A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 29, Issue 2, 2002, Pages 131-156

  Anissimov, Yuri G ^a   Roberts, Michael S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Compartmental model; Dispersion model; Hepatic disposition; Hepatic elimination; Inverse Gaussian distribution; Secondary vascular compartment

Indexed keywords

PALMITIC ACID; SUCROSE;

ACCURACY; ANIMAL TISSUE; ARTICLE; BOLUS INJECTION; CALCULATION; COMPARTMENT MODEL; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISPERSION; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG ELIMINATION; ENZYME LOCALIZATION; EXPERIMENTAL MODEL; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER FUNCTION; LIVER METABOLISM; NONHUMAN; NONLINEAR SYSTEM; NORMAL DISTRIBUTION; PRIORITY JOURNAL; RAT;

ANIMALS; LINEAR MODELS; LIVER; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS; RATS;

EID: 0036553382     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019703607647     Document Type: Article

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