Ependymal tumors with sarcomatous change ("ependymosarcoma"): A clinicopathologic and molecular cytogenetic study

American Journal of Surgical Pathology

Volumn 32, Issue 5, 2008, Pages 699-709

  Rodriguez, Fausto J ^a   Scheithauer, Bernd W ^a   Perry, Arie ^b   Oliveira, Andre M ^a   Jenkins, Robert B ^a   Oviedo, Angelica ^c   Mork, Sverre J ^d   Palmer, Cheryl A ^e   Burger, Peter C ^f  

^a MAYO CLINIC   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KAISER PERMANENTE   (United States)

^d UNIVERSITY OF BERGEN   (Norway)

^e University of Alabama at Birmingham   (United States)

^f DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Ependymoma; Ependymosarcoma; FISH; Glioma; Gliosarcoma; Immunohistochemistry; Sarcoma; Subependymoma

Indexed keywords

CARBOPLATIN; CISPLATIN; ETOPOSIDE; IFOSFAMIDE; TEMOZOLOMIDE; VINCRISTINE;

ADULT; AGED; ARTICLE; CANCER GRADING; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHROMOSOME 22Q; CHROMOSOME DELETION; CLINICAL ARTICLE; CLINICAL FEATURE; COMBINATION CHEMOTHERAPY; CYTOGENETICS; EPENDYMOMA; EPENDYMOSARCOMA; FEMALE; FIBROSARCOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GAMMA KNIFE RADIOSURGERY; GENE; GLIOSARCOMA; HISTOPATHOLOGY; HUMAN; MALE; NF2 GENE; NUCLEAR MAGNETIC RESONANCE IMAGING; SARCOMA; SPINDLE CELL SARCOMA;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; COMBINED MODALITY THERAPY; DNA, NEOPLASM; EPENDYMOMA; FEMALE; FIBROSARCOMA; GENE AMPLIFICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; SURVIVAL RATE;

EID: 42649088067     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318158234e     Document Type: Article

References (42)

