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Volumn 13, Issue 5, 2000, Pages 548-553

Amplification and overexpression of mdm2 gene in ependymomas

Author keywords

Ependymoma; Gene amplification; Immunohistochemistry; Mdm2; Oncogene; P53

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHROMOSOME 12Q; CHROMOSOME ABERRATION; CLINICAL ARTICLE; DNA DETERMINATION; EPENDYMOMA; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION; TUMOR LOCALIZATION;

EID: 0034042177     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880095     Document Type: Article
Times cited : (37)

References (45)
  • 1
    • 0030999539 scopus 로고    scopus 로고
    • The molecular biology of ependymomas
    • Hamilton RL, Pollack IF. The molecular biology of ependymomas. Brain Pathol 1997;7:807-22.
    • (1997) Brain Pathol , vol.7 , pp. 807-822
    • Hamilton, R.L.1    Pollack, I.F.2
  • 3
    • 0031888205 scopus 로고    scopus 로고
    • Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: Reappraisal by yeast functional assay
    • Nozaki M, Tada M, Matsumoto R, Sawamura Y, Abe H, Iggo RD. Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay. Acta Neuropathol 1998;95:291-6.
    • (1998) Acta Neuropathol , vol.95 , pp. 291-296
    • Nozaki, M.1    Tada, M.2    Matsumoto, R.3    Sawamura, Y.4    Abe, H.5    Iggo, R.D.6
  • 6
    • 0029162566 scopus 로고
    • Anaplastic ependymomas: Clinical features and tumour suppressor gene p53 analysis
    • Wien
    • Tominaga T, Kayama T, Kumabe T, Sonoda Y, Yoshimoto T. Anaplastic ependymomas: clinical features and tumour suppressor gene p53 analysis. Acta Neurochir (Wien) 1995;135: 163-70.
    • (1995) Acta Neurochir , vol.135 , pp. 163-170
    • Tominaga, T.1    Kayama, T.2    Kumabe, T.3    Sonoda, Y.4    Yoshimoto, T.5
  • 8
    • 0023339504 scopus 로고
    • Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
    • Cahilly SL, Yang FT, Francke U, George DL. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat Cell Mol Genet 1987;13:235-44.
    • (1987) Somat Cell Mol Genet , vol.13 , pp. 235-244
    • Cahilly, S.L.1    Yang, F.T.2    Francke, U.3    George, D.L.4
  • 9
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh SS, Trusko SP, George DL. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 1991;10:1565-9.
    • (1991) EMBO J , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 13
    • 0028841834 scopus 로고
    • MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adipose-tissue tumors
    • Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki MS. MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. Int J Cancer 1995;64:342-6.
    • (1995) Int J Cancer , vol.64 , pp. 342-346
    • Nakayama, T.1    Toguchida, J.2    Wadayama, B.3    Kanoe, H.4    Kotoura, Y.5    Sasaki, M.S.6
  • 14
    • 0032568334 scopus 로고    scopus 로고
    • Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells
    • Capoulade C, Bressac-de Paillerets B, Lefrere I, Ronsin M, Feunteun J, Tursz T, et al. Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells. Oncogene 1998;16:1603-10.
    • (1998) Oncogene , vol.16 , pp. 1603-1610
    • Capoulade, C.1    Bressac-De Paillerets, B.2    Lefrere, I.3    Ronsin, M.4    Feunteun, J.5    Tursz, T.6
  • 15
    • 0028081261 scopus 로고
    • The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
    • Watanabe T, Hotta T, Ichikawa A, Kinoshita T, Nagai H, Uchida T, et al. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood 1994;84:3158-65.
    • (1994) Blood , vol.84 , pp. 3158-3165
    • Watanabe, T.1    Hotta, T.2    Ichikawa, A.3    Kinoshita, T.4    Nagai, H.5    Uchida, T.6
  • 17
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    • McCann AH, Kirley A, Carney DN, Corbally N, Magee HM, Keating G, et al. Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br J Cancer 1995;71:981-5.
    • (1995) Br J Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1    Kirley, A.2    Carney, D.N.3    Corbally, N.4    Magee, H.M.5    Keating, G.6
  • 18
    • 0029054396 scopus 로고
    • Mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations
    • Marchetti A, Buttitta F, Pellegrini S, Merlo G, Chella A, Angeletti CA, et al. Mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 1995;4:93-7.
    • (1995) Diagn Mol Pathol , vol.4 , pp. 93-97
    • Marchetti, A.1    Buttitta, F.2    Pellegrini, S.3    Merlo, G.4    Chella, A.5    Angeletti, C.A.6
  • 20
    • 0028107586 scopus 로고
    • High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas
    • Lang FF, Miller DC, Pisharody S, Koslow M, Newcomb EW. High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. Oncogene 1994;9:949-54.
    • (1994) Oncogene , vol.9 , pp. 949-954
    • Lang, F.F.1    Miller, D.C.2    Pisharody, S.3    Koslow, M.4    Newcomb, E.W.5
  • 21
    • 0031679407 scopus 로고    scopus 로고
    • Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes
    • Newcomb EW, Cohen H, Lee SR, Bhalla SK, Bloom J, Hayes RL, et al. Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. Brain Pathol 1998;8:655-67.
    • (1998) Brain Pathol , vol.8 , pp. 655-667
    • Newcomb, E.W.1    Cohen, H.2    Lee, S.R.3    Bhalla, S.K.4    Bloom, J.5    Hayes, R.L.6
  • 22
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993;53:2736-9.
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 23
    • 0027978368 scopus 로고
    • Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
    • Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins W. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res 1994;54:4299-303.
    • (1994) Cancer Res , vol.54 , pp. 4299-4303
    • Reifenberger, G.1    Reifenberger, J.2    Ichimura, K.3    Meltzer, P.S.4    Collins, W.5
  • 24
    • 0030970202 scopus 로고    scopus 로고
    • MDM2 and p53 expression in gliomas: A multivariate survival analysis including proliferation markers and epidermal growth factor receptor
    • Korkolopoulou P, Christodoulou P, Kouzelis K, Hadjiyannakis M, Priftis A, Stamoulis G, et al. MDM2 and p53 expression in gliomas: a multivariate survival analysis including proliferation markers and epidermal growth factor receptor. Br J Cancer 1997;75:1269-78.
    • (1997) Br J Cancer , vol.75 , pp. 1269-1278
    • Korkolopoulou, P.1    Christodoulou, P.2    Kouzelis, K.3    Hadjiyannakis, M.4    Priftis, A.5    Stamoulis, G.6
  • 25
    • 0030806772 scopus 로고    scopus 로고
    • Prognostic factors in malignant glioma: Influence of the overexpression of oncogene and tumor-suppressor gene products on survival
    • Rainov NG, Dobberstein KU, Bahn H, Holzhausen HJ, Lautenschlager C, Heidecke V, et al. Prognostic factors in malignant glioma: influence of the overexpression of oncogene and tumor-suppressor gene products on survival. J Neurol Oncol 1997;35:13-28.
    • (1997) J Neurol Oncol , vol.35 , pp. 13-28
    • Rainov, N.G.1    Dobberstein, K.U.2    Bahn, H.3    Holzhausen, H.J.4    Lautenschlager, C.5    Heidecke, V.6
  • 26
    • 0030778862 scopus 로고    scopus 로고
    • Amplification and overexpression of mdm2 in primary (de novo) glioblastomas
    • Biernat W, Kleihues P, Yonekawa Y, Ohgaki H. Amplification and overexpression of mdm2 in primary (de novo) glioblastomas. J Neuropathol Exp Neurol 1997;56:180-5.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 180-185
    • Biernat, W.1    Kleihues, P.2    Yonekawa, Y.3    Ohgaki, H.4
  • 30
    • 0001208039 scopus 로고    scopus 로고
    • Detection of SV40 T antigen genome in human gliomas
    • Suzuki SO, Mizoguchi M, Iwaki T. Detection of SV40 T antigen genome in human gliomas. Brain Tumor Pathol 1997; 14:125-9.
    • (1997) Brain Tumor Pathol , vol.14 , pp. 125-129
    • Suzuki, S.O.1    Mizoguchi, M.2    Iwaki, T.3
  • 31
    • 0028832159 scopus 로고
    • Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue
    • Hunter SB, Abbott K, Varma VA, Olson JJ, Barnett DW, James CD. Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue. J Neuropathol Exp Neurol 1995;54:57-64.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 57-64
    • Hunter, S.B.1    Abbott, K.2    Varma, V.A.3    Olson, J.J.4    Barnett, D.W.5    James, C.D.6
  • 32
    • 0030884358 scopus 로고    scopus 로고
    • Apoptosis and protein expression after focal cerebral ischemia in rat
    • Li Y, Chopp M, Powers C, Jiang N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res 1997;765:301-12.
    • (1997) Brain Res , vol.765 , pp. 301-312
    • Li, Y.1    Chopp, M.2    Powers, C.3    Jiang, N.4
  • 33
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 34
    • 0027244853 scopus 로고
    • The p53-mdm-2 auto-regulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 auto-regulatory feedback loop. Genes Dev 1993;7:1126-32.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 35
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 36
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • Kubbutat M, Jones SN, Vousden KH. Regulation of p53 stability by mdm2. Nature 1997;387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.1    Jones, S.N.2    Vousden, K.H.3
  • 38
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • Landers JE, Haines DS, Strauss J, George DL. Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994;9: 2745-50.
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss, J.3    George, D.L.4
  • 39
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3    Creancier, L.4    Biscan, J.C.5    Valent, A.6
  • 40
    • 0031564954 scopus 로고    scopus 로고
    • P73 is a human p53-related protein that can induce apoptosis
    • Jost CA, Marin MC, Kaelin WG. P73 is a human p53-related protein that can induce apoptosis. Nature 1997;389:191-4.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin, W.G.3
  • 41
    • 0033536230 scopus 로고    scopus 로고
    • Mdm2 binds p73 alpha without targeting degradation
    • Balint E, Bates S, Vousden KH. Mdm2 binds p73 alpha without targeting degradation. Oncogene 1999;18:3923-9.
    • (1999) Oncogene , vol.18 , pp. 3923-3929
    • Balint, E.1    Bates, S.2    Vousden, K.H.3
  • 42
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
    • Dobbelstein M, Wienzek S, Konig C, Roth J. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein. Oncogene 1999;18:2101-6.
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1    Wienzek, S.2    Konig, C.3    Roth, J.4
  • 45
    • 0033605725 scopus 로고    scopus 로고
    • p73 gene transcripts in human brain tumors: Overexpression and altered splicing in ependymomas
    • Loiseau H, Arsaut J, Demotes MJ. p73 gene transcripts in human brain tumors: overexpression and altered splicing in ependymomas. Neurosci Lett 1999;263:173-6.
    • (1999) Neurosci Lett , vol.263 , pp. 173-176
    • Loiseau, H.1    Arsaut, J.2    Demotes, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.