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Volumn 14, Issue 12, 2008, Pages 1812-1822

Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer

Author keywords

Bevacizumab; Cetuximab; Chemotherapy; Colorectal cancer; Elderly patients

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; INTERFERON; IRINOTECAN; LEVAMISOLE; METHOTREXATE; OXALIPLATIN; PLACEBO; RALTITREXED; UFT;

EID: 42149124929     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.1812     Document Type: Review
Times cited : (7)

References (66)
  • 1
    • 33645346222 scopus 로고    scopus 로고
    • Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials
    • Jennens RR, Giles GG, Fox RM. Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials. Intern Med J 2006; 36: 216-220
    • (2006) Intern Med J , vol.36 , pp. 216-220
    • Jennens, R.R.1    Giles, G.G.2    Fox, R.M.3
  • 2
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17: 2412-2418
    • (1999) J Clin Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3    Parikh, B.4    Cunningham, D.5
  • 3
    • 0033843393 scopus 로고    scopus 로고
    • The application of the principles of geriatrics to the management of the older person with cancer
    • Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol 2000; 35: 147-154
    • (2000) Crit Rev Oncol Hematol , vol.35 , pp. 147-154
    • Balducci, L.1    Beghe, C.2
  • 4
    • 0026509066 scopus 로고    scopus 로고
    • Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B, Reynolds CF 3rd. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 1992; 41: 237-248
    • Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B, Reynolds CF 3rd. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 1992; 41: 237-248
  • 12
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio RB, Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989; 16: 215-237
    • (1989) Clin Pharmacokinet , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 14
    • 42149180941 scopus 로고    scopus 로고
    • Beretta G, Bollina R, Cozzi C, Beretta GA, Morabito A & Members of the GOAL-Group of Oncomedical Associates in Lombardy. Should we consider the weekly chemotherapy with fluorouracil + racemic folinic acid a standard treatment for advanced/metastatic carcinoma of digestive tract in elderly patients? Proceedings of the 33rd Annual Meeting of American Society of Clinical Oncology; 1997 May 17-20; Denver, USA. Alexandria: American Society of Clinical Oncology, 1997: 259
    • Beretta G, Bollina R, Cozzi C, Beretta GA, Morabito A & Members of the GOAL-Group of Oncomedical Associates in Lombardy. Should we consider the weekly chemotherapy with fluorouracil + racemic folinic acid a standard treatment for advanced/metastatic carcinoma of digestive tract in elderly patients? Proceedings of the 33rd Annual Meeting of American Society of Clinical Oncology; 1997 May 17-20; Denver, USA. Alexandria: American Society of Clinical Oncology, 1997: 259
  • 18
    • 5544237608 scopus 로고    scopus 로고
    • Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. "Tomudex" Colorectal Cancer Study Group
    • Cunningham D, Zalcberg JR Rath U, Oliver I, van Cutsem E, Svensson C, Seitz JF, Harper P, Kerr D, Perez-Manga G. Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. "Tomudex" Colorectal Cancer Study Group. Ann Oncol 1996; 7: 961-965
    • (1996) Ann Oncol , vol.7 , pp. 961-965
    • Cunningham, D.1    Zalcberg, J.R.2    Rath, U.3    Oliver, I.4    van Cutsem, E.5    Svensson, C.6    Seitz, J.F.7    Harper, P.8    Kerr, D.9    Perez-Manga, G.10
  • 19
    • 34548470595 scopus 로고    scopus 로고
    • Drug-company decision to end cancer trial
