Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway

Journal of Cardiovascular Pharmacology

Volumn 51, Issue 4, 2008, Pages 388-395

  Qiu, Guosong ^a,b   Hill, John S ^a,b  

^a ST PAUL S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Atorvastatin; ATP binding cassette transporter A1; Cholesterol efflux; Liver X receptor; Macrophage; Rho protein

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; ATORVASTATIN; CHOLESTEROL; CHOLESTEROL DERIVATIVE; EXOENZYME C3; FARNYSYLPYOPHOSPHATE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; MEVALONIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATE; RHO FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOAM CELLS; GENE EXPRESSION REGULATION; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPOPROTEINS, LDL; MACROPHAGE ACTIVATION; MACROPHAGES; PYRROLES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE;

EID: 42449149208     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318167141f     Document Type: Article

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