The effects of general anesthesia on whole body and regional pharmacokinetics of local anesthetics at toxic doses

Anesthesia and Analgesia

Volumn 106, Issue 5, 2008, Pages 1440-1449

  Copeland, Susan E ^a   Ladd, Leigh A ^a   Gu, Xiao Qing ^a   Mather, Laurence E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; HALOTHANE; LEVOBUPIVACAINE; LIDOCAINE; MEPIVACAINE; PRILOCAINE; ROPIVACAINE; AMIDE; DRUG DERIVATIVE; INHALATION ANESTHETIC AGENT; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN VEIN; CARDIOVASCULAR DISEASE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG FATALITY; DRUG POTENTIATION; DRUG UPTAKE; ENANTIOSELECTIVITY; EWE; EXCITOTOXICITY; GENERAL ANESTHESIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LOCAL ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; ANIMAL; BIOLOGICAL MODEL; BLOOD; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; DRUG INTERACTION; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; METABOLISM; PROTEIN BINDING; SHEEP; TISSUE DISTRIBUTION;

AMIDES; ANESTHETICS, INHALATION; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUG INTERACTIONS; FEMALE; HALOTHANE; INFUSIONS, INTRAVENOUS; LIDOCAINE; MEPIVACAINE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PRILOCAINE; PROTEIN BINDING; SHEEP; TISSUE DISTRIBUTION;

EID: 42449110876     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31816ba541     Document Type: Article

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