Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population

Psychiatry Research

Volumn 159, Issue 1-2, 2008, Pages 245-249

  Ma, Jie ^a,b   Fan, Jin Bo ^a,b   Bian, Li ^b   Zhang, Chang Shun ^a   Li, Xing Wang ^a   Gu, Niu Fan ^c   Feng, Guo Yin ^c   St Clair, David ^d   He, Lin ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

^c SHANGHAI MENTAL HEALTH CENTER   (China)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Association; CHRFAM7A; CHRNA7; Schizophrenia; TDT

Indexed keywords

ADULT; ARTICLE; CHINESE; CHROMOSOME 15Q; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DISEASE TRANSMISSION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGENY; SCHIZOPHRENIA;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 15; DINUCLEOTIDE REPEATS; FAMILY; FEMALE; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, GENETIC; SCHIZOPHRENIA;

EID: 42749083185     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2007.07.002     Document Type: Article

References (34)

1. Curtis L., Blouin J.L., Radhakrishna U., Gehrig C., Lasseter V.K., Wolyniec P., Nestadt G., Dombroski B., Kazazian H.H., Pulver A.E., Housman D., Bertrand D., and Antonarakis S.E. No evidence for linkage between schizophrenia and markers at chromosome 15q13-14. American Journal of Medical Genetics 88 (1999) 109-112
2. De Luca V., Wang H., Squassina A., Wong G.W., Yeomans J., and Kennedy J.L. Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. Neuropsychobiology 50 (2004) 124-127
3. Fan J.B., Tang J.X., Gu N.F., Feng G.Y., Zou F.G., Xing Y.L., Shi J.G., Zhao S.M., Zhu S.M., Ji L.P., Sun W.W., Zheng Y.L., Liu W.Q., Breen G.., Clair D.S., and He L. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Molecular Psychiatry 7 (2002) 100-103
4. Fan J.B., Ma J., Li X.W., Zhang C.S., Sun W.W., He G., Gu N.F., Feng G.Y., Clair D.S., and He L. Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia. Schizophrenia Research 84 (2006) 222-227
5. Flomen R.H., Collier D.A., Osborne S., Munro J., Breen G., Clair D.S., and Makoff A.J. Association study of CHRFAM7A copy number and 2bp deletion polymorphisms with schizophrenia and bipolar affective disorder. American Journal of Medical Genetics 114 (2006) 571-575
6. Freedman R., and Leonard S. Genetic linkage to schizophrenia at chromosome 15q14. American Journal of Medical Genetics 105 (2001) 655-657
7. Freedman R., Coon H., Myles-Worsley M., Orr-Urtreger A., Olincy A., Davis A., Polymeropoulos M., Holik J., Hopkins J., Hoff M., Rosenthal J., Waldo M.C., Reimherr F., Wender P., Yaw J., Young D.A., Breese C.R., Adams C., Patterson D., Adler L.E., Kruglyak L., Leonard S., and Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 587-592
8. Freedman R., Leonard S., Gault J.M., Hopkins J., Cloninger C.R., Kaufmann C.A., Tsuang M.T., Faraone S.V., Malaspina D., Svrakic D.M., Sanders A., and Gejman D. Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha 7-nicotinic acetylcholine receptor subunit gene (CHRNA7). American Journal of Medical Genetics 105 (2001) 20-22
9. Freedman R., Leonard S., Olincy A., Kaufmann C.A., Malaspina D., Cloninger C.R., Svrakic D., Faraone S.V., and Tsuang M.T. Evidence for the multigenic inheritance of schizophrenia. American Journal of Medical Genetics 105 (2001) 794-800
10. Freedman R., Leonard S., Waldo M., Gault J., Olincy A., and Adler L.E. Characterization of allelic variants at chromosome 15q14 in schizophrenia. Genes, Brain, and Behavior 5 (2006) 14-22
11. Gault J., Robinson M., Berger R., Drebing C., Logel J., Hopkins J., Moore T., Jacobs S., Meriwether J., Choi M.J., Kim E.J., Walton K., Buiting K., Davis A., Breese C., Freedman R., and Leonard S. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics 52 (1998) 173-185
12. Gault J., Hopkins J., Berger R., Drebing C., Logel J., Walton C., Short M., Vianzon R., Olincy A., Ross R.G., Adler L.E., Freedman R., and Leonard S. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. American Journal of Medical Genetics 12 (2003) 339-349
13. Gejman P.V., Sanders A.R., Badner J.A., Cao Q., and Zhang J. Linkage analysis of schizophrenia to chromosome 15. American Journal of Medical Genetics 105 (2001) 789-793
