Melatonin, consciousness, and traumatic stress

Journal of Pineal Research

Volumn 44, Issue 4, 2008, Pages 341-347

  Bob, Petr ^a   Fedor Freybergh, Peter ^a,b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b St Elisabeth University College   (Slovakia)

Author keywords

Consciousness; Dissociation; Melatonin; Memory; Pineal gland; Stress

Indexed keywords

MELATONIN;

CIRCADIAN RHYTHM; COGNITION; CONSCIOUSNESS; HORMONAL REGULATION; HUMAN; MEMORY; MENTAL STRESS; NEUROPSYCHOLOGY; NEUROSECRETORY CELL; PINEAL BODY; PSYCHOTRAUMA; SHORT SURVEY; SPATIAL MEMORY; STRESS;

ANIMALS; CEREBRAL CORTEX; CIRCADIAN RHYTHM; CONSCIOUSNESS; GENE EXPRESSION REGULATION; HUMANS; LONG-TERM POTENTIATION; MELATONIN; MEMORY; MENTAL DISORDERS; NEURONS; PINEAL GLAND; STRESS; SUPRACHIASMATIC NUCLEUS; WOUNDS AND INJURIES;

EID: 42149132259     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2007.00540.x     Document Type: Short Survey

References (136)

1. Yu HS, Reiter RJ. Melatonin: biosynthesis, physiological effects, and clinical applications. CRC Press, Boca Raton FL 1993.
2. Reiter R, Tan DX, Manchester LC et al. Melatonin in edible plants (Phytomelatonin): identification, concentrations, bioavailability and proposed functions. World Rev Nutr Diet 2007 97 : 211 230.
3. Afreen F, Zobayed SMA, Kozai T. Melatonin in Glycyrrhiza uralensis: response of plant roots to spectral quality of light and UV-B radiation. J Pineal Res 2006 41 : 108 115.
4. Fideleff HL, Boquete H, Fideleff G et al. Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals. J Pineal Res 2006 40 : 214 218.
5. Lerner AB, Case JD, Takahashi Y et al. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 1958 80 : 2587.
6. Cardinali DP, Rosner JM. Metabolism of serotonin by the rat retina 'in vitro'. J Neurochem 1971 18 : 769 1770.
7. Tosini G, Menaker M. The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration. Brain Res 1998 789 : 221 228.
8. Liu C, Fukuhara C, Wessel JH III. et al. Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection. Cell Tissue Res 2004 315 : 197 201.
9. Conti A, Conconi S, Hertens E et al. Evidence for melatonin synthesis in mouse and human bone marrow cells. J Pineal Res 2000 28 : 193 202.
10. Champier J, Claustrat B, Besancon R et al. Evidence for tryptophan hydroxylase and hydroxyindol-O-methyl-transferase mRNAs in human blood platelets. Life Sci 1997 60 : 2191 2197.
11. Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002 47 : 2336 2348.
12. Slominski A, Wortsman J, Tobin DJ. The cutaneous serotoninergic/ melatoninergic system: securing a place under the sun. FASEB J 2005 19 : 176 194.
13. Slominski A, Fischer TW, Zmijewski MA et al. On the role of melatonin in skin physiology and pathology. Endocrine 2005 27 : 137 148.
14. Carrillo-Vico A, Calvo JR, Abreu P et al. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB J 2004 18 : 537 539.
15. Cardinali DP, Furio AM, Reyes MP et al. The use of chronobiotics in the resynchronization of the sleep-wake cycle. Cancer Causes Control 2006 17 : 601 609.
16. Morin LP. SCN organization reconsidered. J Biol Rhythms 2007 22 : 3 13.
17. Kalsbeek A, Perreau-Lenz S, Buijs RM. A network of (autonomic) clock outputs. Chronobiol Int 2006 23 : 521 535.
18. Rutter J, Reick M, McKnight SL. Metabolism and the control of circadian rhythms. Annu Rev Biochem 2002 71 : 307 331.
19. Messager S, Garabette ML, Hastings MH et al. Tissue-specific abolition of Per1 expression in the pars tuberalis by pinealectomy in the Syrian hamster. Neuroreport 2001 12 : 579 582.
20. Uz T, Akhisaroglu M, Ahmed R et al. The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice. Neuropsychopharmacology 2003 28 : 2117 2123.
21. Von Gall C, Garabette ML, Kell CA et al. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci 2002 5 : 234 238.
22. Perrin JS, Segall LA, Harbour VL et al. The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle. Proc Natl Acad Sci U S A 2006 103 : 5591 5596.
