Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver

Drug Metabolism and Disposition

Volumn 36, Issue 5, 2008, Pages 885-893

  Giantin, Mery ^a   Carletti, Monica ^b   Capolongo, Francesca ^a   Pegolo, Sara ^a   Lopparelli, Rosa Maria ^a   Gusson, Federica ^b   Nebbia, Carlo ^b   Cantiello, Michela ^b   Martin, Pascal ^c   Pineau, Thierry ^c   Dacasto, Mauro ^a,d  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c CEMAGREF   (France)

^d Facoltà di Medicina Veterinaria   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1 NAPHTHOL; 1,2 DICHLORO 4 NITROBENZENE; 16 BETA TESTOSTERONE HYDROXYLASE; 2 BETA TESTOSTERONE HYDROXYLASE; 4 NITROPHENOL; 4 NITROPHENOL HYDROXYLASE; 6 BETA TESTOSTERONE HYDROXYLASE; ANILINE; BENZPHETAMINE DEMETHYLASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C18; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREED; CATALYSIS; CATTLE; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CATTLE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIVER; MALE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RNA, MESSENGER; SPECIES SPECIFICITY;

ANIMALIA; BOS;

EID: 42449155535     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019042     Document Type: Article

References (39)

1. Cantiello M, Carletti M, Dacasto M, Capolongo F, Gardini G, Cascio P, Martin PGP, Pineau T, and Nebbia C (2006) Catalytic, immunochemical and molecular characterization of xenobiotic-metabolising enzyme modulation by phenobarbital in the bovine liver. J Vet Pharmacol Ther 29 (Suppl 1):115-116.
2. Cantiello M, Giantin M, Bollo E, Nebbia C, Lasserre F, Martin P, Pineau T, and Dacasto M (2005) Cloning and sequencing of some relevant drug metabolism genes in cattle: the Programma Galileo 2003 summary report. Pharmacologyonline 3:66-76.
3. Capolongo F, Merlanti R, Cibin V, De Liguoro M, and Montesissa C (2003) In vivo hormone treatments in calves: effects on in vitro hydroxylation of testosterone. J Vet Pharmacol Ther 26 (Suppl 1):159-160.
4. Casley WL, Menzies JA, Girard M, Larocque L, Mousseau N, Whitehouse LW, and Moon TW (1997) Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic cyp1a2 gene expression between two inbred strains. Fundam Appl Toxicol 40:228-237.
5. Dacasto M, Eeckhoutte C, Capolongo F, Dupuy J, Carletti M, Calléja C, Nebbia C, Alvinerie M, and Galtier P (2005) Effect of breed and gender on bovine liver cytochrome P450 3° (CYP3A) expression and inter-species comparison with other domestic ruminants. Vet Res 36:179-190.
6. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77.
7. Frova C (2006) Glutathione transferases in the genomics era: new insights and perspectives. Biomol Eng 23:149-169.
8. Greger DL, Philipona C, and Blum JW (2006) Ontogeny of mRNA abundance of nuclear receptors and nuclear receptor target genes in young cattle. Domest Anim Endocrinol 31:76-87.
9. Gusson F, Carletti M, Giuliano Albo A, Dacasto M, and Nebbia C (2006) Comparison of hydrolitic and conjugative biotransformations pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellular fractions. Vet Res Commun 30:271-283.
10. Hanioka N, Tatarazako N, Jinno H, Arizono K, and Ando M (2000) Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection. J Chromatogr B 744:399-406.
11. Ioannides C (2006) Cytochrome P450 expression in the liver of food-producing animals. Curr Drug Metab 7:335-348.
12. Jang I, Chae K, and Cho J (2001) Effects of age and strain on small intestinal and hepatic antioxidant defence enzymes in Wistar and Fisher 344 rats. Mech Ageing Dev 122:561-570.
13. Katoh M, Matsui T, Okumura H, Nakajima M, Nishimura M, Naito S, Tateno C, Yoshizato K, and Yokoi T (2005) Expression of human phase II enzymes in chimeric mice with humanized liver. Drug Metab Dispos 33:1333-1340.
14. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
15. Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
16. Löfgren S, Hagbjörk AL, Ekman S, Fransson-Steen R, and Terelius Y (2004) Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica 34:811-834.
