Effects of ubiquitin-proteasome system deregulation on the vascular senescence and atherosclerosis process in elderly patients

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 63, Issue 2, 2008, Pages 200-203

  Marfella, Raffaele ^a,c   Di Filippo, Clara ^a   Laieta, Maria Teresa ^a   Vestini, Rosanna ^a   Barbieri, Michelangela ^a   Sangiulo, Paolo ^b   Crescenzi, Basilio ^b   Ferraraccio, Franca ^a   Rossi, Francesco ^a   D'Amico, Michele ^a   Paolisso, Giuseppe ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b MONALDI HOSPITAL   (Italy)

^c NONE   (Italy)

Author keywords

Atherosclerosis; Ubiquitin proteasome

Indexed keywords

3 NITROTYROSINE; CD3 ANTIBODY; CHLORDANE; GELATINASE B; HLA ANTIBODY; HLA DR ANTIGEN; PROTEASOME; PROTEIN P16; PROTEIN P53; UBIQUITIN; 3-NITROTYROSINE; COLLAGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA BINDING PROTEIN; DRUG DERIVATIVE; PDRG1 PROTEIN, HUMAN; TYROSINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; MALE; NITROSYLATION; PRIORITY JOURNAL; SENESCENCE; UBIQUITINATION; AGING; COMPARATIVE STUDY; DISEASE COURSE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

AGED; AGING; ATHEROSCLEROSIS; COLLAGEN; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PROTEASOME ENDOPEPTIDASE COMPLEX; TYROSINE; UBIQUITIN;

EID: 42449136233     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/63.2.200     Document Type: Article

References (21)

1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: a "set up" for vascular disease. Circulation. 2003;107:139-146.
2. Braunwald E, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th Ed. Philadelphia, PA: Saunders; 2005.
3. Faragher RG, Kipling D. How might replicative senescence contribute to human ageing? Bioessays. 1998;20:985-991.
4. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120:513-522.
5. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ Res. 2001;89:793-798.
6. Unterluggauer H, Hampel B, Zwerschke W, Jansen-Durr P. Senescence-associated cell death of human endothelial cells: the role of oxidative stress. Exp Gerontol. 2003;38:1149-1160.
7. Minamino T, Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res. 2007;100:15-26.
8. Martinez-Vicente M, Sovak G, Cuervo AM. Protein degradation and aging. Exp Gerontol. 2005;40:622-633.
9. Grillari J, Katinger H, Voglauer R. Aging and the ubiquitinome: traditional and non-traditional functions of ubiquitin in aging cells and tissues. Exp Gerontol. 2006;41:1067-1079.
10. Herbig U, Sedivy JM. Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev. 2006;127:16-24.
11. Smogorzewska A, van Steensel B, Bianchi A, et al. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol. 2000;20:1659-1668.
12. Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance, J Biol Chem. 2006;281:759-768.
13. Yang Y, Loscalzo J. S-nitrosoprotein formation and localization in endothelial cells. Proc Natl Acad Sci U S A. 2005;102:117-122.
14. Kyng KJ, Bohr VA. Gene expression and DNA repair in progeroid syndromes and human aging. Ageing Res Rev. 2005;4:579-602.
15. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation. 2002;105:1541-1544.
16. Herrmann J, Ciechanover A, Lerman LO, Lerman A. The ubiquitin-proteasome system in cardiovascular diseases - a hypothesis extended. Cardiovasc Res. 2004;61:11-21.
17. Marfella R, D'Amico M, Di Filippo C, et al. Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment. J Am Coll Cardiol. 2006;47:2444-2455.
18. Marfella R, D'Amico M, Esposito K, et al. The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment. Diabetes. 2006;55:622-632.
19. Chondrogianni N, Stratford FL, Trougakos IP, Friguet B, Rivett AJ, Gonos ES. Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem. 2003;278:28026-28037.
20. Martinez-Vicente M, Sovak G, Cuervo AM. Protein degradation and aging. Exp Gerontol. 2005;40:622-633.
21. Hyun DH, Lee MH, Halliwell B. Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: a mechanism contributing to neurodegeneration? J Neurochem. 2002;83:360-370.