The role of inflammatory mediators in the failing heart: Immunomodulation of cytokines in experimental models of heart failure

Heart Failure Reviews

Volumn 6, Issue 2, 2001, Pages 129-136

  Matsumori, Akira ^a   Sasayama, Shigetake ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Animal models; Cardiomyopathy; Cytokines; Heart failure; Hypertension; Immunomodulation; Ischemic heart disease; Myocarditis

Indexed keywords

AMIODARONE; AMRINONE; BOSENTAN; CYTOKINE; DENOPAMINE; DIGITALIS; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; INTERLEUKIN 10; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PIMOBENDAN; PIPERANOMETOZINE;

ANIMAL MODEL; CONGESTIVE HEART FAILURE; CYTOKINE PRODUCTION; DISEASE EXACERBATION; EXPERIMENTAL MODEL; GENE EXPRESSION; HEART DILATATION; HEART INFARCTION; HEART PROTECTION; HUMAN; HYPERTENSION; IMMUNOMODULATION; INFLAMMATION; ISCHEMIC HEART DISEASE; MYOCARDITIS; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; SURVIVAL; VIRUS MYOCARDITIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HEART FAILURE, CONGESTIVE;

EID: 0035063099     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011457910659     Document Type: Review

References (44)

1. New insights into the pathophysiological role for cytokines in heart failure
2. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
3. Increased circulating cytokines in patients with myocarditis and cardiomyopathy
4. Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial
5. Circulating interleukin-6 in severe heart failure
6. Serial circulating concentrations of c-reactive protein, interleukin (IL)-4, and IL-6 in patients with acute left heart decompensation
7. Animal models: Pathological findings and therapeutic considerations
8. Molecular and immune mechanisms in the pathogenesis of cardiomyopathy - Role of viruses, cytokines, and nitric oxide
9. Cardiac persistence of cardioviral RNA detected by the polymerase chain reaction in a murine model of dilated cardiomyopathy
10. Immunomodulating therapy in viral myocarditis: Effects of tumor necrosis factor, interleukin 2 and anti-interleukin-2 receptor antibody in an animal model
11. Therapeutic effects of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus
12. Persistent expression of cytokine in the chronic stage of viral myocarditis in mice
13. Biology of disease: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin
14. Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats
15. Increased expression of interleukin-1β and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein-1 (MCP-1) in the hypertrophied and failing heart with pressure overload
16. Elevated circulating levels of C-C chemokines in patients with congestive heart failure
17. CXC-chemokines, a new group of cytokines in congestive heart failure - Possible role of platelets and monocytes
18. Plasma levels of the monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction
19. Chemokines and cardiovascular diseases
20. Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemo-attractant protein-1 in human endothelial cells
21. Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats
22. Cytokine gene expression after myocardial infarction in rat hearts. Possible implication in left ventricular remodeling
23. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
24. Anti-monocyte chemoattractant protein-1/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries
25. Negative inotropic effects of cytokines on the heart mediated by nitric oxide
26. Myocardial contractile dysfunction in the systemic inflammatory response syndrome: Role of a cytokine-inducible nitric oxide synthase in cardiac myocytes
27. Differential modulation of cytokine production by drugs: Implications for therapy in heart failure
28. Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages
29. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis
30. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
31. The NF-κB and I-κB proteins: New discoveries and insights
32. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
33. Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain
34. High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: A possible mechanism of digitalis toxicity
35. Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis: A possible mechanism through inhibition of nitric oxide production
36. Amlodipine inhibits the production of cytokines induced by ouabain
37. Denopamine, a β1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis. Suppression tumor necrosis factor-α production in the heart
38. Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators
39. Amiodarone inhibits production of tumor necrosis factor-α by human mononuclear cells. A possible mechanism for its effect in heart failure
40. Regulatory effects of intrinsic IL-10 in IgG immune complex-induced lung injury
41. Interleukin-10 (IL-10) augments allograft arterial disease: Paradoxical effects of IL-10 in vivo
42. Protective role of interleukin-12 in viral myocarditis
43. Effects of intranasal administration of recombinant murine interferon-γ on murine acute myocarditis caused by encephalomyocarditis virus
44. Contribution of endothelin-1 to myocardial injury in a murine model of myocarditis. Acute effects of bosentan, an endothelin receptor antagonist