The role of COX-2 in rectal cancer treated with preoperative radiotherapy

Virchows Archiv

Volumn 452, Issue 5, 2008, Pages 499-505

  Bouzourene, Hanifa ^a   Yan, Pu ^a   Sandmeier, Dominique ^a   Zouhair, Abderrahim ^a   Matter, Maurice ^a   Vuilleumier, Henri ^a   Coucke, Philippe ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

Cyclooxygenase 2; Radiotherapy; Rectal cancer; Recurrence; Survival

Indexed keywords

CYCLOOXYGENASE 2;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER SURGERY; CANCER SURVIVAL; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CANCER; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CYCLOOXYGENASE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PREOPERATIVE CARE; PROGNOSIS; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 42549128752     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-008-0606-9     Document Type: Article

References (48)

1. Bosset JF, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Briffaux A, Collette L (2005) Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results-EORTC 22921. J Clin Oncol 23:5620-5627
2. Bouzourene H, Bosman FT, Seelentag W, Matter M, Coucke P (2002) Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma treated with preoperative radiotherapy. Cancer 94:1121-1130
3. Chan G, Boyle JO, Yang EK, Zhang F, Sacks PG, Shah JP, Edelstein D, Soslow RA, Koki AT, Woerner BM, Masferrer JL, Dannenberg AJ (1999) Cyclooxigenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res 5:991-994
4. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD (1997) Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A 94:657-662
5. Coucke P, Notter M, Stamm B, Matter M, Fasolini F, Schlumpf R, Matzinger O, Bouzourene H (2006) Preoperative hyperfractionated acccelerated radiotherapy (HART) in locally advanced rectal cancer (LARC) immediately followed by surgery. A prospective phase II trial. Radiother Oncol 79:52-58
6. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE (1998) Cyclooxygenase in biology and disease. FASEB J 12:1063-1073
7. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, Dubois RN (1994) Up-regulation of cyclooxigenase-2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107:1183-1188
8. Fux R, Schwab M, Thon KP, Gleiter CH, Fritz P (2005) Cycloooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. Clin Cancer Res 11:4754-4760
9. Gaffney DK, Holden J, Davis M, Zempolich K, Murphy KJ, Dodson M (2001) Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys 49:1213-1217
10. Gérard JP, Conroy T, Bonnetain F, Bouché O, Chapet O, Closon-Dejardin MT, Untereiner M, Leduc B, Francois E, Maurel J, Seitz JF, Buecher B, Mackiewicz R, Ducreux M, Bedenne L (2006) Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 24:4620-4625
11. Glimelius B (2003) Role of adjuvant chemoradiotherapy for abdominal malignancies. Dig Surg 20:169-179
12. Heald RJ, Ryall RD (1986) Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1:1479-1482
13. Hermanek P, Hermanek PJ (2000) Role of the surgeon as a variable in the treatment of rectal cancer. Sem Surg Oncol 19:325-329
14. Herschman HR, Xie W, Reddy S (1995) Inflammation, reproduction, cancer and all that. The regulation and role of the inducible prostaglandin synthase. Bioessays 17:1031-1037
15. Joo YE, Kim HS, Min SW, Lee WS, Park CH, Park CS, Choi SK, Rew JS, Kim SJ (2002) Expression of cyclooxygenase-2 protein in colorectal carcinomas. Int J Gastrointest Cancer 31:147-154
16. Kapiteijn E, Putter H, van de Velde CJH and cooperative investigators of the Dutch Colorectal Cancer Group (2002) Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in the Netherlands. cooperative investigators of the Dutch Colorectal Cancer Group Br J Surgery 89:1142-1149
17. Kapiteijn E, Marijnen CA, Nagtegall ID Putter H, Steup WH, Wiggers T, Rutten HJ, Pahlman L, Glimelius B, van Krieken JH, Leer JW, van de Velde CJ, Dutch Colorectal Cancer Group (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638-646
18. Kim YB, Kim GE, Cho NH, Cho HC, Pyo HR, Lee JD, Park TK, Koom WS, Chun M, Suh CO (2002) Overexpression of cyclooxigenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. Cancer 95:531-539
19. Kishi K, Petersen S, Petersen C, Hunter N, Mason K, Masferrer JL, Tofilon PJ, Milas L (2000) Preferential enhancement of tumor radioresponse by an inhibitor of cyclooxygenase-2 inhibitor. Cancer Res 60:1326-1331
