메뉴 건너뛰기




Volumn 20, Issue 4, 2008, Pages 519-528

Leptin inhibits basal but not gonadotrophin-stimulated testosterone production in the immature mouse and sheep testis

Author keywords

Postnatal development

Indexed keywords

GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE; TESTOSTERONE;

EID: 42149151009     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD07062     Document Type: Article
Times cited : (18)

References (39)
  • 1
    • 0343852115 scopus 로고    scopus 로고
    • Effect of short-term testosterone treatment on leptin concentrations in boys with pubertal delay
    • doi:10.1159/000023445
    • Adan, L., Bussieres, L., Trivin, C., Souberbielle, J. C., and Brauner, R. (1999). Effect of short-term testosterone treatment on leptin concentrations in boys with pubertal delay. Horm. Res. 52, 109-112. doi:10.1159/000023445
    • (1999) Horm. Res , vol.52 , pp. 109-112
    • Adan, L.1    Bussieres, L.2    Trivin, C.3    Souberbielle, J.C.4    Brauner, R.5
  • 3
    • 0032032575 scopus 로고    scopus 로고
    • Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function
    • doi:10.1172/JCI1176
    • Ahima, R. S., Prabakaran, D., and Flier, J. S. (1998). Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J. Clin. Invest. 101, 1020-1027. doi:10.1172/JCI1176
    • (1998) J. Clin. Invest , vol.101 , pp. 1020-1027
    • Ahima, R.S.1    Prabakaran, D.2    Flier, J.S.3
  • 4
    • 0007854317 scopus 로고    scopus 로고
    • Changes in the testis interstitium of Sprague Dawley rats from birth to sexual maturity
    • doi:10.1095/BIOLREPROD62.3.680
    • Ariyaratne, H. B., and Chamindrani Mendis-Handagama, S. (2000). Changes in the testis interstitium of Sprague Dawley rats from birth to sexual maturity. Biol. Reprod. 62, 680-690. doi:10.1095/BIOLREPROD62.3.680
    • (2000) Biol. Reprod , vol.62 , pp. 680-690
    • Ariyaratne, H.B.1    Chamindrani Mendis-Handagama, S.2
  • 5
    • 0033087599 scopus 로고    scopus 로고
    • Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development
    • doi:10.1046/J.1432-1327.1999.00245.X
    • Baker, P. J., Sha, J. A., McBride, M. W., Peng, L., Payne, A. H., and O'Shaughnessy, P. J. (1999). Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development. Eur. J. Biochem. 260, 911-917. doi:10.1046/J.1432-1327.1999.00245.X
    • (1999) Eur. J. Biochem , vol.260 , pp. 911-917
    • Baker, P.J.1    Sha, J.A.2    McBride, M.W.3    Peng, L.4    Payne, A.H.5    O'Shaughnessy, P.J.6
  • 7
    • 0020742070 scopus 로고
    • Changes in testicular gonadotropin receptors and steroid content through postnatal development until puberty in the lamb
    • Barenton, B., Hochereau-de Reviers, M. T., Perreau, C., and Saumande, J. (1983). Changes in testicular gonadotropin receptors and steroid content through postnatal development until puberty in the lamb. Endocrinology 112, 1447-1453.
