Novel biomarkers of allograft rejection: 'Omics' approaches start to deliver

Current Opinion in Organ Transplantation

Volumn 10, Issue 4, 2005, Pages 295-300

  Raulf, Friedrich ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Genomic profiling; Kidney transplantation; Metabolomics; Proteomics; Transcriptomics

Indexed keywords

BIOLOGICAL MARKER;

BLOOD; COMPARATIVE STUDY; DIAGNOSTIC PROCEDURE; GENOMICS; GRAFT REJECTION; HUMAN; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; METABOLOMICS; PATHOPHYSIOLOGY; PREDICTION; PROGNOSIS; PROTEOMICS; REVIEW; SENSITIVITY ANALYSIS; TRANSCRIPTOMICS; VALIDATION PROCESS;

EID: 28044465127     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/01.mot.0000184016.85831.dc     Document Type: Review

References (36)

1. Akalin E, Hendrix RC, Polavarapu RG, et al. Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology. Transplantation 2001; 72:948-953.
2. Donauer J, Rumberger B, Klein M, et al. Expression profiling on chronically rejected transplant kidneys. Transplantation 2003; 76:539-547.
3. Scherer A, Krause A, Walker JR, et al. Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies. Transplantation 2003; 75:1323-1330.
4. Sarwal M, Chua MS, Kambham N, et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349:125-138.
5. Park WD, Grande JP, Ninova D, et al. Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury. Am J Transplant 2003; 3:952-960.
6. Hauser P, Schwarz C, Mitterbauer C, et al. Genome-wide gene-expression patterns of donor kidney biopsies distinguish primary allograft function. Lab Invest 2004; 84:353-361.
7. Flechner SM, Kurian SM, Head SR, et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4:1475-1489. The authors report the first identification of gene expression signatures for both biopsies and peripheral blood lymphocytes in renal transplant patients.
8. Li B, Ding R, Dadhania D, et al. Molecular footprints of chronic allograft nephropathy in histologically normal allograft biopsies from clinically stable renal allograft recipients. Am J Transplant 2005; 5(Suppl 11):390.
9. H1 T-cell activation.
10. Mansfield ES, Sarwal MM. Arraying the orchestration of allograft pathology (Minireview). Am J Transplant 2004; 4:853-862.
11. Einecke G, Melk A, Ramassar V, et al. Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection. Am J Transplant 2005; 5:1827-1836.
12. Raulf F, Roth L, Pally C, et al. Transcriptomics of a rat renal allograft model identified early acute rejection markers in blood with cross-species, organindependent relevance. Am J Transplant 2005; 5(Suppl 11):238.
13. Zhang S, Herzyk P, Robbins RC, et al. Microarray gene expression analysis of kidney allograft rejection under single drug immunosuppression in non-human primates. Am J Transplant 2005; 5(Suppl 11):451.
14. Avihingsanon Y, Ma N, Pavlakis M, et al. On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol 2005; 16:1542-1548.
15. Zhang M, Mansfield ES, Shah S, et al. Non-invasive biomarkers for prediction of acute rejection and graft loss in pediatric renal allograft patients. Am J Transplant 2005; 5(Suppl 11):389.
16. Horwitz PA, Tsai EJ, Putt ME, et al. Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation 2004; 110:3815-3821.
17. Marboe CC, Billingham M, Eisen HJ, et al. Refining pathological classification of acute rejection in cardiac allograft recipients: A multicenter study using peripheral blood gene expression profiling. J Heart Lung Transplant 2004; 23:S42.
18. Evans RW, Williams GE, Baron HM, et al. The economic implications of non-invasive molecular testing for cardiac allograft rejection. Am J Transplant 2005; 5:1553-1558.
19. Tatapudi RR, Muthukumar T, Dadhania D, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004; 65:2390-2397.
20. Kotsch K, Mashreghi MF, Bold G, et al. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation 2004; 77:1866-1875. This comprehensive TaqMan study of 12 genes in urine of transplant patients with transcript kinetics of individual patients also discusses the challenges of RNA analytics in urine.
21. Thongboonkerd V. Proteomics in nephrology: current status and future directions. Am J Nephrol 2004; 24:360-378.
22. Voshol H, Brendlen N, Müller D, et al. Evaluation of biomarker discovery approaches to detect protein biomarkers of acute renal allograft rejection. J Proteome Res 2005; 4:1192-1199.
23. Clarke W, Silverman BC, Zhang Z, et al. Characterization of renal allograft rejection by urinary proteomic analysis. Ann Surg 2003; 237:660-664.
24. O'Riordan E, Orlova TN, Mei JJ, et al. Bioinformatic analysis of the urine proteome of acute allograft rejection. J Am Soc Nephrol 2004; 15:3240-3248.
25. Wittke S, Haubitz M, Walden M. Detection of acute tubolointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant 2005; 5:2479-2488.
26. Schaub S, Wilkins J, Weiler T, et al. Urine protein profiling with surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry. Kidney Int 2004; 65:323-332.
27. Schaub S, Rush D, Wilkins J, et al. Proteomic-based detection of urine proteins associated with acute renal allograft rejection. J Am Soc Nephrol 2004; 15:219-227.
28. Schaub S, Wilkins JA, Antonovici M, et al. Proteomic-based identification of cleaved urinary β2-microglobulin as a potential marker for acute tubular injury in renal allografts. Am J Transplant 2005; 5:729-738. This is the first example that unbiased proteomic profiling led to the identification of urine proteins as biomarker candidates for acute rejection.
29. 1H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int 2005; 67:1142-1151.
30. Zhang J, McCombie G, Guenat C, Knochenmuss R. FT-ICR mass spectrometry in the drug discovery process. Drug Discov Today 2005; 10:635-642.
31. Brandacher G, Cakar F, Winkler C, et al. Serum and urinary expression profiles of the immunomodulatory enzyme Indoleamine 2,3-dioxygenase in patients after kidney transplantation. Am J Transplant 2005; 5(Suppl 11):158-159.
32. Le Meur Y, Leprivey-Lorgeot V, Mons S, et al. Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection. Nephrol Dial Transplant 2004; 19:1862-1865.
33. Striz I, Eliska K, Eva H, et al. Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft. Immunol Lett 2005; 99:30-35.
34. Hu H, Aizenstein BD, Puchalski A, et al. Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. Am J Transplant 2004; 4:432-437.
35. Lazzeri E, Rotondi M, Mazzinghi B, et al. High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathy. Transplantation 2005; 79:1215-1220.
36. + T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure. Int Arch Allergy Immunol 2004; 133:276-284.