Enantioselectivity of thiopental distribution into the central neural tissue of rats: An interaction with halothane

Anesthesia and Analgesia

Volumn 89, Issue 1, 1999, Pages 230-235

  Mather, Laurence E ^a   Edwards, Stephen R ^a   Duke, Colin C ^a   Cousins, Michael J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE; THIOPENTAL;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG TISSUE LEVEL; DRUG UPTAKE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NERVOUS TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE;

ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; BRAIN; DRUG INTERACTIONS; HALOTHANE; MALE; RATS; RATS, WISTAR; SPINAL CORD; STEREOISOMERISM; THIOPENTAL;

EID: 0033014939     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199907000-00042     Document Type: Article

References (23)

1. Christensen HD, Lee IS. Anaesthetic potency and acute toxicity of optically active disubstituted barbituric acids. Toxicol Appl Pharmacol 1973;26:495-503.
2. Haley TJ, Gidley JT. Pharmacological comparison of R(+), S(-) and racemic thiopentone in mice. Eur J Pharmacol 1976;36: 211-4.
3. Huang JL, Mather LE, Duke CC. High-performance liquid chromatographic determination of thiopentone enantiomers in sheep plasma. J Chromatogr B Biomed Appl 1995;673:245-50.
4. Cordato DJ, Gross AS, Herkes GK, Mather LE. Pharmacokinetics of thiopentone enantiomers following intravenous injection or prolonged infusion of rac-thiopentone. Br J Clin Pharmacol 1997;43:355-62.
5. Mather LE, Upton RN, Huang JL, et al. The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis. J Pharmacol Exp Ther 1996;279:291-7.
6. Nguyen KT, Stephens DP, McLeish MJ, et al. Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental. Anesth Analg 1996;83: 552-8.
7. Gustafsson LL, Ebling WF, Osaki E, et al. Plasma concentration clamping in the rat using a computer-controlled infusion pump. Pharm Res 1992;9:800-7.
8. Schwilden H, Schüttler J, Stoekel H. Pharmacokinetics as applied to total intravenous anaesthesia: theoretical considerations. Anaesthesia 1983;38(Suppl):51-2.
9. Runciman WB, Myburgh J, Upton RN, Mather LE. Effects of anaesthesia on drug disposition. In: Feldman SA, Scurr CF, Paton W, eds. Mechanisms of action of drugs in anaesthetic practice. 2nd ed. London: Edward Arnold, 1993:83-128.
10. Wada RD, Harashima H, Ebling WF, et al. Effects of thiopental on regional blood flows in the rat. Anesthesiology 1996;84: 596-604.
11. Fragen RJ. Cardiovascular effects of intravenous anesthetics. In: Altura BM, Halevy JD, eds. Cardiovascular actions of anesthetics and drugs used in anesthesia. Vol 1. Basel: Karger, 1986: 51-69.
12. Runciman WB, Mather LE, Selby DG. Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. Br J Anaesth 1990;65:353-9.
13. Mather LE, Selby DG, Runciman WB. The effects of propofol and of thiopentone anaesthesia on the elimination of pethidine in the sheep. Br J Anaesth 1990;65:365-72.
14. Turcant A, Delhumeau A, Premel-Cabic A, et al. Thiopental pharmacokinetics under conditions of long-term infusion. Anesthesiology 1985;63:50-4.
15. Buch U, Altmayer P, Isenberg J, Buch HP. Increase of thiopental concentration in tissues of the rat due to an anesthesia with halothane. Arzneimittelforschung 1991;41:363-6.
16. Hoffman WE. Influence of anesthetics on regional blood flow. In: Altura BM, Halevy JD, eds. Cardiovascular actions of anesthetics and drugs used in anesthesia. Vol 2. Basel: Karger, 1986: 5-34.
17. Mather LE, Runciman WB, Ilsley AH. Anesthesia-induced changes in regional blood flow: implications for drug disposition. Reg Anesth 1982;79:S23-33.
18. Buch U, Altmayer P, Isenberg J, Buch HP. Increased binding of thiopental in tissue homogenates of the rat in the presence of a volatile anesthetic. Arzneimittelforschung 1991;41:696-8.
19. Büch U, Isenberg JC, Baldauf J, et al. Uptake and effects of thiopental in isolated heart preparations of the rat in the presence of halothane. Arzneimittelforschung 1993;43:1-5.
20. Büch U, Altmayer P, Isenberg J, Buch HP. Increase of thiopental concentration in rat tissues due to an anesthesia with isoflurane. Methods Find Exp Clin Pharmacol 1991;13:687-91.
21. Archer DP, Ewen A, Roth SH, Samanani N. Plasma, brain, and spinal cord concentrations of thiopental associated with hyperalgesia in the rat. Anesthesiology 1994;80:168-76.
22. Young WL, Ornstein E. Cerebral and spinal cord blood flow. In: Cottrell JE, Smith DS, eds. Anesthesia and neurosurgery. St. Louis, MO: Mosby, 1994:17-58.
23. Nyström B, Norlen K. Regional spinal cord and brain blood flows in the rat. Neurol Res 1983;5:91-101.