Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5742-5755

  Li, Xingnan ^a   Vince, Robert ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

HIV integrase inhibitor; Metal chelating ligand; Pd catalyzed amidation; Purine

Indexed keywords

INTEGRASE INHIBITOR; METAL CHELATE; PURINE DERIVATIVE;

AMIDATION; ANTIVIRAL ACTIVITY; ARTICLE; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

AMIDES; CATALYSIS; CHELATING AGENTS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; KETO ACIDS; MAGNESIUM; METALS; PALLADIUM; PICOLINIC ACIDS; PURINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745736446     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.011     Document Type: Article

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