Transactivation of a growth hormone (GH) promoter-luciferase construct in canine mammary cells

Domestic Animal Endocrinology

Volumn 34, Issue 4, 2008, Pages 403-410

  Timmermans Sprang, Elpetra P M ^a   Rao, Nagesha A S ^a   Mol, Jan A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

GH; Mammary tumor cells; Progesterone; Reporter construct

Indexed keywords

CYCLIC AMP; EPIDERMAL GROWTH FACTOR; GROWTH HORMONE; LIOTHYRONINE; LUCIFERASE; PROGESTERONE; RETINOIC ACID; VITAMIN D;

ANIMAL; ARTICLE; CELL CULTURE; DOG; DRUG EFFECT; FEMALE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; PROMOTER REGION; REPORTER GENE; TRANSACTIVATION; UDDER; VALIDATION STUDY;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; DOGS; EPIDERMAL GROWTH FACTOR; FEMALE; GENES, REPORTER; GROWTH HORMONE; LUCIFERASES; MAMMARY GLANDS, ANIMAL; PROGESTERONE; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRETINOIN; TRIIODOTHYRONINE; VITAMIN D;

CANIS FAMILIARIS;

EID: 42649090817     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2007.11.001     Document Type: Article

References (42)

1. Perry J.K., Emerald B.S., Mertani H.C., and Lobie P.E. The oncogenic potential of growth hormone. Growth Horm IGF Res 16 (2006) 277-289
2. Jenkins P.J. Acromegaly and cancer. Horm Res 62 Suppl 1 (2004) 108-115
3. Wagner K., Hemminki K., Israelsson E., Grzybowska E., Klaes R., Chen B., et al. Association of polymorphisms and haplotypes in the human growth hormone 1 (GH1) gene with breast cancer. Endocr Relat Cancer 12 (2005) 917-928
4. Schernhammer E.S., Holly J.M., Hunter D.J., Pollak M.N., and Hankinson S.E. Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in the nurses health study II. Endocr Relat Cancer 13 (2006) 583-592
5. Mol J.A., van Garderen E., Rutteman G.R., and Rijnberk A. New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. J Steroid Biochem Mol Biol 57 (1996) 67-71
6. Mol J.A., van Garderen E., Selman P.J., Wolfswinkel J., Rijnberk A., and Rutteman G.R. Growth hormone mRNA in mammary gland tumors of dogs and cats. J Clin Invest 95 (1995) 2028-2034
7. Selman P.J., Mol J.A., Rutteman G.R., van Garderen E., and Rijnberk A. Progestin-induced growth hormone excess in the dog originates in the mammary gland. Endocrinology 134 (1994) 287-292
8. Yakar S., Leroith D., and Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models. Cytokine Growth Factor Rev 16 (2005) 407-420
9. Waters M.J., and Conway-Campbell B.L. The oncogenic potential of autocrine human growth hormone in breast cancer. Proc Natl Acad Sci USA 101 (2004) 14992-14993
10. Theill L.E., and Karin M. Transcriptional control of GH expression and anterior pituitary development. Endocr Rev 14 (1993) 670-689
11. Brent G.A., Harney J.W., Moore D.D., and Larsen P.R. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3′,5′-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol 2 (1988) 792-798
12. Lengyel A.M. Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin. Braz J Med Biol Res 39 (2006) 1003-1011
13. Cooke N.E., and Liebhaber S.A. Molecular biology of the growth hormone-prolactin gene system. Vitam Horm 50 (1995) 385-459
14. Tuggle C.K., and Trenkle A. Control of growth hormone synthesis. Domest Anim Endocrinol 13 (1996) 1-33
15. Palomino T., Barettino D., and Aranda A. Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors. J Biol Chem 273 (1998) 27541-27547
16. Palomino T., Sanchez-Pacheco A., Pena P., and Aranda A. A direct protein-protein interaction is involved in the cooperation between thyroid hormone and retinoic acid receptors and the transcription factor GHF-1. Faseb J 12 (1998) 1201-1209
17. Garcia-Villalba P., Jimenez-Lara A.M., and Aranda A. Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid. Mol Cell Biol 16 (1996) 318-327
18. Lantinga-van Leeuwen I.S., Timmermans-Sprang E.A., and Mol J.A. Cloning and characterization of the 5′-flanking region of the canine growth hormone gene. Mol Cell Endocrinol 197 (2002) 133-141
19. Hellmén E., Moller M., Blankenstein M.A., Andersson L., and Westermark B. Expression of different phenotypes in cell lines from canine mammary spindle-cell tumours and osteosarcomas indicating a pluripotent mammary stem cell origin. Breast Cancer Res Treat 61 (2000) 197-210
