Effect of polymorphism in the porcine cytochrome b5 (CYB5A) gene on androstenone and skatole concentrations and sexual development in Swedish pig populations

Animal

Volumn 2, Issue 2, 2008, Pages 190-196

  Zamaratskaia, G ^a   Lou, Y ^b   Peacock, J ^b   Rydhmer, L ^a   Andersson, H K ^a   Juneja, R K ^a   Chen, G ^a   Lundstrom K ^a   Squires, E J ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Androstenone; Cytochrome b5 gene; Pigs; Sexual development; Skatole

Indexed keywords

ANIMALIA; SUIDAE; SUS;

EID: 42649102961     PISSN: 17517311     EISSN: 1751732X     Source Type: Journal    
DOI: 10.1017/S1751731107001103     Document Type: Article

References (38)

1. Akhtar MK, Kelly SL and Kaderbhai MA 2005. Cytochrome b5 modulation of 17α- hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. Journal of Endocrinology 187, 267-274.
2. Andersson HK, Andersson K, Zamaratskaia G, Rydhmer L, Chen G and Lundström K 2005. Effect of single-sex or mixed raising and live weight on performance, technological meat quality and sexual maturity in entire male and female pigs fed raw potato starch. Acta Agriculturae Scandinavica 55, 80-90.
3. Babol J, Zamaratskaia G, Juneja K and Lundström K 2004. The effect of age on distribution of skatole and indole levels in entire male pigs in four breeds: Yorkshire, Landrace, Hampshire and Duroc. Meat Science 67, 351-358.
4. Bonneau M 1987. Effects of age and live weight on fat 5 alpha-androstenone levels in young boars fed two planes of nutrition. Reproduction, Nutrition, Development 27, 413-422.
5. Booth WD and White CA 1988. The isolation, purification and some properties of pheromaxein, the pheromonal steroid-binding protein, in porcine submaxillary glands and saliva. Journal of Endocrinology 118, 47-57.
6. Chen G, Zamaratskaia G, Andersson HK and Lundström K 2007a. Effect of dietary supplement of raw potato starch and live weight on the levels of skatole, indole and androstenone measured by different methods. Food Chemistry 101, 439-448.
7. Chen G, Cue RA, Lundstrom K, Wood JD and Doran O 2007b. Regulation of cytochrome P450 2A6 protein expression by skatole, indole and testicular steroids in primary cultured pig hepatocytes. Drug Metabolism and Disposition, in press.
8. Claus R, Lösel D, Lacorn M, Mentschel J and Schenkel H 2003. Effects of butyrate on apoptosis in the pig colon and its consequences for skatole formation and tissue accumulation. Journal of Animal Science 81, 239-248.
9. Davis SM and Squires EJ 1999. Association of cytochrome b5 with 16-androstene steroid synthesis in the testis and accumulation in the fat of male pigs. Journal of Animal Science 77, 1230-1235.
10. Diaz GJ and Squires EJ 2000. Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes. Toxicological Sciences 55, 284-292.
11. Doran E, Whittington FW, Wood JD and McGivan JD 2002. Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chemico-Biological Interactions 140, 81-92.
12. Gower DB 1972. 16-Unsaturated C 19 steroids. A review of their chemistry, biochemistry and possible physiological role. Journal of Steroid Biochemistry 3, 45-103.
13. Hansen LL, Larsen AE, Jensen BB, Hansen-Møller J and Barton-Gade P 1994. Influence of stocking rate and faeces deposition in the pen at different temperatures on skatole concentration (boar taint) in subcutaneous fat. Animal Production 59, 99-110.
14. Hansen LL, Lundström K, Laue A, Jensen MT, Agergaard N and Bæk CÆ 1997. Skatole and androstenone patterns during the growth period from 90 to 120 kg live weight in pigs with high or low skatole levels in back fat at slaughter. In Boar taint in entire male pigs (ed. M Bonneau, K Lundström and B Malmfors), EAAP publication no. 92, pp. 100-103. Wageningen Pers, The Netherlands.
15. Lin Z, Lou Y, Peacock J and Squires EJ 2004a. Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: a single mutation SULT1A1 causes a significant decrease in sulfation activity. Mammalian Genome 5, 218-226.
16. Lin Z, Lou Y, Peacock J and Squires EJ 2004b. Molecular cloning, expression and functional characterization of the cytochrome P450 2A6 gene in pig liver. Animal Genetics 35, 314-316.
17. Lin Z, Lou Y, Peacock J and Squires EJ 2005. A novel polymorphism in the 5′ untranslated region of the porcine cytochrome b5 (CYB5) gene is associated with decreased fat androstenone level. Mammalian Genome 16, 367-373.