20. Konno H, Baba M, Shoji T, Ohta M, Suzuki S, Nakamura S (2002) Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. Clin Exp Metastasis 19:527-534
21. Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, Edwards DA, Flickinger AG, Moore RJ, Seibert K (2000) Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res 60:1306-1311
22. Masunaga R, Kohno H, Dhar DK, Ohno S, Shibakita M, Kinugasa S, Yoshimura H, Tachibana M, Kubota H, Nagasue N (2000) Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. Clin Cancer Res 6:4064-4068
23. Milas L, Kishi K, Hunter N, Mason K (1999) Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme. J Natl Cancer Inst 91:1501-1504
24. Milas L (2003) Cyclooxygenase-2 (COX-2) enzyme inhibitors and radiotherapy: preclinical basis. Am J Clin Oncol 26:S66-69
25. Milas L, Mason KA, Crane CH, Liao Z, Masferrer J (2003) Improvement of radiotherapy or chemoradiotherapy by targeting COX-2 enzyme. Oncology 17:15-24
26. Nakata E, Mason KA, Hunter N, Husain A, Raju U, Liao Z, Ang KK, Milas L (2004) Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. Int J Radiat Oncol Biol Phys 58:369-375
27. Nix P, Lind M, Greenman J, Stafford N, Cawkwell L (2004) Expression of Cox-2 protein in radioresistant laryngeal cancer. Ann Oncol 15:797-801
28. Petersen S, Haroske G, Hellmich G, Ludwig K, Petersen C, Eicheler W (2002) COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. Anticancer Res 22:1225-1230
29. Pyo H, Choy H, Amorino GP, Kim JS, Cao Q, Hercules SK, DuBois RN (2001) A selective cyclooxigenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res 7:2998-3005
30. Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adeocarcinoma due to inadequate surgical resection: histopathological study of lateral tumor spread and surgical excision. Lancet 2:996-999
31. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T (1995) Expression of cyclooxygenase-1 and-2 in human colorectal cancer. Cancer Res 55:3785-3789
32. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. German Rectal Cancer Study Group N Engl J Med 17:1731-1740
33. Sheehan KM, Sheahan K, O'Donoghue DP, MacSweeney F, Conroy RM, Fitzgerald DJ, Murray FE (1999) The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA 282:1254-1257
34. Smith WL, Garavito RM, Dewitt DL (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:33157-33160
35. Sobin LH, Wittekind C (eds) (1997) TNM Classification of malignant tumours. 5th ed. John Wiley & Sons, New York
36. Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K (2004) Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res 10:8465-8471
37. Steinauer KK, Gibbs I, Ning S, French JN, Armstrong J, Knox SJ (2000) Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells. Int J Radiat Oncol Biol Phys 48:325-328
38. Swedish Rectal Cancer Trial (1997) Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 336:980-987
39. Terakado N, Shintani S, Yano J, Chunnan L, Mihara M, Nakashiro K, Hamakawa H (2004) Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. Oral Oncol 40:383-389
40. Tomozawa S, Tsuno NH, Sunami E, Hatano K, Kitayama J, Osada T, Saito S, Tsuruo T, Shibata Y, Nagawa H (2000) Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. Br J Cancer 83:324-328
41. Tsujii M, Dubois R (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cell 83:493-501
42. Tsujii M, Kawano S, Dubois R (1997) Cyclooxigenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci U S A 94:3336-3340
43. Tucker ON, Dannenberg AJ, Yang EK, Zhang F, Teng L, Daly JM, Soslow RA, Masferrer JL, Woerner BM, Koki AT, Fahey TJ 3rd (1999) Cyclooxigenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res 59:987-990
44. Wambura C, Aoyama N, Shirasaka D, Kuroda K, Maekawa S, Ebara S, Watanabe Y, Tamura T, Kasuga M (2002) Effect of Helicobacter pylori-induced cyclooxygenase-2 on gastric epithelial cell kinetics: implication for gastric carcinogenesis. Helicobacter 7:129-138
45. Watwe V, Javle M, Lawrence D, Groth J, Iyer R, El-Hajjar D, Geradts J (2005) Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. Am J Clin Oncol 28:560-564
46. Williams CS, Mann M, Dubois RN (1999) The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 18:7908-7916
47. World Health Organization (1988) International histological classification of tumours. 2nd ed. Geneva: World Health Organization, 1969-1981. Springer-Verlag, Berlin
48. Zhang H, Sun XF (2002) Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. Am J Gastroenterol 97:1037-1041