    • (1983) Endocrinology , vol.112 , pp. 1447-1453
    • Barenton, B.1    Hochereau-de Reviers, M.T.2    Perreau, C.3    Saumande, J.4
  • 8
    • 0034435919 scopus 로고    scopus 로고
    • Decrease in voluntary feed intake and pulsatile luteinizing hormone secretion after intracerebroventricular infusion of recombinant bovine leptin in mature male sheep
    • doi:10.1071/RD00102
    • Blache, D., Celi, P., Blackberrv, M. A., Dynes, R. A., and Martin, G. B. (2000a). Decrease in voluntary feed intake and pulsatile luteinizing hormone secretion after intracerebroventricular infusion of recombinant bovine leptin in mature male sheep. Reprod. Fertil. Dev. 12, 373-381. doi:10.1071/RD00102
    • (2000) Reprod. Fertil. Dev , vol.12 , pp. 373-381
    • Blache, D.1    Celi, P.2    Blackberrv, M.A.3    Dynes, R.A.4    Martin, G.B.5
  • 9
    • 0034046348 scopus 로고    scopus 로고
    • Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep
    • doi:10.1677/JOE.0.1650625
    • Blache, D., Tellam, R. L., Chagas, L. M., Blackberry, M. A., Vercoe, P. E., and Martin, G. B. (2000b). Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep. J. Endocrinol. 165, 625-637. doi:10.1677/JOE.0.1650625
    • (2000) J. Endocrinol , vol.165 , pp. 625-637
    • Blache, D.1    Tellam, R.L.2    Chagas, L.M.3    Blackberry, M.A.4    Vercoe, P.E.5    Martin, G.B.6
  • 10
    • 0035450519 scopus 로고    scopus 로고
    • Expression of Connexin43 in mouse Leydig, sertoli, and germinal cells at different stages of postnatal development
    • doi:10.1002/AR.1100
    • Bravo-Moreno, J. F., Díaz-Sánchez, V., Montoya-Flores, J. G., Lamoyi, E., Saéz, J. C., and Pérez-Armendariz, E. M. (2001). Expression of Connexin43 in mouse Leydig, sertoli, and germinal cells at different stages of postnatal development. Anat. Rec. 264, 13-24. doi:10.1002/AR.1100
    • (2001) Anat. Rec , vol.264 , pp. 13-24
    • Bravo-Moreno, J.F.1    Díaz-Sánchez, V.2    Montoya-Flores, J.G.3    Lamoyi, E.4    Saéz, J.C.5    Pérez-Armendariz, E.M.6
  • 11
    • 0034751338 scopus 로고    scopus 로고
    • Puberty in female mice is not associated with increases in either body fat or leptin
    • doi:10.1210/EN.142.11.4758
    • Bronson, F. H. (2001). Puberty in female mice is not associated with increases in either body fat or leptin. Endocrinology 142, 4758-4761. doi:10.1210/EN.142.11.4758
    • (2001) Endocrinology , vol.142 , pp. 4758-4761
    • Bronson, F.H.1
  • 12
    • 0037378624 scopus 로고    scopus 로고
    • Ontogenesis of leptin receptor in rat leydig cells
    • doi:10.1095/BIOLREPROD.102.007831
    • Caprio, M., Fabbrini, E., Ricci, G., Basciani, S., Gnessi, L., et al. (2003). Ontogenesis of leptin receptor in rat leydig cells. Biol. Reprod. 68, 1199-1207. doi:10.1095/BIOLREPROD.102.007831
    • (2003) Biol. Reprod , vol.68 , pp. 1199-1207
    • Caprio, M.1    Fabbrini, E.2    Ricci, G.3    Basciani, S.4    Gnessi, L.5
  • 13
    • 0020673218 scopus 로고
    • Maturation of the hypothalamic-pituitary-gonadal axis in the male lamb: A review
    • doi:10.1016/0306- 4530(83)90058-6
    • Collu, R., Savoie, S., Hamel, R., Gibb, W., and Ducharme, J. R. (1983). Maturation of the hypothalamic-pituitary-gonadal axis in the male lamb: a review. Psychoneuroendocrinology 8, 213-224. doi:10.1016/0306- 4530(83)90058-6
    • (1983) Psychoneuroendocrinology , vol.8 , pp. 213-224
    • Collu, R.1    Savoie, S.2    Hamel, R.3    Gibb, W.4    Ducharme, J.R.5
  • 14
    • 0031559755 scopus 로고    scopus 로고
    • Developmental changes in ob gene expression and circulating leptin peptide concentrations
    • doi:10.1006/BBRC.1997.7237
    • Devaskar, S. U., Ollesch, C., Rajakumar, R. A., and Rajakumar, P. A. (1997). Developmental changes in ob gene expression and circulating leptin peptide concentrations. Biochem. Biophys. Res. Commun. 238, 44-47. doi:10.1006/BBRC.1997.7237