14. Harrison P.J., and Owen M.J. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 36 (2003) 1417-1419
15. He L., Li T., Melville C., Liu S., Feng G.Y., Gu N.F., Fox H., Shaw D., Breen G., Liu X., Sham P., Brown J., Collier D., and Clair D.S. 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. American Journal of Medical Genetics 88 (1999) 95-98
16. Kirov G., O'Donovan M.C., and Owen M.J. Finding schizophrenia genes. Journal of Clinical Investigation 115 (2005) 1440-1448
17. Lai I.C., Hong C.J., and Tsai S.J. Association study of a nicotinic receptor variant with schizophrenic disorders. Neuropsychobiology 43 (2001) 15-18
18. Leonard S., and Freedman R. Genetics of chromosome 15q13-q14 in schizophrenia. Biological Psychiatry 60 (2006) 115-122
19. Leonard S., Gault J., Moore T., Hopkins J., Robinson M., Olincy A., Adler L.E., Cloninger R., Kaufmann C.A., Tsuang M.T., Faraone S.V., Malaspina D., Svrakic D.M., and Freedman R. Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected subpairs from the NIMH Genetics Initiative. American Journal of Medical Genetics 81 (1998) 308-312
20. Leonard S., Gault J., Hopkins J., Logel J., Vianzon R., Short M., Drebing C., Berger R., Venn D., Sirota P., Zerbe G., Olincy A., Ross R.G., Adler L.E., and Freedman R. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Archives of General Psychiatry 59 (2002) 1085-1096
21. Li C.H., Liao H.M., and Chen C.H. Identification of molecular variants at the promoter region of the human α7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia. Neuroscience Letters 372 (2004) 1-5
22. Liu C.M., Hwu H.G., Lin M.W., Ou-Yang W.C., Lee S.F.C., Fann C.S.J., Wong S.H., and Hsieh S.H. Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families. American Journal of Medical Genetics 105 (2001) 658-661
23. Neves-Pereira M., Bassett A.S., Honer W.G., Lang D., King N.A., and Kennedy J.L. No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families. American Journal of Medical Genetics 81 (1998) 361-363
24. Raymond M., and Rousset F. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. Journal of Heredity 86 (1995) 248-249
25. Riley B.P., Makoff A., Mogudi-Carter M., Jenkins T., Williamson R., Collier D., and Murray R. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families. American Journal of Medical Genetics 96 (2000) 196-201
26. Riley B.P., Williamson M., Collier D., Wilkie H., and Makoff A. A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. Genomics 79 (2002) 197-209
27. Sham P.C., and Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Annals of Human Genetics 59 (1995) 97-105
28. Sham P.C., and Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Annals of Human Genetics 59 (1995) 323-336
29. Spielman R.S., McGinnis R.E., and Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics 52 (1993) 506-516
30. Stassen H.H., Bridler R., Hagele S., Hergersberg M., Mehmann B., Schinzel A., Weisbrod M., and Scharfetter C. Schizophrenia and smoking: evidence for a common neurobiological basis?. American Journal of Medical Genetics 96 (2000) 173-177
31. Stober G., Saar K., Ruschendorf F., Meyer J., Nurnberg G., Jatzke S., Franzek E., Reis A., Lesch K.P., Wienker T.F., and Beckmann H. Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15. American Journal of Human Genetics 67 (2000) 1201-1207
32. Tsuang D.W., Skol A.D., Faraone S.V., Bingham S., Young K.A., Prabhudesai S., Haverstock S.I., Mena F., Menon A.S., Bisset D., Pepple J., Sauter F., Baldwin C., Weiss D., Collins J., Boehnke M., Schellenberg G.D., and Tsuang M.T. Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative study sample. American Journal of Medical Genetics 105 (2001) 662-668
33. Xu J., Pato M.T., Torre C.D., Medeiros H., Carvalho C., Basile V.S., Bauer A., Dourado A., Valente J., Soares M.J., Macedo A.A., Coelho I., Ferreira C.P., Azevedo M.H., Macciardi H., Kennedy J.L., and Pato C.N. Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families. American Journal of Medical Genetics 105 (2001) 669-674
34. Zheng Y.L., Li H.F., Qin W., Chen W.Y., Duan Y., Xiao Y., Li C., Zhang J., Li X.W., Feng G.Y., and He L. Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochemical and Biophysical Research Communications 328 (2005) 809-815