Development of techniques for the analysis of isoflavones in soy foods and nutraceuticals

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 11, Issue 3, 2008, Pages 242-247

  Dentith, Susan ^a   Lockwood, Brian ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Biological fluids; Chromatography; Immunoassay; Nutraceuticals; Raw materials; Soy isoflavones

Indexed keywords

ISOFLAVONE DERIVATIVE; NUTRACEUTICAL;

BLOOD LEVEL; CAPILLARY ELECTROPHORESIS; CIRCULATION; DIET SUPPLEMENTATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOASSAY; REVIEW; SENSITIVITY ANALYSIS; SOYBEAN;

CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; ELECTROPHORESIS, CAPILLARY; FOOD ANALYSIS; HUMANS; IMMUNOASSAY; ISOFLAVONES; SENSITIVITY AND SPECIFICITY; SOY FOODS; TIME FACTORS;

EID: 42149185630     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3282fa15c9     Document Type: Review

References (24)

1. Cornwell T, Cohick W, Raskin I. Dietary phytoestrogens and health. Phytochemistry 2004; 65:995-1016.
2. Lockwood GB. Nutraceuticals: A balanced view for healthcare professionals. London: Pharmaceutical Press; 2007. 426 pp.
3. Twaddle NC, Churchwell MI, Doerge DR. High-throughput quantification of soy isoflavones in human and rodent blood using liquid chromatography with electrospray mass spectrometry and tandem mass spectrometry detection. J Chromatogr B 2002; 777:139-145.
4. Peng Y, Chu Q, Liu F, Ye J. Determination of isoflavones in soy products by capillary electrophoresis with electrochemical detection. Food Chem 2004; 87:135-139.
5. Thomas BF, Zeisel SH, Busby MG, et al. Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B 2001; 760:191-205.
6. Oomah BD. Phytoestrogens. In: Hurst WJ, editor. Methods of analysis for functional foods and nutraceuticals. Boca Raton, Florida: CRC Press LLC; 2002, 1-63.
7. Grynkiewicz G, Ksycinska H, Ramza J, Zagrodzka J. Chromatographic quantification of isoflavones (Why and how). Acta Chromatographica 2005; 15:31-65.
8. Morandi S, D'Agostina A, Ferrario F, Arnoldi A. Isoflavone content of Italian soy food products and daily intakes of some specific classes of consumers. Eur Food Res Technol 2005; 221:84-91.
9. Wilkinson AP, Wahala K, Williamson G. Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids. J Chromatogr B 2002; 777:93-109.
10. Hsieh HC, Kao TH, Chen BH. A fast HPLC method for analysis of isoflavones in soybean. J Liquid Chromatogr Relat Technol 2004; 27:315-324.
11. Preinerstorfer B, Sontag G. Determination of isoflavones in commercial soy products by HPLC and coulometric electrode array detection. Eur Food Res Technol 2004; 219:305-310.
12. Rostagno MA, Palma M, Barroso CG. Fast analysis of soy isoflavones by high-performance liquid chromatography with monolithic columns. Anal Chim Acta 2007; 582:243-249. HPLC using monolithic columns was shown to separate 12 isoflavones in 10 min.
13. Wang J, Sporns P. MALDI-TOF MS analysis of isoflavones in soy products. J Agric Food Chem 2000; 48:5887-5892.
14. Setchell KDR, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol: a clue to the effectiveness of soy and its isoflavones. J Nutr 2002; 132:3577-3584.
15. Moors S, Blaszkewicz M, Bolt HM, Degen GH. Simultaneous determination of daidzein, equol, genistein and bisphenol A in human urine by a fast and simple method using SPE and GC-MS. Mol Nutr Food Res 2007; 51:787-798. Large study of isoflavonoids and their metabolism in human urine using SPE and GC-MS.
16. Yuan J-P, Wang J-H, Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora - implications for health. Mol Nutr Food Res 2007; 51:765-781. An excellent review of the studies on metabolism of soy isoflavonoids to equol by human intestinal flora, reviewing the diversity of equol production and its pharmacological activities.
17. Talbot DCS, Ogborne RM, Dadd T, et al. Monoclonal antibody-based time-resolved fluorescence immunoassays for daidzein, genistein, and equol in blood and urine: application to the isoheart intervention study. Clin Chem (Washington) 2007; 53:748-756. An immunoassay technique for studying isoflavonoid metabolism in blood and urine.
18. Maubach J, Bracke ME, Heyerick A, et al. Quantitation of soy-derived phytoestrogens in human breast tissue and biological fluids by high-performance liquid chromatography. J Chromatogr B 2003; 784:137-144.
19. Wang X-L, Kim H-J, Kang S-I, et al. Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteria. Arch Microbiol 2007; 187:155-160. HPLC with UV detection was used to separate the metabolites of daidzein after incubation with mixed cultures of Eggerthella sp. and Lactobacillus sp.
20. Possemiers S, Bolca S, Eeckhaut E, et al. Metabolism of isoflavones, lignans and prenylflavonoids by intestinal bacteria: producer phenotyping and relation with intestinal community. FEMS Microbiol Ecol 2007; 61:372-383. HPLC with UV detection was used to identify metabolites of soy isoflavones after incubation with faeces from 100 individuals.
21. Setchell KDR, Clerici C, Lephart ED, et al. S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005; 81:1072-1079.
22. Williams LD, Twaddle NC, Churchwell MI, Doerge DR. Quantification of tamoxifen and metabolites and soy isoflavones in human plasma using liquid chromatography with electrospray ionization tandem mass spectrometry. J AOAC Int 2006; 89:1168-1173.
23. Grace PB, Mistry NS, Carter MH, et al. High throughput quantification of phytoestrogens in human urine and serum using liquid chromatography/ tandem mass spectrometry (LC-MS/MS). J Chromatogr B 2007; 853:138-146. State-of-the art LC-MS/MS quantification of isoflavonoids and their metabolites in urine and plasma.
24. Locati D, Morandi S, Cupisti A, et al. Characterization and quantification of soy isoflavone metabolites in serum of renal transplanted patients by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2005; 19:3473-3481.