Severe obesity and insulin resistance due to deletion of the maternal Gsα allele is reversed by paternal deletion of the G sα imprint control region

Endocrinology

Volumn 149, Issue 5, 2008, Pages 2443-2450

  Xie, Tao ^a   Chen, Min ^a   Gavrilova, Oksana ^a   Lai, Edwin W ^b   Liu, Jie ^a   Weinstein, Lee S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE DELETION; GENOME IMPRINTING; HISTOPATHOLOGY; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL;

ALLELES; ANIMALS; EDEMA; ENERGY METABOLISM; EXONS; FATHERS; FEMALE; GENE DELETION; GENES, LETHAL; GENOMIC IMPRINTING; GLUCOSE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; INHERITANCE PATTERNS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MICE; MICE, TRANSGENIC; MOTHERS; OBESITY, MORBID; REGULATORY SEQUENCES, NUCLEIC ACID; SKIN DISEASES;

EID: 42449121047     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1458     Document Type: Article

References (34)

1. Farooqi S, O'Rahilly S 2006 Genetics of obesity in humans. Endocr Rev 27:710-718
2. Weinstein LS 2004 GNAS and McCune-Albright syndrome/fibrous dysplasia, Albright hereditary osteodystrophy/pseudohypoparathyroidism type 1A, progressive osseous heteroplasia, and pseudohypoparathyroidism type 1B. In: Epstein CJ, Erickson RP, Wynshaw-Boris A, eds. Molecular basis of inborn errors of development. 1st ed. San Francisco: Oxford University Press; 849-866
3. Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS 2005 Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci USA 102:7386-7391
4. Germain-Lee EL, Ding C, Deng Z, Crane JL, Saji M, Ringel MD, Levine MA 2002 Paternal imprinting of Gαs in the human thyroid as the basis of TSH resistance in pseudohypoparathyroidism type 1a. Biochem Biophys Res Commun 296:67-72
5. sα is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B. J Clin Endocrinol Metab 88:4336-4341
6. sα gene. Proc Natl Acad Sci USA 95:8715-8720
7. sα gene GNAS1 in the pathogenesis of acromegaly. J Clin Invest 107:R31-R36
8. Mantovani G, Ballare E, Giammona E, Beck-Peccoz P, Spada A 2002 The Gsα gene: predominant maternal origin of transcription in human thyroid gland and gonads. J Clin Endocrinol Metab 87:4736-4740
9. sα gene Gnas using gene targeting technology. Pharmacol Ther 115:271-291
10. Germain-Lee EL, Schwindinger W, Crane JL, Zewdu R, Zweifel LS, Wand G, Huso DL, Saji M, Ringel MD, Levine MA 2005 A mouse model of Albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene. Endocrinology 146:4697-4709
11. Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K, Parlow AF, Quon MJ, Reitman ML, Weinstein LS 2000 Paternal versus maternal transmission of a stimulatory G protein α subunit knockout produces opposite effects on energy metabolism. J Clin Invest 105:615-623
12. Plagge A, Gordon E, Dean W, Boiani R, Cinti S, Peters J, Kelsey G 2004 The imprinted signaling protein XLαs is required for postnatal adaptation to feeding. Nat Genet 36:818-826
13. Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW, Frontera M, Kelsey G, Weinstein LS 2006 The alternative stimulatory G protein α-subunit XLαs is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem 281:18989-18999
14. Plagge A, Isles AR, Gordon E, Humby T, Dean W, Gritsch S, Fischer-Colbrie R, Wilkinson LS, Kelsey G 2005 Imprinted Nesp55 influences behavioral reactivity to novel environments. Mol Cell Biol 25:3019-3026
15. Liu J, Litman D, Rosenberg MJ, Yu S, Biesecker LG, Weinstein LS 2000 A GNAS1 imprinting defect in pseudohypoparathyroidism type IB. J Clin Invest 106:1167-1174
16. Liu J, Yu S, Litman D, Chen W, Weinstein LS 2000 Identification of a methylation imprint mark within the mouse Gnas locus. Mol Cell Biol 20:5808-5817
17. Hayward BE, Kamiya M, Strain L, Moran V, Campbell R, Hayashizaki Y, Bonthron DT 1998 The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins. Proc Natl Acad Sci USA 95:10038-10043
18. Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS 2005 Identification of the control region for tissue-specific imprinting of the stimulatory G protein α-subunit. Proc Natl Acad Sci USA 102:5513-5518
19. Williamson CM, Ball ST, Nottingham WT, Skinner JA, Plagge A, Turner MD, Powles N, Hough T, Papworth D, Fraser WD, Maconochie M, Peters J 2004 A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas. Nat Genet 36:894-899
20. Eisenhofer G, Goldstein DS, Stull R, Keiser HR, Sunderland T, Murphy DL, Kopin IJ 1986 Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clin Chem 32:2030-2033
21. Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-γ coactivator 1a (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90
22. Williamson CM, Beechey CV, Papworth D, Wroe SF, Wells CA, Cobb L, Peters J 1998 Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero. Genet Res 72:255-265
23. Fowden AL, Sibley C, Reik W, Constancia M 2006 Imprinted genes, placental development and fetal growth. Horm Res 65(Suppl 3):50-58
24. sα knockout mice. J Biol Chem 276:19994-19998
25. sα deficiency. J Clin Invest 115:3217-3227
26. Mantovani G, Bondioni S, Locatelli M, Pedroni C, Lania AG, Ferrante E, Filopanti M, Beck-Peccoz P, Spada A 2004 Biallelic expression of the Gsα gene in human bone and adipose tissue. J Clin Endocrinol Metab 89:6316-6319
27. Williamson CM, Turner MD, Ball ST, Nottingham WT, Glenister P, Fray M, Tymowska-Lalanne Z, Plagge A, Powles-Glover N, Kelsey G, Maconochie M, Peters J 2006 Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Nat Genet 38:350-355
28. sα are resistant to diet-induced obesity and maintain diet-induced, but not coldinduced, thermogenesis. Diabetes 55(Suppl 1):A71 (Abstract)
29. sα leads to reduced β cell mass and insulin-deficient diabetes. Proc Natl Acad Sci USA 104:19601-19606
30. Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y 2007 Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. FEBS Lett 581:1131-1136
31. Phan LK, Chung WK, Leibel RL 2006 The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 291:E611-E620
32. Song CK, Jackson RM, Harris RB, Richard D, Bartness TJ 2005 Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. Am J Physiol 289:R1467-R1476
33. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505
34. Smith FM, Garfield AS, Ward A 2006 Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 113:279-291