    • Drug-company decision to end cancer trial. Lancet 1999; 354: 1045
    • (1999) Lancet , vol.354 , pp. 1045
  • 22
    • 0003331556 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) has a manageable toxicity profile in elderly patients with metastatic colorectal cancer: Final analysis of a multicentre study
    • May 20-23; New Orleans, USA. Alexandria: American Society of Clinical Oncology
    • Facchini T, Genet D, Berdah JF, Nouyrigat P, Dutin JP, Laplaige P, Haguenauer D. Raltitrexed (Tomudex) has a manageable toxicity profile in elderly patients with metastatic colorectal cancer: Final analysis of a multicentre study. Proceedings of the 36th Annual Meeting of American Society of Clinical Oncology; 2000 May 20-23; New Orleans, USA. Alexandria: American Society of Clinical Oncology, 2000: 298a
    • (2000) Proceedings of the 36th Annual Meeting of American Society of Clinical Oncology
    • Facchini, T.1    Genet, D.2    Berdah, J.F.3    Nouyrigat, P.4    Dutin, J.P.5    Laplaige, P.6    Haguenauer, D.7
  • 23
    • 0031060464 scopus 로고    scopus 로고
    • Mechanism-based improvement in the therapeutic selectivity of 5-FU prodrug alone and under conditions of metabolic modulation
    • Rustum YM. Mechanism-based improvement in the therapeutic selectivity of 5-FU prodrug alone and under conditions of metabolic modulation. Oncology 1997; 54 Suppl 1: 7-11
    • (1997) Oncology , vol.54 , Issue.SUPPL. 1 , pp. 7-11
    • Rustum, Y.M.1
  • 24
    • 0031868962 scopus 로고    scopus 로고
    • UFT and leucovorin: A review of its clinical development and therapeutic potential in the oral treatment of cancer
    • Hoff PM, Pazdur R, Benner SE, Canetta R. UFT and leucovorin: a review of its clinical development and therapeutic potential in the oral treatment of cancer. Anticancer Drugs 1998; 9: 479-490
    • (1998) Anticancer Drugs , vol.9 , pp. 479-490
    • Hoff, P.M.1    Pazdur, R.2    Benner, S.E.3    Canetta, R.4
  • 26
    • 0001073793 scopus 로고    scopus 로고
    • Randomized comparative study of ORZEL (oral uraciL/tegafur (UFT)™) plus leucovorin (LV) versus parenteral 5-fluorouracil (5-FU plus LV) in patients with metastatic colorectal cancer
    • May 15-18; Atlanta, USA. Alexandria: American Society of Clinical Oncology
    • Carmichael J, Popiela T, Radstone D, Falk S, Fey M, Oza A, Skovsgaard T, Martin C. Randomized comparative study of ORZEL (oral uraciL/tegafur (UFT)™) plus leucovorin (LV) versus parenteral 5-fluorouracil (5-FU plus LV) in patients with metastatic colorectal cancer. Proceedings of the 35th Annual Meeting of American Society of Clinical Oncology; 1999 May 15-18; Atlanta, USA. Alexandria: American Society of Clinical Oncology, 1999: 264a
    • (1999) Proceedings of the 35th Annual Meeting of American Society of Clinical Oncology
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3    Falk, S.4    Fey, M.5    Oza, A.6    Skovsgaard, T.7    Martin, C.8
  • 29
    • 42149194752 scopus 로고    scopus 로고
    • A phase II study of orzel (UFT+leucovorin) in elderly (≥75 years old) patients with colorectal cancer: Results of ECOG 1299
    • May 13-17; Orlando, USA. Alexandria: American Society of Clinical Oncology, 273s
    • Popa EC, Luo W, Hochster H, Lyman B, Mulcahy M, Beatty P, Benson AB. A phase II study of orzel (UFT+leucovorin) in elderly (≥75 years old) patients with colorectal cancer: results of ECOG 1299. Proceedings of the 41st Annual Meeting of American Society of Clinical Oncology; 2005 May 13-17; Orlando, USA. Alexandria: American Society of Clinical Oncology, 2005: 273s
    • (2005) Proceedings of the 41st Annual Meeting of American Society of Clinical Oncology
