Early loss of renal transcripts in kidney allografts: Relationship to the development of histologic lesions and alloimmune effector mechanisms

American Journal of Transplantation

Volumn 7, Issue 5, 2007, Pages 1121-1130

  Einecke, G ^a   Broderick, G ^a   Sis, B ^a   Halloran, P F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Delayed type hypersensitivity (DTH); Epithelial cells; Gene expression; Injury and repair; Kidney transplantation; Knockout mice; Mice; T cell effector molecules; Tubulitis

Indexed keywords

TRANSCRIPTOME;

ALLOIMMUNITY; ALLOIMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELAYED GRAFT FUNCTION; DISEASE SEVERITY; EFFECTOR CELL; GENE EXPRESSION; GRAFT FAILURE; INFLAMMATORY INFILTRATE; ISOGRAFT; KIDNEY ALLOGRAFT; KIDNEY EPITHELIUM; KIDNEY GRAFT; KIDNEY INJURY; KIDNEY PARENCHYMA; KIDNEY TUBULE DISORDER; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENAL GRAFT DYSFUNCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTOMICS;

ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; CARRIER PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GRAFT REJECTION; GRANZYMES; INTEGRIN ALPHA CHAINS; KIDNEY; KIDNEY TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 34247391990     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01797.x     Document Type: Article

References (19)

1. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999 55 : 713 723.
2. Solez K, Racusen LC, Marcussen N et al. Morphology of ischemic acute renal failure, normal function, and cyclosporine toxicity in cyclosporine-treated renal allograft recipients. Kidney Int 1993 43 : 1058 1067.
3. Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993 44 : 411 422.
4. Einecke G, Fairhead T, Hidalgo LG et al. Tubulitis and Epithelial Cell Alterations in Mouse Kidney Transplant Rejection Are Independent of CD103, Perforin or Granzymes A/B. Am J Transplant 2006 6 : 2109 2120.
5. Jabs WJ, Sedlmeyer A, Ramassar V et al. Heterogeneity in the evolution and mechanisms of the lesions of kidney allograft rejection in mice. Am J Transplant 2003 3 : 1501 1509.
6. Halloran PF, Miller LW, Urmson J et al. IFN-gamma alters the pathology of graft rejection: Protection from early necrosis. J Immunol 2001 166 : 7072 7081.
7. Einecke G, Melk A, Ramassar V et al. Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection. Am J Transplant 2005 5 : 1827 1836.
8. Goes N, Urmson J, Ramassar V, Halloran PF. Ischemic acute tubular necrosis induces an extensive local cytokine response: Evidence for induction of interferon-γ, transforming growth factorβ-1, granulocyte-macrophage colony-stimulating factor, interleukin-2 and interleukin-10. Transplant 1995 59 : 565 572.
9. Gentleman R, Carey VJ, Huber W, Irizarry R, Dudoit S. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. XII ed. 2005.
10. Smyth G. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Statistical Application in Genetics and Molecular Biology 21204 3 : Article 3.
11. Halloran PF, Urmson J, Ramassar V et al. Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B. Am J Transplant 2004 4 : 705 712.
12. Einecke G, Mueller TF, Famulski KS, Ramassar V, Sis B, Halloran PF. Cytotoxic T cells, Interferon gamma and the renal response: Pathogenesis-based transcript sets have high diagnostic value in human kidney allograft rejection. Am J Transplant 2006 6 : 465 472.
13. Adams AB, Williams MA, Jones TR et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003 111 : 1887 1895.
14. Sinha S, Heagerty AM, Shuttleworth CA, Kielty CM. Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury. Cardiovasc Res 2002 53 : 971 983.
15. Eickelberg O, Pansky A, Koehler E et al. Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J 2001 15 : 797 806.
16. Fairweather D, Frisancho-Kiss S, Yusung SA et al. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Am J Pathol 2004 165 : 1883 1894.
17. Robertson H, Ali S, McDonnell BJ, Burt AD, Kirby JA. Chronic renal allograft dysfunction: The role of T cell-mediated tubular epithelial to mesenchymal cell transition. J Am Soc Nephrol 2004 15 : 390 397.
18. Du C, Jiang J, Guan Q et al. Renal tubular epithelial cell self-injury through Fas/Fas ligand interaction promotes renal allograft injury. Am J Transplant 2004 4 : 1583 1594.
19. Schnermann J. Homer W. Smith Award lecture. The juxtaglomerular apparatus: from anatomical peculiarity to physiological relevance. J Am Soc Nephrol 2003 14 : 1681 1694.