    • (1997) Biochem. Biophys. Res. Commun , vol.238 , pp. 44-47
    • Devaskar, S.U.1    Ollesch, C.2    Rajakumar, R.A.3    Rajakumar, P.A.4
  • 15
    • 0034061509 scopus 로고    scopus 로고
    • The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men
    • doi:10.1046/J.1365-2265.2000.00965.X
    • Erfurth, E. M., and Ahren, B. (2000). The negative association between serum free testosterone and leptin is dependent on insulin-like growth factor-binding protein 1 in healthy young and middle-aged men. Clin. Endocrinol. 52, 493-498. doi:10.1046/J.1365-2265.2000.00965.X
    • (2000) Clin. Endocrinol , vol.52 , pp. 493-498
    • Erfurth, E.M.1    Ahren, B.2
  • 16
    • 0033304579 scopus 로고    scopus 로고
    • Spermatogenesis without gonadotropins: Maintenance has a lower testosterone threshold than initiation
    • doi:10.1210/EN.140.9.3938
    • Handelsman, D. J., Spaliviero, J. A., Simpson, J. M., Allan, C. M., and Singh, J. (1999). Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation. Endocrinology 140, 3938-3946. doi:10.1210/EN.140.9.3938
    • (1999) Endocrinology , vol.140 , pp. 3938-3946
    • Handelsman, D.J.1    Spaliviero, J.A.2    Simpson, J.M.3    Allan, C.M.4    Singh, J.5
  • 17
    • 0023606858 scopus 로고
    • The heterogeneity of isolated adult rat Leydig cells sperated on Percoll density gradients: An immunological, cytochemical and functional analysis
    • Hedger, M. P., and Eddy, E. M. (1987). The heterogeneity of isolated adult rat Leydig cells sperated on Percoll density gradients: an immunological, cytochemical and functional analysis. Endocrinology 121, 1824-1838.
    • (1987) Endocrinology , vol.121 , pp. 1824-1838
    • Hedger, M.P.1    Eddy, E.M.2
  • 18
    • 33747666200 scopus 로고    scopus 로고
    • Leptin has concentration and stage-dependent effects on embryonic development in vitro
    • doi:10.1530/REP.1.01083
    • Herrid, M., Nguyen, V. L., Hinch, G., and McFarlane, J. R. (2006). Leptin has concentration and stage-dependent effects on embryonic development in vitro. Reproduction 132, 247-256. doi:10.1530/REP.1.01083
    • (2006) Reproduction , vol.132 , pp. 247-256
    • Herrid, M.1    Nguyen, V.L.2    Hinch, G.3    McFarlane, J.R.4
  • 19
    • 0033304558 scopus 로고    scopus 로고
    • Leptin and androgens in male obesity: Evidence for leptin contribution to reduced androgen levels
    • doi:10.1210/JC.84.10.3673
    • Isidori, A. M., Caprio, M., Strollo, F., Moretti, C., Frajese, G., Isidori, A., and Fabbri, A. (1999). Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J. Clin. Endocrinol. Metab. 84, 3673-3680. doi:10.1210/JC.84.10.3673
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 3673-3680
    • Isidori, A.M.1    Caprio, M.2    Strollo, F.3    Moretti, C.4    Frajese, G.5    Isidori, A.6    Fabbri, A.7
  • 21
    • 0033921678 scopus 로고    scopus 로고
    • Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: Development and characterisation of an ovine leptin ELISA
    • doi:10.1677/JOE.0.1660127
    • Kauter, K., Ball, M., Kearney, P., Tellam, R., and McFarlane, J. R. (2000). Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. J. Endocrinol. 166, 127-135. doi:10.1677/JOE.0.1660127
    • (2000) J. Endocrinol , vol.166 , pp. 127-135
    • Kauter, K.1    Ball, M.2    Kearney, P.3    Tellam, R.4    McFarlane, J.R.5
  • 22
    • 0021925264 scopus 로고
    • Morphological and functional characterization of interstitial cells from mouse testes fractionated on Percoll density gradients
    • Kerr, J. B., Robertson, D. M., and de Kretser, D. M. (1985). Morphological and functional characterization of interstitial cells from mouse testes fractionated on Percoll density gradients. Endocrinology 116, 1030-1043.
