Comparative evaluation of absorption, distribution, and excretion of YM758, a novel If channel inhibitor, between albino and non-albino rats

Xenobiotica

Volumn 38, Issue 5, 2008, Pages 527-539

  Umehara, K I ^a   Seya, K ^b   Sonoda, T ^a   Nakamura, E ^a   Noguchi, K ^a   Usui, T ^a   Kamimura, H ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b SEKISUI CHEMICAL CO LTD   (Japan)

Author keywords

Absorption; Distribution; Metabolism and excretion; Pharmacokinetics; Rat; YM758

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; N [2,3 [(6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBONYL)PIPERIDINO]ETHYL] 4 FLUOROBENZAMIDE PHOSPHATE; UNCLASSIFIED DRUG; YM 758;

ALBINO RAT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANNULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG URINE LEVEL; EYEBALL; GASTROINTESTINAL ABSORPTION; HEART ATRIUM FIBRILLATION; MALE; NONHUMAN; RADIOACTIVITY; RAT; RAT STRAIN; SINGLE DRUG DOSE; SPECIES COMPARISON; STABLE ANGINA PECTORIS; THORACIC AORTA; TISSUE DISTRIBUTION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZAMIDES; ENTEROHEPATIC CIRCULATION; HEART RATE; INTESTINAL ABSORPTION; ISOQUINOLINES; MALE; RATS; RATS, INBRED F344; RATS, LONG-EVANS; SINOATRIAL NODE; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

ANGINA; RATTUS;

EID: 42249089874     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250801995788     Document Type: Article

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