20. Van Leeuwen I.S., Hellmén E., Cornelisse C.J., Van den Burgh B., and Rutteman G.R. p53 mutations in mammary tumor cell lines and corresponding tumor tissues in the dog. Anticancer Res 16 (1996) 3737-3744
21. Hellmén E. Characterization of four in vitro established canine mammary carcinoma and one atypical benign mixed tumor cell lines. In Vitro Cell Dev Biol 28A (1992) 309-319
22. Pfaffl M.W., Horgan G.W., and Dempfle L. Relative expression software tool (rest) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl Acids Res 30 (2002) e36
23. Cohen L.E., Hashimoto Y., Zanger K., Wondisford F., and Radovick S. CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest 104 (1999) 1123-1130
24. Tansey W.P., Schaufele F., Heslewood M., Handford C., Reudelhuber T.L., and Catanzaro D.F. Distance-dependent interactions between basal, cyclic AMP, and thyroid hormone response elements in the rat growth hormone promoter. J Biol Chem 268 (1993) 14906-14911
25. Schanke J.T., Durning M., Johnson K.J., Bennett L.K., and Golos T.G. Sp1/Sp3-binding sites and adjacent elements contribute to basal and cyclic adenosine 3′,5′-monophosphate-stimulated transcriptional activation of the rhesus growth hormone-variant gene in trophoblasts. Mol Endocrinol 12 (1998) 405-417
26. Seoane S., Alonso M., Segura C., and Perez-Fernandez R. Localization of a negative vitamin D response sequence in the human growth hormone gene. Biochem Biophys Res Commun 292 (2002) 250-255
27. Seoane S., and Perez-Fernandez R. The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor. Mol Endocrinol 20 (2006) 735-748
28. Ansell P.J., Zhou Y., Schjeide B.M., Kerner A., Zhao J., Zhang X., et al. Regulation of growth hormone expression by delta-like protein 1 (DLK1). Mol Cell Endocrinol 271 (2007) 55-63
29. Andersen B., and Rosenfeld M.G. Pou domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev 22 (2001) 2-35
30. Welsh J., Wietzke J.A., Zinser G.M., Smyczek S., Romu S., Tribble E., et al. Impact of the vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol 83 (2002) 85-92
31. Pendas-Franco N., Gonzalez-Sancho J.M., Suarez Y., Aguilera O., Steinmeyer A., Gamallo C., et al. Vitamin D regulates the phenotype of human breast cancer cells. Differentiation 75 (2007) 193-207
32. Seoane S., Ben I., Centeno V., and Perez-Fernandez R. Cellular expression levels of the vitamin D receptor are critical to its transcriptional regulation by the pituitary transcription factor Pit-1. Mol Endocrinol 21 (2007) 1513-1525
33. Iwasaki Y., Morishita M., Asai M., Onishi A., Yoshida M., Oiso Y., et al. Effects of hormones targeting nuclear receptors on transcriptional regulation of the growth hormone gene in the Mtt/s rat somatotrope cell line. Neuroendocrinology 79 (2004) 229-236
34. Lantinga-van Leeuwen I.S., van Garderen E., Rutteman G.R., and Mol J.A. Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland. J Steroid Biochem Mol Biol 75 (2000) 219
35. Schoonen W.G., Dijkema R., de Ries R.J., Wagenaars J.L., Joosten J.W., de Gooyer M.E., et al. Human progesterone receptor A and B isoforms in CHO cells. II. Comparison of binding, transactivation and ED50 values of several synthetic (anti)progestagens in vitro in CHO and MCF-7 cells and in vivo in rabbits and rats. J Steroid Biochem Mol Biol 64 (1998) 157-170
36. Prefontaine G.G., Walther R., Giffin W., Lemieux M.E., Pope L., and Hache R.J. Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter. J Biol Chem 274 (1999) 26713-26719
37. Blaustein J.D. Minireview: neuronal steroid hormone receptors: they're not just for hormones anymore. Endocrinology 145 (2004) 1075-1081
38. Cenni B., and Picard D. Ligand-independent activation of steroid receptors: new roles for old players. Trends Endocrinol Metab 10 (1999) 41-46
39. Daniel A.R., Qiu M., Faivre E.J., Ostrander J.H., Skildum A., and Lange C.A. Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth. Steroids 72 (2007) 188-201
40. Selman P.J., Mol J.A., Rutteman G.R., and Rijnberk A. Progestin treatment in the dog. I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis. Eur J Endocrinol 131 (1994) 413-421
41. Bhatti S.F., Duchateau L., Okkens A.C., Van Ham L.M., Mol J.A., and Kooistra H.S. Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology 66 (2006) 797-803
42. Booth B.W., and Smith G.H. Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands. Breast Cancer Res 8 (2006) R49