    • (1985) Endocrinology , vol.116 , pp. 1030-1043
    • Kerr, J.B.1    Robertson, D.M.2    de Kretser, D.M.3
  • 23
    • 0023222052 scopus 로고
    • Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure
    • doi:10.1095/BIOLREPROD36.3.769
    • Klinefelter, G. R., and Ewing, L. L. (1987). Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biol. Reprod. 36, 769-783. doi:10.1095/BIOLREPROD36.3.769
    • (1987) Biol. Reprod , vol.36 , pp. 769-783
    • Klinefelter, G.R.1    Ewing, L.L.2
  • 24
    • 0028700822 scopus 로고
    • Stimulatory and inhibitory factors of Leydig cell steroidogenesis are secreted simultaneously by the rat seminiferous tubules and do not affect Leydig cell inhibin production in vitro
    • doi:10.1071/RD9940693
    • McFarlane, J. R., de Kretser, D. M., and Risbridger, G. P. (1994). Stimulatory and inhibitory factors of Leydig cell steroidogenesis are secreted simultaneously by the rat seminiferous tubules and do not affect Leydig cell inhibin production in vitro. Reprod. Fertil. Dev. 6, 693-698. doi:10.1071/RD9940693
    • (1994) Reprod. Fertil. Dev , vol.6 , pp. 693-698
    • McFarlane, J.R.1    de Kretser, D.M.2    Risbridger, G.P.3
  • 25
    • 0029939232 scopus 로고    scopus 로고
    • Evidence that heparin binding autocrine factors modulate testosterone production by the adult rat Leydig cell
    • doi:10.1016/0303-7207(96)03766-5
    • McFarlane, J. R., Laslett, A., de Kretser, D. M., and Risbridger, G. P. (1996). Evidence that heparin binding autocrine factors modulate testosterone production by the adult rat Leydig cell. Mol. Cell. Endocrinol. 118, 57-63. doi:10.1016/0303-7207(96)03766-5
    • (1996) Mol. Cell. Endocrinol , vol.118 , pp. 57-63
    • McFarlane, J.R.1    Laslett, A.2    de Kretser, D.M.3    Risbridger, G.P.4
  • 26
    • 0035924089 scopus 로고    scopus 로고
    • Developmental regulation of leptin gene expression in rat brain and pituitary
    • doi:10.1016/S0303-7207(01) 00626-8
    • Morash, B., Wilkinson, D., Murphy, P., Ur, E., and Wilkinson, M. (2001). Developmental regulation of leptin gene expression in rat brain and pituitary. Mol. Cell. Endocrinol. 185, 151-159. doi:10.1016/S0303-7207(01) 00626-8
    • (2001) Mol. Cell. Endocrinol , vol.185 , pp. 151-159
    • Morash, B.1    Wilkinson, D.2    Murphy, P.3    Ur, E.4    Wilkinson, M.5
  • 27
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • doi:10.1210/EN.138.3.1190
    • Mounzih, K., Lu, R., and Chehab, F. F. (1997). Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138, 1190-1193. doi:10.1210/EN.138.3.1190
    • (1997) Endocrinology , vol.138 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 28
    • 0033775888 scopus 로고    scopus 로고
    • Gonadal steroids and energy homeostasis in the leptin era
    • doi:10.1016/S0899-9007(00)00458-5
    • Mystkowski, P., and Schwartz, M. W. (2000). Gonadal steroids and energy homeostasis in the leptin era. Nutrition 16, 937-946. doi:10.1016/S0899-9007(00)00458-5
    • (2000) Nutrition , vol.16 , pp. 937-946
    • Mystkowski, P.1    Schwartz, M.W.2
  • 29