23. Barrera-Mera B, Barrera-Calva E. The Cartesian clock metaphor for pineal gland operation pervades the origin of modern chronobiology. Neurosci Biobehav Rev 1998 23 : 1 4.
24. Smith CU. Descartes' pineal neuropsychology. Brain Cogn 1998 36 : 57 72.
25. Van de Grind W. Physical, neural, and mental timing. Conscious Cogn 2002 11 : 241 264.
26. John ER. The neurophysics of consciousness. Brain Res Brain Res Rev 2002 39 : 1 28.
27. Singer W. Consciousness and the binding problem. Ann N Y Acad Sci 2001 929 : 123 146.
28. Crick F, Koch C. A framework for consciousness. Nat Neurosci 2003 6 : 119 126.
29. Zeman A. Consciousness. Brain 2001 124 (Pt 7) : 1263 1289.
30. Kalsbeek A, Palm IF, La Fleur SE et al. SCN outputs and the hypothalamic balance of life. J Biol Rhythms 2006 21 : 458 469.
31. Indic P, Schwartz WJ, Herzog ED et al. Modeling the behavior of coupled cellular circadian oscillators in the suprachiasmatic nucleus. J Biol Rhythms 2007 22 : 211 219.
32. Hamada T, Antle MC, Silver R. Temporal and spatial expression patterns of canonical clock genes and clock-controlled genes in the suprachiasmatic nucleus. Eur J Neurosci 2004 19 : 1741 1748.
33. Pevet P, Agez L, Bothorel B et al. Melatonin in the multi-oscillatory mammalian circadian world. Chronobiol Int 2006 23 : 39 51.
34. Saper CB, Lu J, Chou TC et al. The hypothalamic integrator for circadian rhythms. Trends Neurosci 2005 28 : 152 157.
35. Baydas G, Ozveren F, Akdemir I et al. Learning and memory deficits in rats induced by chronic thinner exposure are reversed by melatonin. J Pineal Res 2005 39 : 50 56.
36. Larson J, Jessen RE, Uz T et al. Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice. Neurosci Lett 2006 393 : 23 26.
37. Chaudhury D, Wang LM, Colwell CS. Circadian regulation of hippocampal long-term potentiation. J Biol Rhythms 2005 20 : 225 236.
38. Ozcan M, Yilmaz B, Carpenter DO. Effects of melatonin on synaptic transmission and long-term potentiation in two areas of mouse hippocampus. Brain Res 2006 1111 : 90 94.
39. Wang LM, Suthana NA, Chaudhury D et al. Melatonin inhibits hippocampal long-term potentiation. Eur J Neurosci 2005 22 : 2231 2237.
40. Gorfine T, Zisapel N. Melatonin and the human hippocampus, a time dependent interplay. J Pineal Res 2007 43 : 80 86.
41. Saenz DA, Goldin AP, Minces L et al. Effect of melatonin on the retinal glutamate/glutamine cycle in the golden hamster retina. FASEB J 2004 18 : 1912 1913.
42. Skaper SD, Ancona B, Facci L et al. Melatonin prevents the delayed death of hippocampal neurons induced by enhanced excitatory neurotransmission and the nitridergic pathway. FASEB J 1998 12 : 725 731.
43. Shibata S, Cassone VM, Moore RY. Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro. Neurosci Lett 1989 97 : 140 144.
44. Stehle J, Vanecek J, Vollrath L. Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study. J Neural Transm 1989 78 : 173 177.
45. Mason R, Rusak B. Neurophysiological responses to melatonin in the SCN of short-day sensitive and refractory hamsters. Brain Res 1990 533 : 15 19.
46. Jiang ZG, Nelson CS, Allen CN. Melatonin activates an outward current and inhibits Ih in rat suprachiasmatic nucleus neurons. Brain Res 1995 687 : 125 132.
47. Van den Top M, Buijs RM, Ruijter JM et al. Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm. Neuroscience 2001 107 : 99 108.
48. Gerdin MJ, Masana MI, Rivera-Bermudez MA et al. Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. FASEB J 2004 18 : 1646 1656.
49. Zeise ML, Semm P. Melatonin lowers excitability of guinea pig hippocampal neurons in vitro. J Comp Physiol 1985 57 : 23 29.
50. Musshoff U, Riewenherm D, Berger E et al. Melatonin receptors in rat hippocampus: molecular and functional investigations. Hippocampus 2002 12 : 165 173.