1. Actor B, Cobbers JM, Buschges R, et al. Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes Chromosomes Cancer. 2002;34:416-427.
2. Agozzino L, Pittore L, Lamendola MG et al. Sarcoma arising in a cerebral oligodendroglioma. Case report. Pathologica. 1983;75:501-508.
3. Banerjee AK, Sharma BS, Kak VK, et al. Gliosarcoma with cartilage formation. Cancer. 1989;63:518-523.
4. Barnard RO, Bradford R, Scott T, et al. Gliomyosarcoma. Report of a case of rhabdomyosarcoma arising in a malignant glioma. Acta Neuropathol. 1986;69:23-27.
5. Batsakis JG, Suarez P. Sarcomatoid carcinomas of the upper aerodigestive tracts. Adv Anat Pathol. 2000;7:282-293.
6. Behling E, Birbe R, Veznadaroglu E, et al. Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity. Hum Pathol. 2004;35:512-516.
7. Biernat W, Aguzzi A, Sure U, et al. Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells. J Neuropathol Exp Neurol. 1995;54:651-656.
8. Boerman RH, Anderl K, Herath J, et al. The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol. 1996;55:973-981.
9. Borota OC, Scheie D, Bjerkhagen B, et al. Gliosarcoma with liposarcomatous component, bone infiltration and extracranial growth. Clin Neuropathol. 2006;25:200-203.
10. Burger PC, Scheithauer BW, Vogel FS. Surgical Pathology of the Nervous System and Its Coverings. 4th ed. Philadelphia: Churchill Livingstone; 2002.
11. Carter MR, Hornick JL, Lester S, et al. Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 2006;30:300-309.
12. Cheville JC, Lohse CM, Zincke H, et al. Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. Am J Surg Pathol. 2004;28:435-441.
13. Dyer S, Prebble E, Davison V, et al. Genomic imbalances in pediatric intracranial ependymomas define clinically relevant groups. Am J Pathol. 2002;161:2133-2141.
14. Feigin I, Allen LB, Lipkin L, et al. The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer. 1958;11:264-277.
15. Feigin I, Ransohoff J, Lieberman A. Sarcoma arising in oligodendroglioma of the brain. J Neuropathol Exp Neurol. 1976;35:679-684.
16. Gessi M, Marani C, Geddes J, et al. Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications. Acta Neuropathol. 2005;109:231-234.
17. Haddad SF, Moore SA, Schelper RL, et al. Smooth muscle can comprise the sarcomatous component of gliosarcomas. J Neuropathol Exp Neurol. 1992;51:493-498.
18. Hansel DE, Epstein JI. Sarcomatoid carcinoma of the prostate: a study of 42 cases. Am J Surg Pathol. 2006;30:1316-1321.
19. Hayashi K, Ohara N, Jeon HJ, et al. Gliosarcoma with features of chondroblastic osteosarcoma. Cancer. 1993;72:850-855.
20. Higashino T, Inamura T, Kawashima M, et al. A lateral ventricular gliosarcoma arising in an ependymoma. Clin Neuropathol. 2001;20: 219-223.
21. Kawano N, Ohba Y, Nagashima K. Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study. Acta Neuropathol (Berl). 2000;99:214-218.
22. Kepes JJ, Bastian FO, Weber ED. Gliosarcoma developing from an irradiated ependymoma. Acta Neuropathol. 1996;92:515-519.
23. Kleihues P, Cavenee WK. Pathology and Genetics of Tumours of the Nervous System. World Health Organization Classification of Tumours. Lyon, France: IARC press; 2000.
24. Louis DN, Hedley-Whyte ET, Martuza RL. Sarcomatous proliferation of the vasculature in a subependymoma. Acta Neuropathol (Berl). 1989;78:332-335.
25. Louis DN, Hedley-Whyte ET, Martuza RL. Sarcomatous proliferation of the vasculature in a subependymoma: a follow-up study of sarcomatous dedifferentiation. Acta Neuropathol (Berl). 1990;80: 573-574.
26. Louis DN, Ohgaki H, Wiestler OD, et al. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC press; 2007.
27. Louvet-Vallee S. ERM proteins: from cellular architecture to cell signaling. Biol Cell. 2000;92:305-316.
28. Mridha AR, Sharma MC, Sarkar C, et al. Anaplastic ependymoma with cartilaginous and osseous metaplasia: report of a rare case and review of literature. J Neurooncol. 2007;82:75-80.
29. Pasquier B, Couderc P, Pasquier D, et al. Sarcoma arising in oligodendroglioma of the brain: a case with intramedullary and subarachnoid spinal metastases. Cancer. 1978;42:2753-2758.
30. Paulus W, Bayas A, Ott G, et al. Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol (Berl). 1994;88:420-425.
31. Rajaram V, Gutmann DH, Prasad SK, et al. Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Mod Pathol. 2005;18:991-997.
32. Reis RM, Konu-Lebleblicioglu D, Lopes JM, et al. Genetic profile of gliosarcomas. Am J Pathol. 2000;156:425-432.
33. Rodriguez FJ, Scheithauer BW, Jenkins R, et al. Gliosarcoma arising in oligodendroglial tumors ("oligosarcoma"): a clinicopathologic study. Am J Surg Pathol. 2007;31:351-362.
34. Rodriguez FJ, Scheithauer BW, Robbins PD, et al. Ependymomas with neuronal differentiation: a morphologic and immunohistochemical spectrum. Acta Neuropathol (Berl). 2007;113:313-324.
35. Rosenblum MK, Erlandson RA, Aleksic SN, et al. Melanotic ependymoma and subependymoma. Am J Surg Pathol. 1990;14:729-736.
36. Rossi G, Cavazza A, Sturm N, et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol. 2003;27:311-324.
37. Ruchoux MM, Kepes JJ, Dhellemmes P, et al. Lipomatous differentiation in ependymomas: a report of three cases and comparison with similar changes reported in other central nervous system neoplasms of neuroectodermal origin. Am J Surg Pathol. 1998;22:338-346.
38. Suzuki H, Fujioka Y, Nagashima K. Cyclin D1 gene amplification and p16 gene deletion in patients with esophageal carcinosarcoma. Diagn Mol Pathol. 1998;7:253-259.
39. Suzuki SO, Iwaki T. Amplification and overexpression of mdm2 gene in ependymomas. Mod Pathol. 2000;13:548-553.
40. Suzuki H, Yamashiro K, Yoshida C, et al. Carcinosarcoma of the tongue with cyclin D1 gene amplification. Arch Pathol Lab Med. 2001;125:433-436.
41. Tomlinson FH, Scheithauer BW, Kelly PJ, et al. Subependymoma with rhabdomyosarcomatous differentiation: report of a case and literature review. Neurosurgery. 1991;28:761-768.
42. Vlodavsky E, Konstantinesku M, Soustiel JF. Gliosarcoma with liposarcomatous differentiation: the new member of the lipid-containing brain tumors family. Arch Pathol Lab Med. 2006;130: 381-384.