    • Popa, E.C.1    Luo, W.2    Hochster, H.3    Lyman, B.4    Mulcahy, M.5    Beatty, P.6    Benson, A.B.7
  • 38
    • 42149194750 scopus 로고    scopus 로고
    • Schaaf LJ, Ichhpurani N, Elfring GL, Wolf D, Rothenberg M, Von Hoff D. Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer. Proceedings of the 33rd Annual Meeting of American Society of Clinical Oncology; 1997 May 17-20; Denver, USA. Alexandria: American Society of Clinical Oncology, 1997: 202a
    • Schaaf LJ, Ichhpurani N, Elfring GL, Wolf D, Rothenberg M, Von Hoff D. Influence of age on the pharmacokinetics of irinotecan (CPT-11) and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), in patients with previously treated colorectal cancer. Proceedings of the 33rd Annual Meeting of American Society of Clinical Oncology; 1997 May 17-20; Denver, USA. Alexandria: American Society of Clinical Oncology, 1997: 202a
  • 39
    • 42149180940 scopus 로고    scopus 로고
    • Elderly patients with fluoropyrimidine-resistant advanced colorectal cancer (CRC) derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
    • June 5-8; New Orleans, USA. Alexandria: American Society of Clinical Oncology
    • Stewart G, Chau I, Norman AR, Katopodis O, Topham C, Middleton G, Hill M, Ross P, Oates J, Cunningham D. Elderly patients with fluoropyrimidine-resistant advanced colorectal cancer (CRC) derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Proceedings of the 40th Annual Meeting of American Society of Clinical Oncology; 2004 June 5-8; New Orleans, USA. Alexandria: American Society of Clinical Oncology, 2004: 276
    • (2004) Proceedings of the 40th Annual Meeting of American Society of Clinical Oncology , pp. 276
    • Stewart, G.1    Chau, I.2    Norman, A.R.3    Katopodis, O.4    Topham, C.5    Middleton, G.6    Hill, M.7    Ross, P.8    Oates, J.9    Cunningham, D.10
  • 41
    • 33749536950 scopus 로고    scopus 로고
    • Single-agent irinotecan as second-line weekly chemotherapy in elderly patients with advanced colorectal cancer
    • Rosati G, Cordio S. Single-agent irinotecan as second-line weekly chemotherapy in elderly patients with advanced colorectal cancer. Tumori 2006; 92: 290-294
    • (2006) Tumori , vol.92 , pp. 290-294
    • Rosati, G.1    Cordio, S.2
  • 42
    • 0003253857 scopus 로고    scopus 로고
    • Oxaliplatin and irinotecan: Phase I/II study in 5FU refractory advanced colorectal cancer elderly patients, a second line treatment
    • May 12-15; San Francisco, USA. Alexandria: American Society of Clinical Oncology
    • Bollina R, Toniolo D, Belloni P, Cozzi C, Clerici M. Oxaliplatin and irinotecan: phase I/II study in 5FU refractory advanced colorectal cancer elderly patients, a second line treatment. Proceedings of the 37th Annual Meeting of American Society of Clinical Oncology; 2001 May 12-15; San Francisco, USA. Alexandria: American Society of Clinical Oncology, 2001: 407a
    • (2001) Proceedings of the 37th Annual Meeting of American Society of Clinical Oncology
    • Bollina, R.1    Toniolo, D.2    Belloni, P.3    Cozzi, C.4    Clerici, M.5
  • 43
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • Sastre J, Marcuello E, Masutti B, Navarro M, Gil S, Anton A, Abad A, Aranda E, Maurel J, Valladares M, Maestu I, Carrato A, Vicent JM, Diaz-Rubio E. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 2005; 23: 3545-3551
    • (2005) J Clin Oncol , vol.23 , pp. 3545-3551
    • Sastre, J.1    Marcuello, E.2    Masutti, B.3    Navarro, M.4    Gil, S.5    Anton, A.6    Abad, A.7    Aranda, E.8    Maurel, J.9    Valladares, M.10    Maestu, I.11    Carrato, A.12    Vicent, J.M.13    Diaz-Rubio, E.14
  • 44
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial
