Small mitochondrial ARF (smARF) is located in both the nucleus and cytoplasm, induces cell death, and activates p53 in mouse fibroblasts

FEBS Letters

Volumn 582, Issue 10, 2008, Pages 1459-1464

  Ueda, Yuko ^a   Koya, Terutsugu ^a   Yoneda Kato, Noriko ^a   Kato, Jun ya ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

MDM2; Nuclear localization; p53; smARF

Indexed keywords

ARF PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN MDM2; PROTEIN P19; PROTEIN P53; PROTEIN SMARF; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FIBROBLAST; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY;

ANIMALS; APOPTOSIS; CELL LINE; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOPLASM; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; MITOCHONDRIA; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE;

EID: 42049120932     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.03.032     Document Type: Article

References (27)

1. Quelle D.E., Zindy F., Ashmun R.A., and Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83 (1995) 993-1000
2. Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
3. Sherr C.J., and Weber J.D. The ARF/p53 pathway. Curr. Opin. Genet Dev. 10 (2000) 94-99
4. Ruas M., and Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378 (1998) F115-F177
5. Sharpless N.E. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat. Res. 576 (2005) 22-38
6. Sherr C.J., et al. p53-Dependent and -independent functions of the Arf tumor suppressor. Cold Spring Harb. Symp. Quant. Biol. 70 (2005) 129-137
7. Weber J.D., Jeffers J.R., Rehg J.E., Randle D.H., Lozano G., Roussel M.F., Sherr C.J., and Zambetti G.P. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 14 (2000) 2358-2365
8. Sugimoto M., Kuo M.L., Roussel M.F., and Sherr C.J. Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing. Mol. Cell 11 (2003) 415-424
9. Bertwistle D., Sugimoto M., and Sherr C.J. Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23. Mol. Cell Biol. 24 (2004) 985-996
10. Korgaonkar C., Hagen J., Tompkins V., Frazier A.A., Allamargot C., Quelle F.W., and Quelle D.E. Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol. Cell Biol. 25 (2005) 1258-1271
11. Itahana K., Bhat K.P., Jin A., Itahana Y., Hawke D., Kobayashi R., and Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol. Cell 12 (2003) 1151-1164
12. Qi Y., Gregory M.A., Li Z., Brousal J.P., West K., and Hann S.R. p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature 431 (2004) 712-717
13. Chen D., Kon N., Li M., Zhang W., Qin J., and Gu W. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121 (2005) 1071-1083
14. Reef S., Zalckvar E., Shifman O., Bialik S., Sabanay H., Oren M., and Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol. Cell 22 (2006) 463-475
15. Chen C., and Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell Biol. 7 (1987) 2745-2752
16. Yoneda-Kato N., Tomoda K., Umehara M., Arata Y., and Kato J.Y. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. EMBO J. 24 (2005) 1739-1749
17. Kato J.Y., Nakamae I., Tomoda K., Fukumoto A., and Yoneda-Kato N. Preparation and characterization of monoclonal antibodies against mouse Jab1/CSN5 protein. Hybridoma (Larchmt) 25 (2006) 342-348
18. Zhang Y., Xiong Y., and Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92 (1998) 725-734
19. Honda R., and Yasuda H. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 18 (1999) 22-27
20. Weber J.D., Taylor L.J., Roussel M.F., Sherr C.J., and Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1 (1999) 20-26
21. Weber J.D., Kuo M.L., Bothner B., DiGiammarino E.L., Kriwacki R.W., Roussel M.F., and Sherr C.J. Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol. Cell Biol. 20 (2000) 2517-2528
22. Korgaonkar C., Zhao L., Modestou M., and Quelle D.E. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol. Cell Biol. 22 (2002) 196-206
23. Bothner B., Lewis W.S., DiGiammarino E.L., Weber J.D., Bothner S.J., and Kriwacki R.W. Defining the molecular basis of Arf and Hdm2 interactions. J. Mol. Biol. 314 (2001) 263-277
24. Leng R.P., et al. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112 (2003) 779-791
25. Dornan D., et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429 (2004) 86-92
26. Stommel J.M., Marchenko N.D., Jimenez G.S., Moll U.M., Hope T.J., and Wahl G.M. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18 (1999) 1660-1672
27. Mihara M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., and Moll U.M. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11 (2003) 577-590