51. Wan Q, Man HY, Liu F et al. Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors. Nat Neurosci 1999 2 : 401 403.
52. Hogan MV, El-Sherif Y, Wieraszko A. The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices. J Pineal Res 2001 30 : 87 96.
53. El-Sherif Y, Tesoriero J, Hogan MV et al. Melatonin regulates neuronal plasticity in the hippocampus. J Neurosci Res 2003 72 : 454 460.
54. Bob P. Dissociation and neuroscience: history and new perspectives. Int J Neurosci 2003 113 : 903 914.
55. Bob P. Dissociation, forced normalization and dynamic multistability of the brain. Neuro Endocrinol Lett 2007 28 : 231 246.
56. Spiegel D. Trauma, dissociation, and memory. Ann N Y Acad Sci 1997 821 : 225 237.
57. Kihlstrom JF. Dissociative disorders. Annu Rev Clin Psychol 2005 1 : 227 253.
58. Phillips RG, LeDoux JE. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 1992 106 : 274 285.
59. LeDoux JE. Brain mechanisms of emotion and emotional learning. Curr Opin Neurobiol 1992 2 : 191 198.
60. LeDoux JE. Emotional memory systems in the brain. Behav Brain Res 1993 58 : 69 79.
61. LeDoux JE. Emotion, memory and the brain. Sci Am 1994 270 : 50 57.
62. Bechara A, Tranel D, Damasio H et al. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995 269 : 1115 1118.
63. Diamond DM, Rose GM. Stress impairs LTP and hippocampal-dependent memory. Ann NY Acad Sci 1994 746 : 411 414.
64. Ruel JMHM, De Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985 117 : 2505 2512.
65. Payne JD, Jackson ED, Ryan L et al. The impact of stress on neutral and emotional aspects of episodic memory. Memory 2006 14 : 1 16.
66. Nadel L, Jacobs WJ. Traumatic memory is special. Curr Dir Psychol Sci 1998 7 : 154 157.
67. Kenardy J, Smith A, Spence SH et al. Dissociation in children's trauma narratives: an exploratory investigation. J Anxiety Disord 2007 21 : 456 466.
68. Brewin CR. Autobiographical memory for trauma: update on four controversies. Memory 2007 15 : 227 248.
69. Uysal N, Ozdemir D, Dayi A et al. Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats. Neuro Endocrinol Lett 2005 26 : 555 560.
70. Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine peptides, and other pineal transmitters. Pharmacol Rev 2003 55 : 325 395.
71. Sumaya IC, Masana MI, Dubocovich ML. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res 2005 39 : 170 177.
72. Lepage O, Larson ET, Mayer I et al. Tryptophan affects both gastrointestinal melatonin production and interrenal activity in stressed and nonstressed rainbow trout. J Pineal Res 2005 38 : 264 271.
73. Paredes SD, Sanchez S, Parvez H et al. Altered circadian rhythms of corticosterone, melatonin, and phagocytic activity in response to stress in rats. Neuro Endocrinol Lett 2007 28 : 101 112.
74. Krskova L, Vrabcova M, Zeman M. Effect of melatonin on exploration and anxiety in normotensive and hypertensive rats with high activity of renin-angiotensin system. Neuro Endocrinol Lett 2007 28 : 295 301.
75. Legros C, Chalivoix S, Gabriel C et al. First evidence of melatonin receptors distribution in the suprachiasmatic nucleus of tree shrew brain. Neuro Endocrinol Lett 2007 28 : 267 273.
76. Martinez F, Hernandez T, Sanchez P et al. Synaptic ribbon modifications in the pineal gland of the albino rat following 24 hours of immobilization. Acta Anat 1992 145 : 430 433.
77. Milin J. Stress-reactive response of the gerbil pineal gland: concretion genesis. Gen Comp Endocrinol 1998 110 : 237 251.
78. Milin J, Demajo M, Todorovic V. Rat pinealocyte reactive response to a long-term stress inducement. Neuroscience 1996 73 : 845 854.
79. Lynch HJ, Deng MH. Pineal responses to stress. J Neural Transm Suppl 1986 21 : 461 473.
80. Vollrath L, Welker HA. Day-to-day variation in pineal serotonin N-acetyltransferase activity in stressed and nonstressed male Sprague-Dawley rats. Life Sci 1988 42 : 2223 2229.
