Nuclear factor-κB inhibition improves myocardial contractility in rats with cirrhotic cardiomyopathy

Liver International

Volumn 28, Issue 5, 2008, Pages 640-648

  Liu, Hongqun ^a   Lee, Samuel S ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b NONE   (Canada)

Author keywords

Cell shortening; Cirrhosis; Cytokine; Diastolic; Heart; NF B; Systolic; TNF

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DITHIOCARBAMATE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CELL ISOLATION; CONTROLLED STUDY; DIASTOLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MUSCLE CONTRACTILITY; LIVER CIRRHOSIS; MALE; MICROSCOPY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SYSTOLE; WESTERN BLOTTING; ANIMAL; HEART CONTRACTION; HEART MUSCLE; HYPERTROPHIC CARDIOMYOPATHY; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; LIVER CIRRHOSIS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY;

EID: 42149099316     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01692.x     Document Type: Article

References (30)

1. Barnes PJ, Karin M. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-71.
2. Gupta S, Young D, Sen S. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2005; 289: H20-9.
3. Grabellus F, Levkau B, Sokoll A, et al. Reversible activation of nuclear factor-kappaB in human end-stage heart failure after left ventricular mechanical support. Cardiovasc Res 2002; 53: 124-30.
4. Wong SC, Fukuchi M, Melnyk P, Rodger I, Giaid A. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. Circulation 1998; 98: 100-3.
5. Kubota T, Miyagishima M, Alvarez RJ, et al. Expression of proinflammatory cytokines in the failing human heart: Comparison of recent-onset and end-stage congestive heart failure. J Heart Lung Transplant 2000; 19: 819-24.
6. Torre-Amione G, Kapadia S, Lee J, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996; 93: 704-11.
7. Hirotani S, Otsu K, Nishida K, et al. Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 2002; 105: 509-15.
8. Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci USA 2001; 98: 6668-73.
9. Li Y, Ha T, Gao X, et al. NF-kappaB activation is required for the development of cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol 2004; 287: H1712-20.
10. Kawano S, Kubota T, Monden Y, et al. Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II. Cardiovasc Res 2005; 67: 689-98.
11. Kawamura N, Kubota T, Kawano S, et al. Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy. Cardiovasc Res 2005; 66: 520-9.
12. Liu H, Ma Z, Lee SS. Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Gastroenterology 2000; 118: 937-44.
13. Inserte J, Perello A, Agullo L, et al. Left ventricular hypertrophy in rats with biliary cirrhosis. Hepatology 2003; 38: 589-98.
14. Liu H, Song D, Lee SS. Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat. Am J Physiol Gastrointest Liver Physiol 2001; 280: G68-74.
15. Finucci G, Desideri A, Sacerdoti D, et al. Left ventricular diastolic function in liver cirrhosis. Scand J Gastroenterol 1996; 31: 279-84.
16. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984; 65: 305-11.
17. Ward CA, Liu H, Lee SS. Altered cellular calcium regulatory systems in a rat model of cirrhotic cardiomyopathy. Gastroenterology 2001; 121: 1209-18.
18. Lee SS. Cardiac dysfunction in spontaneous bacterial peritonitis: A manifestation of cirrhotic cardiomyopathy? Hepatology 2003; 38: 1089-91.
19. Jaue DN, Ma Z, Lee SS. Cardiac muscarinic receptor function in rats with cirrhotic cardiomyopathy. Hepatology 1997; 25: 1361-65.
20. Kawano S, Kubota T, Monden Y, et al. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 2006; 291: H1337-44.
21. Jones WK, Brown M, Wilhide M, He S, Ren X. NF-kappaB in cardiovascular disease: Diverse and specific effects of a "general"transcription factor? Cardiovasc Toxicol 2005; 5: 183-202.
22. Kin H, Wang NP, Halkos ME, Kerendi F, Guyton RA, Zhao ZQ. Neutrophil depletion reduces myocardial apoptosis and attenuates NFkappaB activation/TNFalpha release after ischemia and reperfusion. J Surg Res 2006; 135: 170-8.
23. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 1992; 175: 1181-94.
24. Satriano J, Schlondorff D. Activation and attenuation of transcription factor NF-kB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3′:5′-cyclic monophosphate. Evidence for involvement of reactive oxygen species. J Clin Invest 1994; 94: 1629-36.
25. Liu SF, Ye X, Malik AB. Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Mol Pharmacol 1999; 55: 658-67.
26. Li YQ, Zhang ZX, Xu YJ, et al. N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms. Acta Pharmacol Sin 2006; 27: 339-46.
27. Rothwell SE, Richards AM, Pemberton CJ. Resistin worsens cardiac ischaemia-reperfusion injury. Biochem Biophys Res Commun 2006; 349: 400-7.
28. Hall G, Singh IS, Hester L, Hasday JD, Rogers TB. Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. Am J Physiol Heart Circ Physiol 2005; 289: H2103-11.
29. Matsumori A, Sasayama S. The role of inflammatory mediators in the failing heart: Immunomodulation of cytokines in experimental models of heart failure. Heart Fail Rev 2001; 6: 129-36.
30. Watanabe T, Jono H, Han J, Lim DJ, Li JD. Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci USA 2004; 101: 3563-8.