    • 85047683605 scopus 로고    scopus 로고
    • Localization of 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis: Androstenedione is the major androgen secreted by fetal/neonatal leydig cells
    • doi:10.1210/EN.141.7. 2631
    • O'Shaughnessy, P. J., Baker, P. J., Heikkila, M., Vainio, S., and McMahon, A. P. (2000). Localization of 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis: androstenedione is the major androgen secreted by fetal/neonatal leydig cells. Endocrinology 141, 2631-2637. doi:10.1210/EN.141.7. 2631
    • (2000) Endocrinology , vol.141 , pp. 2631-2637
    • O'Shaughnessy, P.J.1    Baker, P.J.2    Heikkila, M.3    Vainio, S.4    McMahon, A.P.5
  • 30
    • 0019812458 scopus 로고    scopus 로고
    • Savoie, S., Polychronakos, C., Forest, M. G., Haour, F., Collu, R., and Ducharme, J. R. (1981). Perinatal activity of the hypothalamic-pituitary-gonadal axis in the lamb. III. LH, testosterone and prolactin secretory pattern in newborn lambs. Horm. Res. 15, 167-178.
    • Savoie, S., Polychronakos, C., Forest, M. G., Haour, F., Collu, R., and Ducharme, J. R. (1981). Perinatal activity of the hypothalamic-pituitary-gonadal axis in the lamb. III. LH, testosterone and prolactin secretory pattern in newborn lambs. Horm. Res. 15, 167-178.
  • 31
    • 0028876068 scopus 로고
    • Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    • doi:10.1210/EN.136.12.5311
    • Singh, J., O'Neill, C., and Handelsman, D. J. (1995). Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice. Endocrinology 136, 5311-5321. doi:10.1210/EN.136.12.5311
    • (1995) Endocrinology , vol.136 , pp. 5311-5321
    • Singh, J.1    O'Neill, C.2    Handelsman, D.J.3
  • 32
    • 0021880718 scopus 로고
    • Stage-specific inhibition of interstitial cell testosterone secretion by rat seminiferous tubules in vitro
    • doi:10.1016/0303-7207(85)90181-9
    • Syed, V., Khan, S. A., and Ritzen, E. M. (1985). Stage-specific inhibition of interstitial cell testosterone secretion by rat seminiferous tubules in vitro. Mol. Cell. Endocrinol. 40, 257-264. doi:10.1016/0303-7207(85)90181-9
    • (1985) Mol. Cell. Endocrinol , vol.40 , pp. 257-264
    • Syed, V.1    Khan, S.A.2    Ritzen, E.M.3
  • 33
    • 0032982948 scopus 로고    scopus 로고
    • Leptin inhibits testosterone secretion from adult rat testis in vitro
    • doi:10.1677/JOE.0.1610211
    • Tena-Sempere, M., Pinilla, L., Gonzalez, L. C., Dieguez, C., Casanueva, F. F., and Aguilar, E. (1999). Leptin inhibits testosterone secretion from adult rat testis in vitro. J. Endocrinol. 161, 211-218. doi:10.1677/JOE.0.1610211
    • (1999) J. Endocrinol , vol.161 , pp. 211-218
    • Tena-Sempere, M.1    Pinilla, L.2    Gonzalez, L.C.3    Dieguez, C.4    Casanueva, F.F.5    Aguilar, E.6
  • 34
    • 42149161541 scopus 로고    scopus 로고
    • Valenti, S., Cesarone, A., Foppiani, L., Giordano, G., and Giusti, M. (1998). Effect of recombinat murine leptin administration on percoll-purified rat Leydig cells (Abstract). In 'IV European Congress of Endocrinology'. pp. OR5-6. (BioScientifica: Bristol.)
