Challenges in discovering bioactives for the food industry

Current Opinion in Biotechnology

Volumn 19, Issue 2, 2008, Pages 66-72

  Schwager, Joseph ^a   Mohajeri, M Hasan ^a   Fowler, Ann ^a   Weber, Peter ^a  

^a DSM Nutritional Products ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; MEDICAL PROBLEMS; METABOLISM; NUTRITION;

BIOACTIVE FOOD INGREDIENTS; FOOD INDUSTRY;

FOOD PRODUCTS;

NUTRACEUTICAL;

FOOD CHAIN; FOOD COMPOSITION; FOOD INDUSTRY; INFORMATION PROCESSING; NUTRITIONAL SCREENING; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SCREENING;

DIETARY SUPPLEMENTS; FOOD INDUSTRY; HUMANS; LEGISLATION, FOOD; MODELS, THEORETICAL; NUTRITION PHYSIOLOGY;

EID: 42449085290     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2008.02.016     Document Type: Review

References (26)

1. Heinrich M, Prieto JM: Diet and healthy ageing 2100: Will we globalise local knowledge systems? Ageing Res Rev 2007:published on line.
2. Weber P., Flühmann B., and Eggersdorfer M. In: Heinrich M., Müller W., and Galli C. (Eds). Development of Bioactive Substances for Foods to Improve Heath - Scientific and Other Aspects vol. 59 (2006), Karger, Basel
3. Fowler A., Seifert N., Acker V., Woehrle T., Kilpert C., and de Saizieu A. A nonradioactive high-throughput/high-content assay for measurement of the human serotonin reuptake transporter function in vitro. J Biomol Screen 11 (2006) 1027-1034. One of the first papers illustrating the usefulness of screening pure natural compounds and related plant extracts.
4. Grande S., Bogani P., de Saizieu A., Schueler G., Galli C., and Visioli F. Vasomodulating potential of Mediterranean wild plant extracts. J Agric Food Chem 52 (2004) 5021-5026
5. Pereira D.A., and Williams J.A. Origin and evolution of high throughput screening. Br J Pharmacol 152 (2007) 53-61. This is a review describing the rationale and principals that shaped the platform of HTS in pharmaceutical research.
6. Offord-Cavin E, Williamson G, Courtois D, Lemaure B, Touche A, Soon G, Ameye L: Nutritional compositions for promotion of bone growth and maintenance of bone health and methods regarding same. US Patent 2007. This is a recent example of the implementation of a systematic screening approach in nutritional sciences and its relevance for patent applications.
7. Lee S., and Howell B.J. High-content screening: emerging hardware and software technologies. Methods Enzymol 414 (2006) 468-483
8. Pepperkok R., and Ellenberg J. High-throughput fluorescence microscopy for systems biology. Nat Rev Mol Cell Biol 7 (2006) 690-696
9. Rines D.R., Tu B., Miraglia L., Welch G.L., Zhang J., Hull M.V., Orth A.P., and Chanda S.K. High-content screening of functional genomic libraries. Methods Enzymol 414 (2006) 530-565
10. Vaisberg E., Lenzi D., Hansen R., Keon B., and Finer J. An infrastructure for high-throughput microscopy: instrumentation, informatics, and integration. Methods Enzymol 414 (2006) 484-512
11. Davidov E., Holland J., Marple E., and Naylor S. Advancing drug discovery through systems biology. Drug Discov Today 8 (2003) 175-183
12. Uetz P., Giot L., Cagney G., Mansfield T.A., Judson R.S., Knight J.R., Lockshon D., Narayan V., Srinivasan M., Pochart P., et al. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403 (2000) 623-627
13. Sonnenburg E.D., Sonnenburg J.L., Manchester J.K., Hansen E.E., Chiang H.C., and Gordon J.I. A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism. Proc Natl Acad Sci U S A 103 (2006) 8834-8839
14. Starkuviene V., and Pepperkok R. The potential of high-content high-throughput microscopy in drug discovery. Br J Pharmacol 152 (2007) 62-71. This is a comprehensive review describing the technical and scientific principles of automated high-content high-throughput fluorescence microscopy at a large scale and its potential application for the discovery process.
15. Nakanishi J., Takarada T., Yunoki S., Kikuchi Y., and Maeda M. FRET-based monitoring of conformational change of the beta2 adrenergic receptor in living cells. Biochem Biophys Res Commun 343 (2006) 1191-1196. This article demonstrates a method for monitoring the agonist-induced conformational change of β2 adrenergic receptor in living cells based on fluorescence resonance energy transfer (FRET) technology.
16. Meyer B.H., Martinez K.L., Segura J.M., Pascoal P., Hovius R., George N., Johnsson K., and Vogel H. Covalent labeling of cell-surface proteins for in-vivo FRET studies. FEBS Lett 580 (2006) 1654-1658
17. Phizicky E., Bastiaens P.I., Zhu H., Snyder M., and Fields S. Protein analysis on a proteomic scale. Nature 422 (2003) 208-215
18. Besenicar M., Macek P., Lakey J.H., and Anderluh G. Surface plasmon resonance in protein-membrane interactions. Chem Phys Lipids 141 (2006) 169-178
19. Unfricht D.W., Colpitts S.L., Fernandez S.M., and Lynes M.A. Grating-coupled surface plasmon resonance: a cell and protein microarray platform. Proteomics 5 (2005) 4432-4442
20. Lee S., Paran Y., Lavelin I., Naffar-Abu-Amara S., Winograd-Katz S., Liron Y., and Geiger B. Development and application of automatic high-resolution light microscopy for cell-based screens. Methods Enzymol 414 (2006) 228-247
21. Loging W., Harland L., and Williams-Jones B. High-throughput electronic biology: mining information for drug discovery. Nat Rev Drug Discov 6 (2007) 220-230. This is an elegant work providing insight into advances of computational or in silico techniques for HTS drug discovery.
22. Ekins S., Mestres J., and Testa B. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br J Pharmacol 152 (2007) 9-20. This study offers an insightful overview of the rationale behind some of the in silico methods for pharmacology that are used for virtual ligand screening and virtual affinity profiling. The authors also describe some examples of successful ligand screening efforts and discuss some of the advantages and disadvantages of in silico methods with respect to in vitro and in vivo methods for pharmacology research.
23. Tanaka M., Bateman R., Rauh D., Vaisberg E., Ramachandani S., Zhang C., Hansen K.C., Burlingame A.L., Trautman J.K., Shokat K.M., et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol 3 (2005) e128
24. Perlman Z.E., Mitchison T.J., and Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem 6 (2005) 145-151
25. Kiger A.A., Baum B., Jones S., Jones M.R., Coulson A., Echeverri C., and Perrimon N. A functional genomic analysis of cell morphology using RNA interference. J Biol 2 (2003) 27
26. Gavin A.C., Aloy P., Grandi P., Krause R., Boesche M., Marzioch M., Rau C., Jensen L.J., Bastuck S., Dumpelfeld B., et al. Proteome survey reveals modularity of the yeast cell machinery. Nature 440 (2006) 631-636