    • Souglakos J, Pallis A, Kakolyris S, Mavroudis D, Androulakis N, Kouroussis C, Agelaki S, Xenidis N, Milaki G, Georgoulias V. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial. Oncology 2005; 69: 384-390
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, S.3    Mavroudis, D.4    Androulakis, N.5    Kouroussis, C.6    Agelaki, S.7    Xenidis, N.8    Milaki, G.9    Georgoulias, V.10
  • 45
    • 42149095742 scopus 로고    scopus 로고
    • Irinotecan/5-FU/FA (I-FU) or 5-FU/FA (EU) first-line therapy in older and younger patients with metastatic colorectal cancer: Combined analysis of 2,691 patients in randomised controlled trials
    • June 1-5; Chicago, USA. Alexandria: American Society of Clinical Oncology, 181s
    • Folprecht G, Seymour MT, Saltz L, Douillard JY, Stephens RJ, Van Cutsem E, Rougier P, Maughan TS, Kohne CH. Irinotecan/5-FU/FA (I-FU) or 5-FU/FA (EU) first-line therapy in older and younger patients with metastatic colorectal cancer: Combined analysis of 2,691 patients in randomised controlled trials. Proceedings of the 43rd Annual Meeting of American Society of Clinical Oncology; 2007 June 1-5; Chicago, USA. Alexandria: American Society of Clinical Oncology, 2007: 181s
    • (2007) Proceedings of the 43rd Annual Meeting of American Society of Clinical Oncology
    • Folprecht, G.1    Seymour, M.T.2    Saltz, L.3    Douillard, J.Y.4    Stephens, R.J.5    Van Cutsem, E.6    Rougier, P.7    Maughan, T.S.8    Kohne, C.H.9
  • 46
    • 42149112649 scopus 로고    scopus 로고
    • Combination of irinotecan and 5-fluorouracil, leucovorin in first and second line treatment in elderly patients with metastatic colo-rectal cancer
    • May 13-17; Orlando, USA. Alexandria: American Society of Clinical Oncology, 306s
    • Botto HG, Botto ME. Combination of irinotecan and 5-fluorouracil, leucovorin in first and second line treatment in elderly patients with metastatic colo-rectal cancer. Proceedings of the 41st Annual Meeting of American Society of clinical Oncology; 2005 May 13-17; Orlando, USA. Alexandria: American Society of Clinical Oncology, 2005: 306s
    • (2005) Proceedings of the 41st Annual Meeting of American Society of clinical Oncology
    • Botto, H.G.1    Botto, M.E.2
  • 51
    • 19944432783 scopus 로고    scopus 로고
    • A tailored regimen including capecitabine and oxaliplatin for treating elderly patients with metastatic colorectal carcinoma Southern Italy Cooperative Oncology Group trial 0108
    • Comella P, Gambardella A, Farris A, Maiorino L, Natale D, Massidda B, Casaretti R, Tafuto S, Lorusso V, Leo S. A tailored regimen including capecitabine and oxaliplatin for treating elderly patients with metastatic colorectal carcinoma Southern Italy Cooperative Oncology Group trial 0108. Crit Rev Oncol Hematol 2005; 53: 133-139
    • (2005) Crit Rev Oncol Hematol , vol.53 , pp. 133-139
    • Comella, P.1    Gambardella, A.2    Farris, A.3    Maiorino, L.4    Natale, D.5    Massidda, B.6    Casaretti, R.7    Tafuto, S.8    Lorusso, V.9    Leo, S.10
  • 55
    • 25444443120 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients
    • Rosati G, Cordio S, Tucci A, Blanco G, Bordonaro R, Reggiardo G, Manzione L. Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients. Oncology 2005; 69: 122-129
    • (2005) Oncology , vol.69 , pp. 122-129
    • Rosati, G.1    Cordio, S.2    Tucci, A.3    Blanco, G.4    Bordonaro, R.5    Reggiardo, G.6    Manzione, L.7
  • 59
    • 42149123109 scopus 로고    scopus 로고
