Fusion of circulating blood cells with solid-organ tissue cells in clinical stem cell transplants: A potential therapeutic model?

Regenerative Medicine

Volumn 3, Issue 2, 2008, Pages 157-164

  Körbling, Martin ^a   de Lima, Marcos J ^a   Thomas, Elizabeth ^a   Khanna, Abha ^a   Najjar, Amer M ^a   Gu, Jun ^a   Gelovani, Juri G ^a   Broaddus, Russell ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

BCR ABL fusion gene; Cell to cell fusion; Circulating stem cells; Endometrial cells; Hematopoietic stem cell transplantation

Indexed keywords

BCR ABL PROTEIN; BUSULFAN; CELL MARKER; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ESTROGEN RECEPTOR; IMATINIB; METHOTREXATE; VINCRISTINE;

ADULT; APPENDICITIS; ARTICLE; BLAST CELL CRISIS; BLOOD CELL; CASE REPORT; CELL FUSION; CENTRAL NERVOUS SYSTEM METASTASIS; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA TRANSFER; DRUG MEGADOSE; ENDOMETRIUM CELL; ENGRAFTMENT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HETEROZYGOTE; HLA MATCHING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKEMIA RELAPSE; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; TARGET CELL; Y CHROMOSOME;

ADULT; CELL FUSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; STEM CELL TRANSPLANTATION;

EID: 42349113563     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460751.3.2.157     Document Type: Article

References (25)

1. Körbling M, Estrov Z. Adult stem cells for tissue repair - a new therapeutic concept? N. Engl. J. Med. 349, 570-582 (2003).
2. Lagasse E, Connors H, Al-Dhalimy M et al.: Purified hematopoletic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6, 1229-1234 (2000).
3. Kondo T, Raff M: Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754-1757 (2000).
4. Wang X, Willenbring H, Akkari Y et al.: Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422, 897-901 (2003).
5. Körbling M, Katz RL, Khanna A et al.: Hepatocytes and epithelial cells of donor origin in recipients of peripheral blood stem cells. N. Engl. J. Med. 346, 738-746, (2002).
6. Vassilopoulos G, Wang PR, Russell DW: Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901-904 (2003).
7. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM et al.: Fusion of bone-marrow-derived cells with Purjinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973 (2003).
8. Harris RG, Herzog FL, Bruscia EM, Grove JE, van Arnam JS, Krause DS: Lack of fusion requirement for development of bone marrow-derived epithelia. Science 305, 90-93 (2004).
9. Cowan CA, Atienza J, Melton DA, Eggan K: Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309, 1369-1373 (2005).
10. Terada N, Hamazaki T, Oka M et al.: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416, 542-545 (2002).
11. ying QL, Nichols J, Evans EP, Smith AG: Changing potency by spontaneous fusion. Nature 416, 545-548 (2002).
12. Do JT, Schwer HR. Cell-cell fusion as a means to establish pluripotency. Ernst Schering Res. Found. Workshop 35-45 (2006).
13. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC: Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428, 668-673 (2004).
14. Murry CE, Soonpaa H, Reinecke H et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial tnfarcts. Nature 428, 664-668 (2004).
15. Willenbring H, Grompe M: Delineating the hepatocyte's hematopoietic fusion partner. Cell Cycle 3, 1489-1491 (2004).
16. Chen EH, Grote E, Mohler W, Vignery A; Cell-cell fusion. FEBS Lett. 581, 2181-2193 (2007).
17. Willenbring H, Bailey AS, Foster M et al.: Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med. 10, 744-748 (2004).
18. Camargo FD, Finegold M, Goodell MA: Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J. Clin. Invest. 113, 1266-1270 (2004).
19. Doyonnas R, LaBarge MA, Sacco A, Charlton C, Blau HM: Hematopoietic contribution of skeletal muscle regeneration by myelomonocytic precursors. Proc. Natl Acad. Sci. USA 101, 13507-13512 (2004).
20. Prockop DJ, Gregory CA, Spees JL: One strategy for cell and gene therapy: harnessing the power of adult stem cells to repairtissues. Proc. Natl Acad. Sci. USA 100(Suppl.1), 11917-11923 (2003).
21. Sullivan S, Eggan K. The potential of cell fusion for human therapy. Stem Cell Rev. 2, 341-349 (2006).
22. Herzog EL, Krause DS: Engraftment of marrow-derived epithelial cells. Proc. Am. Thorac. Soc. 3, 691-695 (2006).
23. Weimann JM, Charlton CA, Brazelton TR, Hackman RC, Blau HM: Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Natl Acad. Sci. USA 100, 2088-2093 (2003).
24. Srivatsa B, Srivatsa S, Johnson KL, Samura O, Lee SL, Bianchi DW. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. Lancet 358, 2034-2038 (2001).
25. Jamieson CH, Ailles LE, Dylla SJ et al.: Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N. Engl. J. Med.fs 351, 657-667 (2004).