81. Dagnino-Subiabre A, Orellana JA, Carmona-Fontaine C et al. Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. J Neurochem 2006 97 : 1279 1287.
82. Fuchs E, Schumacher M. Psychosocial stress affects pineal function in the tree shrew (Tupaia belangeri). Physiol Behav 1990 47 : 713 717.
83. Larson ET, Winberg S, Mayer I et al. Social stress affects circulating melatonin levels in rainbow trout. Gen Comp Endocrinol 2004 136 : 322 327.
84. Jindal RD, Thase ME. Treatment of insomnia associated with clinical depression. Sleep Med Rev 2004 8 : 19 30.
85. Brown R, Kocsis JH, Caroff S et al. Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. Am J Psychiatry 1985 142 : 811 816.
86. Frazer A, Brown R, Kocsis J et al. Patterns of melatonin rhythms in depression. J Neural Transm (Suppl) 1986 21 : 269 290.
87. Pacchierotti C, Iapichino S, Bossini L et al. Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry. Front Neuroendocrinol 2001 22 : 18 32.
88. Warembourg M. Radioautographic study of the rat brain and pituitary after injection of 3H dexamethasone. Cell Tissue Res 1975 161 : 183 191.
89. Sarrieau A, Dussaillant M, Moguilewsky M. Autoradiographic localization of glucocorticosteroid binding sites in rat brain after in vivo injection of [3H]RU 28362. Neurosci Lett 1988 92 : 14 20.
90. Meyer U, Kruhoffer M, Flugge G et al. Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri). Brain Res Mol Brain Res 1998 55 : 243 253.
91. Torres-Farfan C, Richter HG, Rojas-Garcia P et al. mt1 Melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by melatonin. J Clin Endocrinol Metab 2003 88 : 450 458.
92. Sapolsky RM. The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol Psychiatry 2000 48 : 755 765.
93. Laudon M, Hyde JF, Ben-Jonathan N. Ontogeny of prolactin releasing and inhibiting activities in the posterior pituitary of male rats. Neuroendocrinology 1989 50 : 644 649.
94. Boatright JH, Rubim NM, Iuvone PM. Regulation of endogenous dopamine release in amphibian retina by melatonin: the role of GABA. Vis Neurosci 1994 11 : 1013 1018.
95. Hemby SE, Trojanowski JQ, Ginsberg SD. Neuron-specific age-related decreases in dopamine receptor subtype mRNAs. J Comp Neurol 2003 456 : 176 183.
96. Webb SM, Pulg-Domingo M. Role of melatonin in health and disease. Clin Endocrinol 1995 42 : 221 234.
97. Kennedy SH, Kutcher SP, Ralevski E et al. Nocturnal melatonin and 24-h 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder. Psychiatr Res 1996 63 : 219 222.
98. Lieberman H. The effects of melatonin on human mood and performance. Brain Res 1984 323 : 201 207.
99. Little KY, Ranc J, Gilmore J et al. Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression. Psychoneuroendocrinology 1997 22 : 53 62.
100. Rubin RT, Heist EK, McGeoy SS et al. Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Arch Gen Psychiatr 1992 49 : 558 567.
101. Monteleone P, Natale M, La Rocca A et al. Decreased nocturnal secretion of melatonin in drug-free schizophrenics: no change after subchronic treatment with antipsychotics. Neuropsychobiology 1997 36 : 159 163.
102. Sandyk R, Kay SR. Pineal melatonin in schizophrenia: a review and hypothesis. Schizophr Bull 1990 16 : 653 662.
103. Rao ML, Gross G, Strebel B et al. Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia. Biol Psychiatry 1994 35 : 151 163.
104. Sandyk R. The pineal gland and the mode of onset of schizophrenia. Int J Neurosci 1992 67 : 9 17.
105. Monteleone P, Natale M, Fuschino A et al. Disruption of melatonin circadian rhythm in schizophrenia and obsessive-compulsive disorder. Biol Psychiatry 1997 42 (Suppl 1 226 227.
106. Bandelow B, Sengos G, Wedeking D et al. Urinary excretion of cortisol, norepinephrine, testosterone, and melatonin in panic disorder. Pharmacopsychiatry 1997 30 : 113 117.
107. Arendt J, Bhanji S, Francy C et al. Plasma melatonin levels in anorexia nervosa. Br J Psychiatry 1992 161 : 361 364.
