A tailored regimen including capecitabine and oxaliplatin for treating elderly patients with metastatic colorectal carcinoma: Southern Italy Cooperative Oncology Group trial 0108

Critical Reviews in Oncology/Hematology

Volumn 53, Issue 2, 2005, Pages 133-139

  Comella, Pasquale ^a   Gambardella, Antonio ^b   Farris, Antonio ^c   Maiorino, Luigi ^d   Natale, Donato ^e   Massidda, Bruno ^f   Casaretti, Rossana ^a   Tafuto, Salvatore ^g   Lorusso, Vito ^h   Leo, Silvana ^h  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d San Gennnaro Hospital   (Italy)

^e Cities   (Italy)

^f UNIVERSITY OF CAGLIARI   (Italy)

^g City Hospital   (Italy)

^h NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

Capecitabine; Colorectal carcinoma; Combination regimen; Elderly patients; Oxaliplatin

Indexed keywords

CAPECITABINE; OXALIPLATIN;

ABDOMINAL DISCOMFORT; AGED; ANEMIA; BLOOD TOXICITY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE COURSE; DRUG DOSE REGIMEN; DRUG INFUSION; DRUG SAFETY; FEMALE; FUNCTIONAL DISEASE; HAND FOOT SYNDROME; HUMAN; INTESTINE OBSTRUCTION; INTESTINE PERFORATION; ITALY; MALE; METASTASIS; NAUSEA; NEUTROPENIA; PERIPHERAL NEUROPATHY; REVIEW; STOMACH PAIN; STROKE; SURVIVAL TIME; TREATMENT PLANNING; VOMITING; WORLD HEALTH ORGANIZATION;

AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; ITALY; MALE; MAXIMUM TOLERATED DOSE; NEOPLASM METASTASIS; ORGANOPLATINUM COMPOUNDS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 19944432783     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2004.10.008     Document Type: Review

References (26)

1. S.H. Landis, T. Murray, and S. Bolden Cancer statistics, 1999 CA Cancer J Clin 49 1999 8 31
2. R. Zanetti, P. Crosignani, S. Rosso, and C. Vigane Cancer in Italy: incidence data from Cancer Registries. Il Pensiero Scientifico Editore Roma 2 1997 1988 1992
3. S. Chiara, M.T. Nobile, and M. Vincenti Advanced colorectal cancer in the elderly: results of consecutive trials with 5-fluorouracil-based chemotherapy Cancer Chemother Pharmacol 42 1998 336 340
4. R.A. Popescu, A. Norman, P.J. Ross, B. Parikh, and D. Cunningham Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older J Clin Oncol 17 1999 2412 2418
5. B. Daniele, P.D. Simmonds, L.Y. Best, P.J. Ross, and D. Cunningham Should chemotherapy be used as a treatment of advanced colorectal carcinoma (ACC) in patients over 70 years of age? Eur J Cancer 35 1999 1640 1649
6. L.B. Saltz, J.V. Cox, and C. Blanke Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer N Engl J Med 343 2000 905 914
7. J.Y. Douillard, D. Cunningham, and A.D. Roth Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer. A multicentre randomised trial Lancet 355 2000 1041 1047
8. P. Comella, E. Crucitta, and F. De Vita Addition of either irinotecan or methotrexate to bolus fluorouracil and high-dose leucovorin every 2 weeks in advanced colorectal carcinoma: a randomized study of the Southern Italy Cooperative Oncology Group Ann Oncol 13 2002 866 873
9. A. de Gramont, A. Figer, and M. Seymour Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 18 2000 2938 2947
10. S. Giacchetti, B. Perpoint, and R. Zidani Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer J Clin Oncol 18 2000 136 147
11. E. Van Cutsem, C. Twelves, and J. Cassidy Oral Capecitabine compared with intravenous 5-fluorouracil plus leucovorin (Mayo Clinic regimen) in patients with metastatic colorectal cancer: results of a large phase III study J Clin Oncol 19 2001 4097 4106
12. P.M. Hoff, R. Ansari, and G. Batist Comparison of oral Capecitabine versus intravenous 5-fluorouracil plus leucovorin as first line treatment of 605 patients with metastatic colorectal cancer: results of a randomized phase III study J Clin Oncol 19 2001 2282 2292
13. J. Carmichael, T. Popiela, and D. Radstone Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 2002 3617 3627
14. J.-Y. Douillard, P.M. Hoff, and J.R. Skillings Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 2002 3605 3616
15. M.M. Borner, D. Dietrich, and R. Stupp Phase II study of Capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer J Clin Oncol 20 2002 1759 1766
16. M. Zeuli, C. Nardoni, and M.S. Pino Phase II study of Capecitabine and oxaliplatin as first-line treatment in advanced colorectal cancer Ann Oncol 14 2003 1378 1382
17. J. Cassidy, J. Tabernero, and C. Twelves XELOX (capecitabine plus oxaliplatin): active first-line treatment for patients with metastatic colorectal cancer J Clin Oncol 22 2004 2084 2091
18. J. Cassidy, C. Twelves, and E. Van Cutsem First-line oral capecitabine therapy in metastatic colorectal cancer: a favourable safety profile compared with intravenous 5-fluorouracil/leucovorin Ann Oncol 13 2002 566 575
19. M.S. Aapro, M. Extermann, and L. Repetto Evaluation of the elderly with cancer Ann Oncol 11 Suppl. 3 2000 223 229
20. S.M. Lichtman, J.A. Skirvin, and S. Vemulapalli Pharmacology of antineoplastic agents in older cancer patients Crit Rev Oncol Hematol 46 1999 101 114
21. M.E. Charlson, P. Pompei, and K. Ales A new method of classifying prognostic Comorbidity in a longitudinal studies: development and validation J Chronic Dis 40 1987 373 383
22. S. Katz, A. Fords, and R. Moskowitz Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial functions J Chronic Dis 185 1963 914 949
23. M.N. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
24. A.B. Miller, B. Hoogstraten, M. Staquet, and V. Winkler Reporting results of cancer treatment Cancer 47 1981 207 214
25. E.L. Kaplan, and P. Meier Non-parametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
26. P. Comella, A. Farris, and V. Lorusso Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma Br J Cancer 89 2003 992 996