Evaluation of the clearance characteristics of liposomes in the human nose by gamma-scintigraphy

Iranian Journal of Pharmaceutical Research

Volumn 4, Issue 1, 2005, Pages 3-11

  Jaafari, Mahmoud Reza ^a,b   Tafaghodi, Mohsen ^a,c   Sajadi Tabassi, Sayyed Abolghassem ^a,c  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gamma scintigraphy; Liposomes; Mucociliary clearance; Nasal delivery

Indexed keywords

EID: 42149195443     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/IJPR.2010.610     Document Type: Article

References (33)

1. Soane RJ, Frier M, Perkins AC, Jones NS, Davis SS and Illum L. Evaluation of the clearance characteristics of bioadhesive systems in humans. Int. J. Pharm. (1999) 178: 55-65
2. Alpar HO, Bowen JC and Brown MRW. Effectiveness of liposomes as adjuvant of orally and nasally administered tetanus toxoid. Int. J. Pharm. (1992) 88: 335-344
3. Eppstein DA, Byars NE and Allison AC. New adjuvants for vaccines containing purified protein antigens. Adv. Drug Del. Rev. (1990) 4: 233-253
4. Kim CK and Jeong EJ. Development of dried liposomes as effective immuno-adjuvant for hepatitis B surface antigen. Int. J. Pharm. (1995) 115: 193-199
5. Ashan F, Rivas IP, Khan MA and Torres Suarez AI. Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages. J. Control. Rel. (2002) 79: 29-40
6. Nakanishi T, Kunisawa J, Hayashi A, Tsutsumi Y, Kubo K, Nakagawa S, Nakanishi M, Tanaka K and Mayumi T. Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins. J. Control. Rel. (1999) 61: 233-340
7. Vyas SP, Goswami SK and Singh R. Liposomes based nasal delivery system of nifedipine: Development and characterization. Int. J. Pharm. (1995) 118: 23-30
8. Kono K, Iwamoto M, Nishikawa R, Yanagie H and Takagishi T. Design of fusogenic liposomes using a poly (ethylene glycol) derivative having amino groups. J. Control. Rel. (2000) 68: 225-235
9. Newman SP and Wilding IR. Gamma scintigraphy: an in vivo technique for assessing the equivalence of inhaled products. Int. J. Pharm. (1998) 170: 1–9
10. Billa N, Yuen KH, Abdul Khader MA and Omar A. Gamma-scintigraphic study of the gastrointestinal transit and in vivo dissolution of a controlled release diclofenac sodium formulation in xanthan gum matrices. Int. J. Pharm. (2000) 201: 109–120
11. Saari M, Vidgren MT, Koskinen MO, Turjanmaa VM and Nieminen MM. Pulmonary distribution and clearance of two beclomethasone liposome formulations in healthy volunteers. Int. J. Pharm. (1999) 181: 1–9
12. Ugwoke MI, Sam E, Van Den Mooter G, Verbeke N and Kinget R. Nasal mucoadhesive delivery systems of the anti-Parkinsonian drug, apomorphine: influence of drug loading on in vitro and in vivo release in rabbits. Int. J. Pharm. (1999) 181: 125-138
13. Soane RJ, Hinchcliffe M, Davis SS, Illum L. Clearance characteristics of chitosan based formulations in the sheep nasal cavity. Int. J. Pharm. (2001) 217: 183– 191
14. Tafaghodi M, Sajadi Tabassi SA, Jaafari MR, Zakavi SR, Momen Nejad M. Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy. Int. J. Pharm. (2004) 280: 125-135
15. Richardson JL, Whetstone J, Fisher AN, Watts P, Farraj NF, Hinchcliffe M, Benedetti l and Illum L. Gamma-scintigraphy as a novel method to study the distribution and retention of a bioadhesive vaginal delivery system in sheep. J. Control. Rel. (1996) 42: 133-142
16. Meseguer G, Gurny R and Buri P. In vivo evaluation of dosage forms: application of gamma scintigraphy to nonenteral routes of administration. J. Drug Target. (1994) 2: 269–288
17. Gregoriadis G, da Silva H and Florence AT. A procedure for the efficient entrapment of drugs in dehydration-rehydration liposomes (DRVs). Int. J. Pharm. (1990) 65: 235-242.
18. Eyles JE, Williamson ED, Alpar HO. Immunological responses to nasal delivery of free and encapsulated tetanus toxoid: studies on the effect of vehicle volume. Int. J. Pharm. (1999) 189: 75-79
19. Alpar HO, Almeida AJ, Brown MR. Microsphere absorption by the nasal mucosa of the rat. J. Drug Target. (1994) 2: 147-149
20. Stuart BO. Deposition and clearance of inhaled particles. Environ. Health Perspec. (1984) 55: 369-390
21. Payne JM, Sansom BF, Garner RJ, Thomson AR, Miles BJ. Uptake of small resin particles (1-5 microns diameter) by the alimentary canal of the calf. Nature (1960) 188: 586-587
22. Schipper NGM, Verhoef JC and Merkus FWHM. The nasal mucociliary clearance: Relevance to nasal drug delivery. Pharm. Res. (1991) 8: 807-814
23. Farr SJ, Kellaway IW, Parry-Jones DR and Woolfrey SG. 99m-Technetium as a marker of liposomal deposition and clearance in the human lung. Int. J. Pharm. (1985) 26: 303–316
24. 99mTc-DTPA in the human respiratory tract. Int. J. Pharm. (1994) 102: 159–165
25. Vidgren M, Waldrep JC, Arppe J, Black M, Rodarte JA, Cole W and Knight V. A study of 99mtechnetium labelled beclomethasone dipropionate dilauroylphosp hatidylcholine liposome aerosol in normal volunteers. Int. J. Pharm. (1995) 115: 209–216
26. Hardy JG, Lee SW and Wilson CG. Intranasal drug delivery by spray and drops. J. Pharm. Pharmacol. (1985) 37: 294-297
27. Aoki FI and Crawley JCW. Distribution and removal of human serum albumin-technetium-99m instilled intranasally. Br. J. Clin. Pharmacol. (1976) 3: 869-878
28. Suman JD, Laube BL and Dalby R. Comparison of nasal deposition and clearance of aerosol generated by nebulizer and an aqueous spray pump. Pharm. Res. (1999) 16: 1648–1652
29. Illum L, Jorgensen H, Bisgaard H, Krogsgaard O and Rossing N. Bioadhesive microspheres as a potential nasal drug delivery system. Int. J. Pharm. (1987) 39: 189-199
30. Ugwoke MI, Agu RU, Vanbilloen H, Baetens J, Augustijns P, Verbeke N, Mortelmans L, Verbruggen A, Kinget R and Bormans G. Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcellulose. J. Control. Rel. (2000) 68: 207-214
31. Harris AS, Nilsson IM, Wagener ZG and Alkner U. Intranasal administration of peptides: nasal deposition, biological response and absorption of desmopressin. J. Pharm. Sci. (1986) 75: 1085–1088.
32. Vidgren P, Vidgren M, Vainio P, Nuutinen J and Paronen P. Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres. Int. J. Pharm. (1991) 73: 131-136
33. Illum L, Farraj NF, Davis SS, Johansen BR and O’Hagan DT. Investigation of the nasal absorption of biosynthetic human growth hormone in sheep-use of a bioadhesive microsphere delivery system. Int. J. Pharm. (1990) 63: 207-211