Oxidised lipids present in ascitic fluid interfere with the regulation of the macrophages during acute pancreatitis, promoting an exacerbation of the inflammatory response

Gut

Volumn 57, Issue 5, 2008, Pages 642-648

  Gutierrez, P T ^a   Folch Puy, E ^a   Bulbena, O ^a   Closa, Daniel ^a,b  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TAUROCHOLIC ACID;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES FLUID; ASCITES FLUID LEVEL; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE EXACERBATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LIPID COMPOSITION; LIPID PEROXIDATION; LIVER CELL; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 42549152908     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.127472     Document Type: Article

References (28)

1. Klöppel G, Maillet B. Pathology of acute and chronic pancreatitis. Pancreas 1993;8:659-70.
2. Niederau C, Crass RA, Silver G, et al. Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor. Gastroenterology 1988;95:1648-57.
3. Satoh A, Shimosegawa T, Masamune A, et al. Ascitic fluid of experimental severe acute pancreatitis modulates the function of peritoneal macrophages. Pancreas 1999;19:268-75.
4. Fujita M, Masamune A, Satoh A, et al. Ascites of a rat experimental model of severe acute pancreatitis induces lung injury. Pancreas 2001;22:409-18.
5. Murr MM, Yang J, Fier A, et al. Pancreatitis-associated ascitic fluid induces hepatocyte death independent of local cytokines. J Surg Res 2002;106:308-13.
6. Ramudo L, Manso MA, De Dios I. Biliary pancreatitis-associated ascitic fluid activates the production of tumor necrosis factor-alpha in acinar cells. Crit Care Med 2005;33:143-8.
7. Platell C, Cooper D, Hall JC. A meta-analysis of peritoneal lavage for acute pancreatitis. J Gastroenterol Hepatol 2001;16:689-93.
8. Pappas TN, Gavino VC, Ellison EC, et al. Concentration of FFA in pancreatitis-associated ascitic fluid. Clin Chem 1981;27:358.
9. Cnop M, Hannaert JC, Hoorens A, et al. Inverse relationship between cytotoxicity of FFA in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001;50:1771-7.
10. Dersch K, Ichijo H, Bhakdi S, et al. Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases. Cell Death Differ 2005;12:1107-14.
11. Rizzo G, Fiorucci S. PPARs and other nuclear receptors in inflammation. Curr Opin Pharmacol 2006;6:421-7.
12. Kliewer SA, Sundseth SS, Jones SA, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA 1997;94:4318-23.
13. Scher JU, Pillinger MH. 15d-PGJ2: the anti-inflammatory prostaglandin? Clin Immunol 2005;114:100-9.
14. Aho HJ, Koskensalo SML, Nevalainen TJ. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute hemorrhagic pancreatitis. Scand J Gastroenterol 1980;15:411-6.
15. Folch E, Closa D, Prats N, et al. Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis. Inflammation 1998;22:83-93.
16. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-7.
17. Bioque G, Tost D, Closa D, et al. Concurrent C18 solid phase extraction of platelet activating factor (PAF) and arachidonic acid metabolites. J Liq Chromatogr 1992;15:1249-58.
18. Hamilton JG, Komai K. Separation of neutral lipids and FFA by high-performance liquid chromatography using low wavelength ultraviolet detection. J Lipid Res 1984;25:1142-8.
19. Jha HV, von Recklinghausen G, Zilliken F. Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids. Biochem Pharmacol 1985;34:1367-9.
20. Sanfey H, Bulkley GB, Cameron JL. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann Surg 1984;200:405-13.
21. Tsai K, Wang SS, Chen TS, et al. Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis. Gut 1998;42:850-5.
22. Mikami Y, Takeda K, Shibuya K, et al. Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats? Pancreas 2003;27:253-60.
23. Kyosola K, Fock G. Complications in acute pancreatitis. Ann Chir Gynaecol Suppl 1976;65:7-12.
24. Takacs P, Kauma SW, Sholley MM, et al. Increased circulating lipid peroxides in severe preeclampsia activate NF-{kappa}B and upregulate ICAM-1 in vascular endothelial cells. FASEB J 2001;15:279-81.
25. Nencioni A, Wesselborg S, Brossait P. Role of peroxisome proliferator-activated receptor gamma and its ligands in the control of immune responses. Crit Rev Immunol 2003;23(1-2):1-13.
26. Giri S, Rattan R, Singh AK, et al. The 15-deoxy-delta 12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol 2004;173:5196- 208.
27. Cuzzocrea S, Pisano B, Dugo L, et al. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein. Intensive Care Med 2004;5:951-6.
28. Folch-Puy E, Granell S, Iovanna JL, et al. Peroxisome proliferator-activated receptor gamma agonist reduces the severity of post-ERCP pancreatitis in rats. World J Gastroenterol 2006;12:6458-63.