The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-κB

Oncogene

Volumn 27, Issue 18, 2008, Pages 2648-2655

  Loveridge, C J ^a   MacDonald, A D H ^a   Thoms, H C ^a   Dunlop, M G ^a   Stark, L A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Aspirin; Cell adhesion; Cell death; Chemoprevention; Colon cancer; Nucleolus

Indexed keywords

ACETYLSALICYLIC ACID; I KAPPA B ALPHA; INDOMETACIN; SULINDAC; SULINDAC SULFONE; TRANSCRIPTION FACTOR RELA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CELL LINE, TUMOR; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYCLOOXYGENASE INHIBITORS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOMETHACIN; SULINDAC; TRANSCRIPTION FACTOR RELA;

EID: 42249089519     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210891     Document Type: Article

References (19)

1. Brandli D, Sarkissian WE, Ng SC, Paulus HE. (1991). Individual variability in concentrations of urinary sulindac sulfide. Clin Pharmacol Ther 50: 650-655.
2. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K et al. (2005). Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 352: 1092-1102.
3. Campbell KJ, Rocha S, Perkins ND. (2004). Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13: 853-865.
4. Din FV, Dunlop MG, Stark LA. (2004). Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. Br J Cancer 91: 381-388.
5. Dippold W, Wittig B, Schwaeble W, Mayet W, Meyer zum Buschenfelde KH. (1993). Expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in colonic epithelial cells. Gut 34: 1593-1597.
6. Dutta J, Fan Y, Gupta N, Fan G, Gelinas C. (2006). Current insights into the regulation of programmed cell death by NF-kappa B. Oncogene 25: 6800-6816.
7. Gardner SH, Hawcroft G, Hull MA. (2004). Effect of nonsteroidal anti-inflammatory drugs on beta-catenin protein levels and catenin-related transcription in human colorectal cancer cells. Br J Cancer 91: 153-163.
8. Grau MV, Rees JR, Baron JA. (2006). Chemoprevention in gastrointestinal cancers: current status. Basic Clin Pharmacol Toxicol 98: 281-287.
9. Hoffmann A, Natoli G, Ghosh G. (2006). Transcriptional regulation via the NF-kappa B signaling module. Oncogene 25: 6706-6716.
10. Ledebur HC, Parks TP. (1995). Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers. J Biol Chem 270: 933-943.
11. Perkins ND. (2004). NF-kappa B: tumor promoter or suppressor? Trends Cell Biol 14: 64-69.
12. Smith M, Hawcroft G, Hull MA. (2000). The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells. Evidence of different mechanisms of action. Eur J Cancer 36: 664-674.
13. Stark LA, Din FVN, Zwacka RM, Dunlop MG. (2001). Aspirin-induced activation of the NF-κB signalling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. FASEB J 7: 1273-1275, and 10.1096/fj.00-0529fje, 2002.
14. Stark LA, Dunlop MG. (2005). Nucleolar sequestration of RelA (p65) regulates NF-kappa B-driven transcription and apoptosis. Mol Cell Biol 25: 5985-6004.
15. Stark LA, Reid K, Sansom OJ, Din FV, Guichard S, Mayer I et al. (2007). Aspirin activates the NF-kappa B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28: 968-976.
16. Sun Y, Sinicrope FA. (2005). Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol Cancer Ther 4: 51-59.
17. Thoms HC, Dunlop MG, Stark LA. (2007). p38-Mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells. Cancer Res 67: 1660-1669.
18. Vainer B, Horn T, Nielsen OH. (2006). Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: a comparative study of inflammatory bowel disease and colonic neoplasms. Scand J Gastroenterol 41: 318-325.
19. Wolfe MM, Lichtenstein DR, Singh G. (1999). Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340: 1888-1899.