORESCENCE DETECTORS; METABOLITE CAMPTOTHECIN; MOUSE PLASMA;

TUMORS;

ANTINEOPLASTIC AGENT; C20 PROPIONATE ESTER OF CAMPTOTHECIN; CAMPTOTHECIN; CZ 48;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CALIBRATION; EXCITATION; FLUORESCENCE ANALYSIS; FREEZE THAWING; INCUBATION TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; STANDARD; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; CALIBRATION; CAMPTOTHECIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

MUS;

EID: 42749083699     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.03.013     Document Type: Article

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