17. Lowry O, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
18. Machala M, Souček P, Neča J, Ulrich R, Lamka J, Szotáková B, and Skálová (2003) Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants. Arch Toxicol 77:555-560.
19. Nagar S and Remmel RP (2006) Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. Oncogene 25:1659-1672.
20. Nebbia C (2001) Biotransformation enzymes as determinants of xenobiotic toxicity in domestic animals. Vet J 161:238-252.
21. Nebbia C, Dacasto M, and Carletti M (2004) Postnatal development of hepatic oxidative, hydrolytic and conjugative drug-metabolizing enzymes in female horses. Life Sci 74:1605-1619.
22. Nebbia C, Dacasto M, Rossetto Giaccherino A, Giuliano Albo A, and Carletti M (2003) Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species. Vet J 165:53-64.
23. Oesch-Bartlomowicz B and Oesch F (2005) Phosphorylation of cytochromes P450: first discovery of a posttranslational modification of a drug-metabolizing enzyme. Biochem Biophys Res Commun 338:446-449.
24. Palamanda J, Feng WW, Lin CC, and Nomeir AA (2000) Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system. Drug Metab Dispos 28:38-43.
25. Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, and Rusyn I (2007) Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci 99:315-325.
26. Saito K, Sakai N, Kim HS, Ishizuka M, Kazusaka A, and Fujita S (2004) Strain differences in diazepam metabolism at its three metabolic sites in Sprague-Dawley, Brown Norway, Dark Agouti and Wistar strain rats. Drug Metab Dispos 32:959-965.
27. Sallovitz J, Lifschitz A, Imperiale F, Pis A, Virkel G, and Lanusse C (2002) Breed differences on the plasma availability of moxidectin administered pour-on to calves. Vet J 164:47-53.
28. Schwerin M, Kuehn C, Wimmers S, Walz C, and Goldammer T (2006) Trait-associated expressed hepatic and intestine genes in cattle of different metabolic type: putative functional candidates for nutrient utilization. J Anim Breed Genet 123:307-314.
29. Sivapathasundaram S, Magnisali P, Coldham NG, Howells LC, Sauer MJ, and Ioannides C (2001) A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and testosterone metabolism in bovine liver. Biochem Pharmacol 62:635-645.
30. Sivapathasundaram S, Magnisali P, Coldham NG, Howells LC, Sauer MJ, and Ioannides C (2003a) Cytochrome P450 expression and testosterone metabolism in the liver of deer. Toxicology 187:49-65.
31. Sivapathasundaram S, Sauer MJ, and Ioannides C (2003b) Xenobiotic conjugation system in deer compared with cattle and rat. Comp Biochem Physiol C Toxicol Pharmacol 134:169-173.
32. Stott WT, Kan HL, McFadden LG, Sparrow BR, and Gollapudi BB (2004) Effect of strain and diet upon constitutive and chemically induced activities of several xenobiotic-metabolizing enzymes in rats. Regul Toxicol Pharmacol 39:325-333.
33. Szotáková B, Baliharová V, Lamka J, Nožinová E, Wsól V, Velík J, Machala M, Neča J, Souček P, Šusová S, et al. (2004) Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep. Res Vet Sci 76:43-51.
34. Thomford PJ and Dziuk PJ (1986) The influence of dose of Phenobarbital and intervals to measurement on concentration of liver enzymes in barrows and gilts. J Anim Sci 63:1184-1190.
35. Towbin H, Staehelin T, and Gordon J (1979) Electrophoretic transfert of proteins from polyacrilamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354.
36. Tsuchiya Y, Nakajima M, Takagi S, Taniya T, and Yokoi T (2006) MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res 66:9090-9098.
37. 5 in the upper airways in horse. Res Vet Sci, in press.
38. Wang H, Huang M, Peng R, and Le J (2006) Influences of 3-methylcholanthrene, Phenobarbital and dexamethasone on xenobiotic metabolizing-related cytochrome P450 enzymes and steroidogenesis in human fetal adrenal cortical cells. Acta Pharmacol Sin 27:1093-1096.
39. Xu C, Yong-Tao Li C, and Tony Kong AN (2005) Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharmacol Res 28:249-268.