Effect of short-term testosterone treatment on leptin concentrations in boys with pubertal delay

Hormone Research

Volumn 52, Issue 3, 1999, Pages 109-112

  Adan, L ^a   Bussieres L ^a   Trivin, C ^a   Souberbielle, J C ^a   Brauner, R ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Growth factors; Growth hormone; Insulin; Leptin; Puberty, delayed

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN; LEPTIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TESTOSTERONE; TESTOSTERONE ENANTATE;

ADIPOSE TISSUE; ADOLESCENT; ARTICLE; BLOOD LEVEL; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED PUBERTY; GROWTH HORMONE DEFICIENCY; HORMONE RELEASE; HUMAN; MALE; PRIORITY JOURNAL; PROVOCATION TEST; WEIGHT GAIN;

EID: 0343852115     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023445     Document Type: Article

References (17)

1. Mantzoros CS, Flier JS, Rogol AD: A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82: 1066-1070.
2. Garcia-Mayor RV, Andrade AM, Rios M, Lage M, Dieguez C, Casanueva FF: Serum leptin levels in normal children: Relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab 1997;82:2849-2855.
3. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Müller J, Skakkeback NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W: Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82: 2904-2910.
4. Jockenhövel F, Blum WF, Vogel E, Englaro P, Müller-Wirland D, Reiwein D, Rascher W, Krone W: Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 1997;82: 2510-2513.
5. Elbers JMH, Asscheman H, Seidell JC, Frölich M, Meinders AE, Gooren LJG: Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab 1997;82:3267-3270.
6. Luukkaa V, Pesonen U, Huhtaniemi I, Lehtonen A, Tilvis R, Tuomilehto J, Koulu M, Huupponen R: Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab 1998;83:3243-3246.
7. Adan L, Souberbielle JC, Brauner R: Management of the short stature due to pubertal delay in boys. J Clin Endocrinol Metab 1994;78:478-482.
8. Rolland-Cachera MF, Cole TJ, Sempé M, Tichet J, Rossignol C, Charraud A: Body mass index variations: Centiles from birth to 87 years. Eur J Clin Nutr 1991;45:13-21.
9. Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:13-23.
10. Burr IM, Sizonenko PC, Kaplan SL, Grumbach MM: Hormonal changes during puberty. I. Correlation of serum luteinizing hormone and follicle-stimulating hormone with stages of puberty, testicular size, and bone age in normal boys. Pediatr Res 1970;4:25-35.
11. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100:808-813.
12. Palmert MR, Radovick S, Boepple PA: The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab 1998;83:1091-1096.
13. Arslanian S, Suprasongsin C: Testosterone treatment in adolescents with delayed puberty: Changes in body composition, protein, fat, and glucose metabolism. J Clin Endocrinol Metab 1997;82:3213-3220.
14. Mauras N, Hayes N, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD, Urban RJ: Testosterone deficiency in young men: Marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab 1998; 83:1886-1892.
15. Miyakawa M, Tsushima T, Murakami H, Isozaki O, Demura H, Tanaka T: Effect of growth hormone (GH) on serum concentrations of leptin: Study in patients with acromegaly and GH deficiency. J Clin Endocrinol Metab 1998;83: 3476-3479.
16. Rauch F, Westermann F, Englaro P, Blum WF, Schönau E: Serum leptin is suppressed by growth hormone therapy in growth hormone-deficient children. Horm Res 1998;50:18-21.
17. Kriström B, Carlsson B, Rosberg S, Carlsson MS, Albertsson-Wikland K, on behalf of the Swedish Study Group for Growth Hormone Treatment: Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children. J Clin Endocrinol Metab 1998;83:2735-2741.