Molecular epidemiology of Plasmodium falciparum infections among asymptomatic inhabitants of a holoendemic malarious area in northern Ghana

Tropical Medicine and International Health

Volumn 7, Issue 5, 2002, Pages 421-428

  Owusu Agyei, S ^a   Smith, Thomas ^a   Beck, H P ^a   Amenga Etego, L ^a   Felger, I ^a  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

All ages; Ghana; msp2 gene; Multiplicity of infection; PCR RFLP; Plasmodium falciparum

Indexed keywords

AGE; DISEASE PREVALENCE; HEALTH MONITORING; MALARIA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION FUNCTION; ENDEMIC DISEASE; FEMALE; FEVER; GENOTYPE; GHANA; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MICROSCOPY; NEWBORN; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CHILD; CHILD WELFARE; CHILD, PRESCHOOL; DATA COLLECTION; ENDEMIC DISEASES; FEMALE; GHANA; HUMANS; INFANT; INFANT WELFARE; INFANT, NEWBORN; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RURAL HEALTH; SENSITIVITY AND SPECIFICITY;

GHANA;

PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE; PLASMODIUM VIVAX;

EID: 0036091009     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2002.00881.x     Document Type: Article

References (37)

1. Species composition and inversion polymorphism of the Anopheles gambiae complex in some sites of Ghana, west Africa
2. Unstable malaria in Sudan: The influence of the dry season. Clone multiplicity of Plasmodium falciparum infections in individuals exposed to variable levels of disease transmission
3. Unstable malaria in Sudan: The influence of the dry season. Plasmodium falciparum population in the unstable malaria area of eastern Sudan is stable and genetically complex
4. Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania
5. Seasonal malaria attack rates in infants and young children in northern Ghana
6. Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66
7. Patterns of malaria morbidity and mortality in children in northern Ghana
8. Assessing population dynamics in a rural African society: The Navrongo Demographic Surveillance System
9. Incidence of Plasmodium falciparum infection in infants in relation to exposure to sporozoite-infected anophelines
10. Different genetic characteristics of Plasmodium falciparum isolates collected during successive clinical malaria episodes in Senegalese children
11. The epidemiology of multiple-clone Plasmodium falciparum infection in The Gambia
12. Analysis of Plasmodium falciparum infections in a village community in Northern Nigeria: Determination of msp2 genotypes and parasite-specific IgG responses
13. Genotyping of Plasmodium falciparum infections by PCR: A comparative multicentre study
14. Plasmodium falciparum: Extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea
15. Genotypes of merozoite surface protein 2 of Plasmodium falciparum in Tanzania
16. Estimation of numbers of malaria clones in blood samples
17. Population structure of recrudescent Plasmodium falciparum isolates from western Uganda
18. Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions
19. Limited spatial clustering of individual Plasmodium falciparum alleles in field isolates from coastal Kenya
20. Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast
21. Predicting outcome in malaria: Correlation between rate of exposure to infected mosquitoes and level of Plasmodium falciparum parasitaemia
22. Prospective risk of morbidity in relation to multiplicity of infection with Plasmodium falciparum, Sao Tome
23. Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections
24. Plasmodium falciparum: Sickle-cell trait is associated with higher prevalence of multiple infections in Gabonese children with asymptomatic infections
25. Novel Plasmodium falciparum clones and rising clone multiplicities are associated with the increase in malaria morbidity in Ghanaian children during the transition into the high transmission season
26. Incidence of symptomatic and asymptomatic Plasmodium falciparum infection following curative therapy in adult residents of northern Ghana
27. Genetic diversity of Plasmodium falciparum and its relationship to parasite density in an area with different malaria endemicities in West Uganda
28. Detection of very low level Plasmodium falciparum infections using the nested polymerase chain reaction and a reassessment of the epidemiology of unstable malaria in Sudan
29. A point mutation in codon 76 of pfcrt of Plasmodium falciparum is positively selected for by chloroquine treatment in Tanzania
30. Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity
31. Premunition in Plasmodium falciparum infection: Insights from the epidemiology of multiple infections
32. Dynamics of multiple Plasmodium falciparum infections in infants in a highly endemic area of Tanzania
33. Rapid evaluation of malaria parasite density and standardization of thick smear examination for epidemiological investigations
34. The Dielmo project: A longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal
35. Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: A prospective community study
36. No influence of age on infection complexity and allelic distribution in Plasmodium falciparum infections in Ndiop, a Senegalese village with seasonal, mesoendemic malaria