Comparative regional haemodynamic effects of the nitric oxide synthase inhibitors, S-methyl-L-thiocitrulline and L-NAME, in conscious rats

British Journal of Pharmacology

Volumn 139, Issue 6, 2003, Pages 1235-1243

  Wakefield, Ian D ^a   March, Julie E ^a   Kemp, Philip A ^a   Valentin, Jean Pierre ^b   Bennett, Terence ^a   Gardiner, Sheila M ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Endothelial NOS; Neuronal NOS; Nitric oxide synthase (NOS) inhibitors; Regional haemodynamics; S methyl L thiocitrulline

Indexed keywords

ACETYLCHOLINE; BRADYKININ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; S METHYLTHIOCITRULLINE; SALBUTAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; DRUG SELECTIVITY; ENZYME INHIBITION; HEMODYNAMICS; KIDNEY BLOOD VESSEL; LEG BLOOD VESSEL; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD VESSEL; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; TACHYCARDIA; VASOCONSTRICTION; VASODILATATION;

ANIMALS; CITRULLINE; CONSCIOUSNESS; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; THIOUREA; VASOCONSTRICTION;

EID: 0041667898     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705351     Document Type: Article

References (46)

1. AISAKA, K., GROSS, S.S., GRIFFITH, O.W. & LEVI, R. (1989). L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo. Biochem. Biophys. Res. Commun., 163, 710-717.
2. ALDERTON, W.K., COOPER, C.E. & KNOWLES, R.G. (2001). Nitric oxide synthases: structure, function and inhibition. Biochem. J., 357, 593-615.
3. CHOATE, J.K., DANSON, E.J.F., MORRIS, J.F. & PATERSON, D.J. (2001). Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice. Am. J. Physiol., 281, H2310-H2317.
4. DAVISSON, R.L., JOHNSON, A.K. & LEWIS, S.J. (1994). In-vivo evidence that preformed stores of nitrosyl factors mediate active sympathetic neurogenic hindlimb vasodilation in the rat. Hypertension, 24, 393-393.
5. DAVISSON, R.L., SHAFFER, R.A., JOHNSON, A.K. & LEWIS, S.J. (1996). Stimulation of lumber sympathetic nerves may produce hindlimb vasodilatation via the release of pre-formed stores of nitrosyl factors. Neuroscience, 72, 881-887.
6. ESPLUGUES, J.V. (2002). NO as a signalling molecule in the nervous system. Br. J. Pharmacol., 135, 1079-1095.
7. ESTRADA, C., MENGUAL, E. & GONZALEZ, C. (1993). Local NADPH diaphorase neurons innervate pial-arteries and lie close or project to intracerebral blood-vessels - a possible role for nitricoxide in the regulation of cerebral bloodflow. J. Cereb. Blood Flow Metab., 13, 978-984.
8. FERRER, M. & BALFAGÓN, G. (2001). Aging alters neuronal oxide release from rat mesenteric arteries: role of presynaptic β-adrenoceptors. Clin. Sci., 101, 321-328.
9. FURFINE, E.S., HARMON, M.F., PAITH, J.E., KNOWLES, R.G., SALTER, M., KIFF, R.J., DUFFY, C., HAZELWOOD, R., OPLINGER, J.A. & GARVEY, E.P. (1994). Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. J. Biol. Chem., 269, 26677-26683.
10. GARDINER, S.M., COMPTON, A.M., BENNETT, T., PALMER, R.M.J. & MONCADA, S. (1990a). Control of regional blood flow by endothelium-derived nitric oxide. Hypertension, 15, 486-492.
11. G-nitro-L-arginine methyl ester in conscious, Long Evans rats. Br. J. Pharmacol., 101, 625-631.
12. G-nitro-L-arginine methyl ester or indomethacin on differential regional and cardiac haemodynamic actions of arginine vasopressin and lysine vasopressin in conscious rats. Br. J. Pharmacol., 102, 65-72.
13. G-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N-ethylcarboxyamidoadenosine or salbutamol in conscious rats. Br. J. Pharmacol., 103, 1725-1732.
14. GARDINER, S.M., KEMP, P.A. & BENNETT, T. (1993). Effects of chronic treatment with nitric oxide synthase inhibitors on regional haemodynamic responses to vasodilators in conscious Brattleboro rats. Br. J. Pharmacol., 109, 222-228.
15. 2-adrenoceptors in the regional haemodynamic responses to bradykinin in conscious rats. Br. J. Pharmacol., 105, 839-848.
16. GARDINER, S.M., MARCH, J.E., KEMP, P.A. & BENNETT, T. (1998). The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen-2) 27) rats. Br. J. Pharmacol., 124, 299-306.
17. GOZAL, D., TORRES, J.E., GOZAL, Y.M. & LITTWIN, S.M. (1996). Effect of nitric oxide synthase inhibition on cardio-respiratory responses in the conscious rat. J. Appl. Physiol., 81, 2068-2077.
18. GRAY, D.W. & MARSHALL, I. (1992). Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta. Br. J. Pharmacol., 107, 684-690.
19. ICHIHARA, A., INSCHO, E.W., IMIG, J.D. & NAVAR, L.G. (1998). Neuronal nitric oxide synthase modulates rat renal microvascular function. Am. J. Physiol., 274, F5I6-F524.
20. JUMRUSSIRIKUL, P., DINERMAN, J., DAWSON, T.M., DAWSON, V.L., EKELUND, U., GEORGAKOPOULOS, D., SCHRAMM, L.P., CALKINS, H., SNYDER, S.H., HARE, J.M. & BERGER, R.D. (1998). Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. J. Clin. Invest., 102, 1279-1285.
