Increased plasma leptin in antipsychotic-naïve females with schizophrenia, but not in males

Neuropsychobiology

Volumn 56, Issue 4, 2008, Pages 213-215

  Wang, Hsuan Chi ^b   Yang, Yen Kuang ^a,b   Chen, Po See ^a,b   Lee, I Hui ^a,b   Yeh, Tzung Lieh ^a,b   Lu, Ru Band ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Antipsychotic na ve patients; Leptin; Schizophrenia

Indexed keywords

INSULIN; LEPTIN; NEUROLEPTIC AGENT;

AGGRESSION; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISEASE DURATION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; NEGATIVE SYNDROME; OUTPATIENT; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOSIS; RATING SCALE; RISK ASSESSMENT; SCHIZOPHRENIA; SEX DIFFERENCE;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; FEMALE; HUMANS; LEPTIN; MALE; SCHIZOPHRENIA; SEX CHARACTERISTICS; STATISTICS, NONPARAMETRIC;

EID: 42449112378     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000122267     Document Type: Article

References (27)

1. Melkersson KI, Hulting AL: Insulin and leptin levels in patients with schizophrenia or related psychoses - A comparison between different antipsychotic agents. Psychopharmacology 2001;154:205-212.
2. Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G: Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry 2002;59:337-345.
3. Wang HC, Chen PS, Lee IH, Yang YK, Yeh TL, Lu RB: Rapid leptin elevation after initiation of olanzapine? Neuropsychobiology 2006;54:182-185.
4. Thakore JH, Mann JN, Vlahos I, Martin A, Reznek R: Increased visceral fat distribution in drug-naive and drug-free patients with schizophrenia. Int J Obes Relat Metab Disord 2002;26:137-141.
5. Ryan MC, Collins P, Thakore JH: Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am J Psychiatry 2003;160:284-289.
6. Perneger TV: What's wrong with Bonferroni adjustments. BMJ 1998;316:1236-1238.
7. Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmacher T: Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 2001;73:243-247.
8. Atmaca M, Kuloglu M, Tezcan E, Ustundag B: Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr Scand 2003;108:208-214.
9. Arranz B, Rosel P, Ramirez N, Duenas R, Fernandez P, Sanchez JM, Navarro MA, San L: Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients. J Clin Psychiatry 2004;65:1335-1342.
10. Jow GM, Yang TT, Chen CL: Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord 2006;90:21-27.
11. van Erp AM, Miczek KA: Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats. J Neurosci 2000;20:9320-9325.
12. Giegling I, Hartmann AM, Moller HJ, Rujescu D: Anger- and aggression-related traits are associated with polymorphisms in the 5-ht-2a gene. J Affect Disord 2006;96:75-81.
13. Frankle WG, Lombardo I, New AS, Goodman M, Talbot PS, Huang Y, Hwang DR, Slifstein M, Curry S, Abi-Dargham A, Laruelle M, Siever LJ: Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. Am J Psychiatry 2005;162:915-923.
14. Calapai G, Corica F, Corsonello A, Sautebin L, Di Rosa M, Campo GM, Buemi M, Mauro VN, Caputi AP: Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest 1999;104:975-982.
15. Cota D, Barrera JG, Seeley RJ: Leptin in energy balance and reward: two faces of the same coin? Neuron 2006;51:678-680.
16. Diano S, Kalra SP, Sakamoto H, Horvath TL: Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus. Brain Res 1998;812:256-259.
17. Atmaca M, Kuloglu M, Tezcan E, Ustundag B: Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr Scand 2003;108:208-214.
18. Ahima RS, Bjorbaek C, Osei S, Flier JS: Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 1999;140:2755-2762.
19. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005;11:191-198.
20. Esler M, Vaz M, Collier G, Nestel P, Jennings G, Kaye D, Seals D, Lambert G: Leptin in human plasma is derived in part from the brain, and cleared by the kidneys. Lancet 1998;351:21.
21. Harrold JA: Leptin leads hypothalamic feeding circuits in a new direction. Bioessays 2004;26:1043-1045.
22. Harvey J, Shanley LJ, O'Malley D, Irving AJ: Leptin: a potential cognitive enhancer? Biochem Soc Trans 2005;33:1029-1032.
23. Shanley LJ, Irving AJ, Harvey J: Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 2001;21:RC186.
24. Wiesner G, Vaz M, Collier G, Seals D, Kaye D, Jennings G, Lambert G, Wilkinson D, Esler M: Leptin is released from the human brain: influence of adiposity and gender. J Clin Endocrinol Metab 1999;84:2270-2274.
25. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS: Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006;51:811-822.
26. Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ: Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006;51:801-810.
27. Carraro R, Ruiz-Torres A: Relationship of serum leptin concentration with age, gender, and biomedical parameters in healthy, non-obese subjects. Arch Gerontol Geriatr 2006;43:301-312.