108. Kennedy SH. Melatonin disturbances in anorexia nervosa and bulimia nervosa. Int J Eating Disord 1994 16 : 257 265.
109. Monteleone P, Catapano F, Del Buono G et al. Circadian rhythms of melatonin, cortisol and prolactin in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 1994 89 : 411 415.
110. Morera AL, Abreu P. Seasonality of psychopathology and circannual melatonin rhythm. J Pineal Res 2006 41 : 279 283.
111. Teicher M, Andersen SL, Polcari A et al. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 2003 27 : 3 44.
112. Putnam F. Dissociation in Children and Adolescents. A Developmental Perspective. The Guilford Press, London, New York, 1997.
113. Bob P, Susta M, Pavlat J et al. Depression, traumatic dissociation and epileptic-like phenomena. Neuro Endocrinol Lett 2005 26 : 321 325.
114. Bob P, Glaslova K, Susta M et al. Traumatic dissociation, epileptic-like phenomena, and schizophrenia. Neuro Endocrinol Lett 2006 27 : 321 326.
115. Teicher M, Tomoda A, Andersen SL. Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable? Ann N Y Acad Sci 2006 1071 : 313 323.
116. Bremner JD. The relationship between cognitive and brain changes in posttraumatic stress disorder. Ann N Y Acad Sci 2006 1071 : 80 86.
117. Kellner M, Yehuda R. Do panic disorder and posttraumatic stress disorder share a common psychoneuroendocrinology? Psychoneuroendocrinology 1999 24 : 485 504.
118. Newport DJ, Nemeroff CJ. Neurobiology of posttraumatic stress disorder. Curr Opin Neurobiol 2000 10 : 211 218.
119. Mason JW, Wang S, Yehuda R et al. Psychogenic lowering of urinary cortisol levels linked to increased emotional numbing and a shame-depressive syndrome in combat-related posttraumatic stress disorder. Psychosom Med 2001 63 : 387 401.
120. Gavrilovic L, Dronjak S. Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors. Neuro Endocrinol Lett 2005 26 : 515 520.
121. Nakayama Y, Takahashi T, Radford MH. Cortisol levels and prospective and retrospective memory in humans. Neuro Endocrinol Lett 2005 26 : 599 602.
122. Takahashi T, Ikeda K, Ishikawa M et al. Anxiety, reactivity, and social stress-induced cortisol elevation in humans. Neuro Endocrinol Lett 2005 26 : 351 354.
123. Umegaki H, Yamamoto A, Suzuki Y et al. Stimulation of the hippocampal glutamate receptor systems induces stress-like responses. Neuro Endocrinol Lett 2006 27 : 339 343.
124. Read J, Perry BD, Moskowitz A et al. The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model. Psychiatry 2001 64 : 319 345.
125. Esch T, Stefano GB. The neurobiology of love. Neuro Endocrinol Lett 2005 26 : 175 192.
126. Esch T, Stefano GB. Love promotes health. Neuro Endocrinol Lett 2005 26 : 264 267.
127. Stefano GB, Esch T. Love and stress. Neuro Endocrinol Lett 2005 26 : 173 174.
128. Post RM. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J Psychiatr Res 2007 41 : 979 990.
129. Duman RS, Monteggia LM. A neurothrophic model for stress-related mood disorders. Biol Psychiatry 2006 59 : 1116 1127.
130. Benitez-King G. Melatonin as a cytoskeletal modulator: implications for cell physiology and disease. J Pineal Res 2006 40 : 1 9.
131. Wu YH, Swaab DF. The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res 2005 38 : 145 152.
132. Lee EJ, Lee MY, Chen HY et al. Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J Pineal Res 2005 38 : 42 52.
133. Savaskan E, Ayoub MA, Ravid R et al. Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease. J Pineal Res 2005 38 : 10 16.
134. Kaya O, Gokdemir K, Kilic M et al. Melatonin supplementation to rats subjected to acute swimming exercise: its effect on plasma lactate levels and relation with zinc. Neuro Endocrinol Lett 2006 27 : 263 266.
135. Maldonado MD, Murillo-Cabezas F, Terron MP et al. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 2007 42 : 1 11.
136. Tan DX, Manchester LC, Terron MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.