    • Valenti, S., Cesarone, A., Foppiani, L., Giordano, G., and Giusti, M. (1998). Effect of recombinat murine leptin administration on percoll-purified rat Leydig cells (Abstract). In 'IV European Congress of Endocrinology'. pp. OR5-6. (BioScientifica: Bristol.)
  • 35
    • 0025884678 scopus 로고
    • Proliferative activity of gonocytes, sertoli cells and interstitial cells during testicular development in mice
    • Vergouwen, R. P., Jacobs, S. G., Huiskamp, R., Davids, J. A., and de Rooij, D. G. (1991). Proliferative activity of gonocytes, sertoli cells and interstitial cells during testicular development in mice. J. Reprod. Fertil. 93, 233-243.
    • (1991) J. Reprod. Fertil , vol.93 , pp. 233-243
    • Vergouwen, R.P.1    Jacobs, S.G.2    Huiskamp, R.3    Davids, J.A.4    de Rooij, D.G.5
  • 36
    • 0034456450 scopus 로고    scopus 로고
    • Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men
    • doi:10.1210/JC.85.8.2839
    • Wang, C., Swerdloff, R. S., Iranmanesh, A., Dobs, A., Snyder, P. J., Cunningham, G., Matsumoto, A. M., Weber, T., and Berman, N. (2000). Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J. Clin. Endocrinol. Metab. 85, 2839-2853. doi:10.1210/JC.85.8.2839
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 2839-2853
    • Wang, C.1    Swerdloff, R.S.2    Iranmanesh, A.3    Dobs, A.4    Snyder, P.J.5    Cunningham, G.6    Matsumoto, A.M.7    Weber, T.8    Berman, N.9
  • 37
    • 0031019763 scopus 로고    scopus 로고
    • Role of leptin in hypothalamic-pituitary function
    • doi:10.1073/PNAS.94.3.1023
    • Yu, W. H., Kimura, M., Walczewska, A., Karanth, S., and McCann, S. M. (1997). Role of leptin in hypothalamic-pituitary function. Proc. Natl Acad. Sci. USA 94, 1023-1028. doi:10.1073/PNAS.94.3.1023
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 1023-1028
    • Yu, W.H.1    Kimura, M.2    Walczewska, A.3    Karanth, S.4    McCann, S.M.5
  • 38
    • 0034026809 scopus 로고    scopus 로고
    • Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin
    • Yura, S., Ogawa, Y., Sagawa, N., Masuzaki, H., Itoh, H., Ebihara, K., Aizawa-Abe, M., Fujii, S., and Nakao, K. (2000). Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. J. Clin. Invest. 105, 749-755.
    • (2000) J. Clin. Invest , vol.105 , pp. 749-755
    • Yura, S.1    Ogawa, Y.2    Sagawa, N.3    Masuzaki, H.4    Itoh, H.5    Ebihara, K.6    Aizawa-Abe, M.7    Fujii, S.8    Nakao, K.9
  • 39
    • 0032850991 scopus 로고    scopus 로고
    • Leptin impairs the synergistic stimulation by transforming growth factor-beta of follicle-stimulating hormone-dependent aromatase activity and messenger ribonucleic acid expression in rat ovarian granulosa cells
    • doi:10.1095/BIOLREPROD61.4.1104
    • Zachow, R. J., Weitsman, S. R., and Magoffin, D. A. (1999). Leptin impairs the synergistic stimulation by transforming growth factor-beta of follicle-stimulating hormone-dependent aromatase activity and messenger ribonucleic acid expression in rat ovarian granulosa cells. Biol. Reprod. 61, 1104-1109. doi:10.1095/BIOLREPROD61.4.1104
    • (1999) Biol. Reprod , vol.61 , pp. 1104-1109
    • Zachow, R.J.1    Weitsman, S.R.2    Magoffin, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.