21. KAKOKI, M., ZOU, A-P. & MATTSON, D.L. (2001). The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am. J. Physiol., 281, R91-R97.
22. KOMERS, R., OYAMA, T.T., CHAPMAN, J.G, ALLISON, K.M. & ANDERSON, S. (2000). Effects of systemic inhibition of neuronal nitric oxide synthase in diabetic rats. Hypertension, 35, 655-661.
23. KURIHARA, N., ALFIE, M.E., SIGMON, D.H., RHALEB. N-R., SHESELY, E.G. & CARRETERO, O.A. (1998). Role of nNOS on blood pressure regulation in eNOS null mutant mice. Hypertension, 32, 856-861.
24. MARIN, J. & BALFAGÓN, G. (1998). Effect of clenbuterol on non-endothelial nitric oxide release in rat mesenteric arteries and the involvement of beta-adrenoceptors. Br. J. Pharmacol., 124, 473-478.
25. MONCADA, S., REES, D.D., SCHULZ, R. & PALMER, R.M.J. (1991). Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. U.S.A., 88, 2166-2170.
26. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.
27. MOORE, P.K., WALLACE, P., GAFFEN, Z., HART, S.L. & BABBEDGE, R.C. (1993). Characteristics of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br. J. Pharmacol., 110, 219-224.
28. NARAYANAN, K., SPACK, L., MCMILLAN, K., KILBOURN, R.G., HAYWARD, M.A., MASTERS, B.S.S. & GRIFFITH, O.W. (1995). S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. J. Biol. Chem., 270, 11103-11110.
29. OLLERSTAM, A., PITTNER, J., PERSSON, A.E.G. & THORUP, C. (1997). Increased blood pressure in rats after long-term inhibition of the neuronal isoform of nitric oxide synthase. J. Clin. Invest., 99, 2212-2218.
30. PALMER, R.M.J., REES, D.D., ASHTON, D.S. & MONCADA, S. (1988). L-arginine is the physiological precursor for the formation of nitricoxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun., 153, 1251-1256.
31. PARKINGTON, H.C., TARE, M., TONTA, M.A. & COLEMAN, H.A. (1993). Stretch revealed 3 components in the hyperpolarization of guinea-pig coronary-artery in response to acetylcholine. J. Physiol., 465, 459-476.
32. PFEIFFER, S., LEOPOLD, E., SCHMIDT, K., BRUNNER, F. & MAYER, B. (1996). Inhibition of nitric oxide synthesis by N-G-nitro-L-arginine methyl ester (L-NAME): Requirement for bioactivation to the free acid, N-G-nitro-L-arginine. Br. J. Pharmacol., 118, 1433-1440.
33. RANDALL, M.D., ALEXANDER, S.P.H., BENNETT, T., BOYD, E.A., FRY, J.R., GARDINER, S.M., KEMP, P.A., MCCULLOCH, A.I. & KENDALL, D.A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem. Biophys. Res. Commun., 229, 114-120.
34. REES, D.D., PALMER, R.M.J., SCHULZ, R., HODSON, H.F. & MONCADA, S. (1990). Characterization of 3 inhibitors of endothelial nitric-oxide synthase in vitro and in vivo. Br. J. Pharmacol., 101, 746-752.
35. RUBANYI, G. & VANHOUTTE, P.M. (1985). Endothelium removal decreases relaxations of canine coronary arteries caused by beta-adrenergic agonists and adenosine. J. Cardiovasc. Pharmacol., 7, 139-144.
36. THEODORSSON-NORHEIM, E. (1987). Friedman and Quade tests: BASIC computer program to perform nonparametric two-way analysis of variance and multiple comparisons on ranks of several related samples. Comput. Biol. Med., 17, 85-99.
37. TODA, N. & OKAMURA, T. (1992). Mechanism of neurally induced monkey mesenteric-artery relaxation and contraction. Hypertension, 19, 161-166.
38. TODA, N. & OKAMURA, T. (1996). Nitroxidergic nerve: regulation of vascular tone and blood flow in the brain. J. Hypertens., 14, 423-434.
39. VANHOUTTE, P.M. & LEVY, M.N. (1980). Prejunctional cholinergic modulation of adrenergic neurotransmission in the cardiovascular system. Am. J. Physiol., 238, H275-H281.
40. VAUPEL, D.B., KIMES, A.S. & LONDON, E.D. (1997). Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy. Eur. J. Pharmacol., 324, 11-20.
41. WAKEFIELD, I.D., GARDINER, S.M., VALENTIN, J-P. & BENNETT, T. (2002a). Regional haemodynamic effects of the nitric oxide synthase inhibitor S-methyl-L-thiocitrulline in conscious Sprague Dawley rats. Br. J. Pharmacol., 135, 136P.
42. WAKEFIELD, I.D., GARDINER, S.M., VALENTIN, J-P. & BENNETT, T. (2002b). Effects of the nitric oxide synthase inhibitor, S-methyl-L-thiocitrulline (SMTC), on the regional haemodynamic responses to acetylcholine in conscious Sprague Dawley rats. Br. J. Pharmacol., 135, 296P.
43. G-nitro-L-arginine methyl ester (L-NAME) on salbutamol-induced hindquarters vasodilatation in conscious rats. Br. J. Pharmacol., 137, 58P.
44. G-nitro-L-arginine methyl ester in conscious Long Evans rats. Br. J. Pharmacol., 105, 653-656.
45. WILCOX, C.S., DENG, X. & WELCH, W.J. (1998). NO generation and action during changes in salt intake: roles of nNOS and macula densa. Am. J. Physiol., 274, R1588-R1593.
46. ZAGVAZDIN, Y., SANCESARIO, G., WANG, Y-X., SHARE, L., FITZGERALD, M.E.C. & REINER, A. (1996). Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo. Eur. J. Pharmacol., 303, 61-69.