18. Lin Z, Lou Y and Squires EJ 2006. Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels. Journal of Steroid Biochemistry and Molecular Biology 99, 231-237.
19. Lundström K, Malmfors B, Hansson I, Edqvist L-E and Gahne B 1978. 5α-Androstenone and testosterone in boars. Swedish Journal of Agricultural Research 8, 171-178.
20. Meadus WJ, Mason JI and Squires EJ 1993. Cytochrome P450c17 from porcine and bovine adrenal catalyses the formation of 5,16 androstadien-3b-ol from pregnenolone in the presence of cytochrome b5. Journal of Steroid Biochemistry and Molecular Biology 46, 565-572.
21. Mortensen AB and Sørensen SE 1984. Relationship between boar taint and skatole determination with a new analysis method. Proceedings of 30th European Meeting of Meat Research Workers, Bristol, UK, pp. 394-396.
22. Pandey AV and Miller WL 2005. Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. The Journal of Biological Chemistry 280, 13265-13271.
23. Peacock J, Lou Y, Lundström K and Squires EJ 2007. The effect of a -8G > T polymorphism on the expression of cytochrome b5 and boar taint in pigs. Animal Genetics, in press.
24. Pedersen B 1998. Heritability of skatole in back fat. In Skatole and boar taint (ed. WK Jensen), pp. 129-136. Roskilde, Denmark.
25. Quintanilla R, Demeure O, Bidanel JP, Milan D, Iannuccelli N, Amigues Y, Gruand J, Renard C, Chevalet C and Bonneau M 2003. Detection of quantitative trait loci for fat androstenone levels in pigs. Journal of Animal Science 81, 385-394.
26. Sellier P 1998. Genetics of meat and carcass traits. In The genetics of the pig (ed. MF Rothschild and A Ruvinsky), pp. 463-510. CAB International, Wallingford, Oxon, UK.
27. Sinclair PA, Squires EA, Raeside JI, Britt JH and Hedgpeth VG 2001. The effect of early postnatal treatment with a gonadotropin-releasing hormone agonist on the developmental profiles of testicular steroid hormones in the intact male pig. Journal of Animal Science 79, 1003-1010.
28. Skinner TM, Doran E, McGivan JD, Haley CS and Archibald AL 2005. Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig. Animal Genetics 36, 417-422.
29. Skinner TM, Anderson JA, Haley CS and Archibald AL 2006. Assessment of SULT1A1, CYP2A6 and CYP2C18 as candidate genes for elevated backfat skatole levels in commercial and experimental pig populations. Animal Genetics 37, 521-522.
30. Statistical Analysis Systems Institute 2004. Version 9.1. SAS Institute, Cary, NC, USA.
31. Tambyrajah WS, Doran E, Wood JD and McGivan JD 2004. The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Archives of Biochemistry and Biophysics 431, 252-260.
32. Walstra P, Claudi-Magnussen C, Chevillon P, Von Seth G, Diestre A, Matthews KR, Homer DB and Bonneau M 1999. An international study on the importance of androstenone and skatole for boar taint: levels of androstenone and skatole by country and season. Livestock Production Science 62, 15-28.
33. Xue J, Dial GD, Holton EE, Vickers Z, Squires EJ, Lou Y, Gotbout D and Morel N 1996. Breed differences in boar taint: relationship between tissue levels of boar taint compounds and sensory analysis of taint. Journal of Animal Science 74, 2170-2177.
34. Zamaratskaia G, Babol J, Andersson H and Lundström K 2004a. Plasma skatole and androstenone levels in entire male pigs and relationship between boar taint compounds, sex steroids and thyroxine at various ages. Livestock Production Science 87, 91-98.
35. Zamaratskaia G, Babol J, Madej A, Squires EJ and Lundström K 2004b. Age-related variation of plasma concentrations of skatole, androstenone, testosterone, oestradiol-17 beta, oestrone sulphate, dehydroepiandrosterone sulphate, triiodothyronine and IGF-1 in six entire male pigs. Reproduction in Domestic Animals 39, 168-172.
36. Zamaratskaia G, Squires EJ, Babol J, Andersson HK, Andersson K and Lundström K 2005a. Relationship between the activities of cytochromes P4502E1 and P4502A6 and skatole content in fat in entire male pigs fed with and without raw potato starch. Livestock Production Science 95, 83-88.
37. Zamaratskaia G, Babol J, Andersson HK, Andersson K and Lundström K 2005b. Effect of live weight and dietary supplement of raw potato starch on the levels of skatole, androstenone, testosterone and oestrone sulphate in entire male pigs. Livestock Production Science 93, 235-243.
38. Zamaratskaia G, Gilmore WJ, Lundström K and Squires EJ 2007. Effect of testicular steroids on catalytic activities of cytochrome P450 enzymes in porcine liver microsomes. Food and Chemical Toxicology 45, 676-681.