    • Tabernero JM, Van Cutsem E, Sastre J, Cervantes A, Van Laethem JL, Humblet Y, Soulié P, Corretgé S, Mueser M, De Gramont A. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results. Proceedings of the 40th Annual Meeting of American Society of Clinical Oncology; 2004 June 5-8; New Orleans, USA. Alexandria: American Society of Clinical Oncology, 2004: 248
    • Tabernero JM, Van Cutsem E, Sastre J, Cervantes A, Van Laethem JL, Humblet Y, Soulié P, Corretgé S, Mueser M, De Gramont A. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results. Proceedings of the 40th Annual Meeting of American Society of Clinical Oncology; 2004 June 5-8; New Orleans, USA. Alexandria: American Society of Clinical Oncology, 2004: 248
  • 61
    • 33846705473 scopus 로고    scopus 로고
    • Single-agent cetuximab as first-line treatment for elderly patients with advanced colorectal cancer. Preliminary results of a TTD phase II study
    • September 29-October 3; Istanbul, Turkey. Oxford: Oxford University Press
    • Sastre J, Aranda E, Grávalos C, Massuti B, Vega-Villegas ME, Soler G, Carrato A, Abad A, Gomez A, Diaz-Rubio E. Single-agent cetuximab as first-line treatment for elderly patients with advanced colorectal cancer. Preliminary results of a TTD phase II study. Proceedings of the 31st ESMO Congress; 2006 September 29-October 3; Istanbul, Turkey. Oxford: Oxford University Press, 2006: 114
    • (2006) Proceedings of the 31st ESMO Congress , pp. 114
    • Sastre, J.1    Aranda, E.2    Grávalos, C.3    Massuti, B.4    Vega-Villegas, M.E.5    Soler, G.6    Carrato, A.7    Abad, A.8    Gomez, A.9    Diaz-Rubio, E.10
  • 62
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an antivascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. Humanization of an antivascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-4599
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 64
    • 0003354373 scopus 로고    scopus 로고
    • First-line irinotecan (C), fluorouracil (F), leucovorin (L) especially improves survival (OS) in metastatic colorectal cancer (MCRC) patients (PT) with favourable prognostic indicators
    • May 20-23; New Orleans, USA. Alexandria: American Society of Clinical Oncology
    • Knight RD, Miller LL, Pirotta N, Elfring GL, Locker PK, Saltz LB. First-line irinotecan (C), fluorouracil (F), leucovorin (L) especially improves survival (OS) in metastatic colorectal cancer (MCRC) patients (PT) with favourable prognostic indicators. Proceedings of the 36th Annual Meeting of American Society of Clinical Oncology; 2000 May 20-23; New Orleans, USA. Alexandria: American Society of Clinical Oncology, 2000: 255a
    • (2000) Proceedings of the 36th Annual Meeting of American Society of Clinical Oncology
    • Knight, R.D.1    Miller, L.L.2    Pirotta, N.3    Elfring, G.L.4    Locker, P.K.5    Saltz, L.B.6
  • 65
  • 66
    • 42149112650 scopus 로고    scopus 로고
    • Capecitabine in combination with oxaliplatin or with irinotecan in elderly patients with advanced colorectal cancer: Preliminary results of a randomized phase II study
    • June 28-July 1; Barcelona, Spain. Oxford: Oxford University Press
    • Rosati G, Cordio S, Bordonaro R, Gebbia V, Rinaldi A, Giannitto G, Borsellino N, Reggiardo G. Capecitabine in combination with oxaliplatin or with irinotecan in elderly patients with advanced colorectal cancer: Preliminary results of a randomized phase II study. Proceedings of the World Congress on Gastrointestinal Cancer; 2007 June 28-July 1; Barcelona, Spain. Oxford: Oxford University Press, 2007: 28-29
    • (2007) Proceedings of the World Congress on Gastrointestinal Cancer , pp. 28-29
    • Rosati, G.1    Cordio, S.2    Bordonaro, R.3    Gebbia, V.4    Rinaldi, A.5    Giannitto, G.6    Borsellino, N.7    Reggiardo, G.8


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