Transcription factors as regulators of steroidogenic P-450 enzymes

European Journal of Clinical Investigation, Supplement

Volumn 30, Issue 3, 2000, Pages 14-20

  Peter, Michael ^a,c   Dubuis, J M ^b  

^a Sanitas Ostseeklinik Boltenhagen   (Germany)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c SANITAS Ostseekilink Boltenhagen   (Germany)

Author keywords

DAX 1; Review; Steroidogenesis; Steroidogenic factor 1

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; HYPOPHYSIS HORMONE; NUCLEAR RECEPTOR DAX 1; OXIDOREDUCTASE; STEROID HORMONE; STEROID MONOOXYGENASE; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADRENAL GLAND; CONFERENCE PAPER; ENZYME REGULATION; GENE EXPRESSION REGULATION; GONAD; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STEROIDOGENESIS; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

EID: 0034483401     PISSN: 0960135X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2000.0300s3014.x     Document Type: Conference Paper

References (50)

1. The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
2. Molecular endocrinology of hydroxysteroid dehydrogenases
3. Molecular biology of steroid hormone biosynthesis
4. Disorders of steroid 11β-hydroxylase isoenzymes
5. Molecular genetics and pathophysiology of 17β-hydroxysteroid dehydrogenase 3 deficiency
6. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis
7. Biochemical diversity of cAMP-dependent transcription of steroid hydroxylase genes in the adrenal cortex
8. Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein
9. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase
10. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nur-1 in the adrenal glands
11. Steroidogenic factor 1: A key determinant of endocrine development and function
12. The role of DAX-1 in reproduction
13. Structural characterization of human Ad4 BP (SF-1) gene
14. Cloning and sequence analysis of the human gene encoding steroidogenic factor 1
15. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
16. Developmental expression of mouse steroidogenic factor 1, an essential regulator of steroid hydroxylases
17. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
18. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
19. Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme
20. Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells
21. Contribution of Ad4 BP, a steroidogenic cell-specific transcription factor, to regulation of the human CYP11A and bovine CYP11β genes through their distal promoters
22. Multiple regulatory elements determine adrenocortical expression of steroid 21-hydroxylase
23. Activation of CYP11A and CYP11β gene promoters by the steroidogenic cell-specific transcription factor, Ad4 BP
24. Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11β-hydroxylase
25. Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3′, 5′ -monophosphate-responsive sequence in the bovine CYP17 gene
26. The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3′, 5′ -monophosphate-mediated transcriptional activation of rat cytochrome p450c 17 (17-alpha-hydroxylase/c 17-20 lyase)
27. Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3′, 5′ -monophosphate induction in granulosa cells and constitutive expression in R2C Leydig cells
28. Steroidogenic factor-1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues
29. Ad4 BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP 19) gene in ovary
30. 4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester
31. Steroidogenic factor 1-dependent promoter activity of the human the steroidogenic acute regulatory protein (STAR) gene
32. Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein (STAR)
33. The mouse ACTH receptor gene: Cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor SF1
34. Transcriptional regulation of the genes encoding the cytochrome P450 steroid hydroxylases
35. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
36. Congenital adrenal hypoplasia: Clinical spectrum, experience with hormonal diagnosis and report on new point mutations of the DAX-1 gene
37. Familial congenital adrenal hypoplasia
38. Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: Evidence that DAX-1 mutations lead to combined hypothalamic and pituitary defects in gonadotropin production
39. Genomic sequence of the DAX1 gene: An orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
40. Hormonal and developmental regulation of DAX-1 expression in Sertoli cells
41. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: Potential links in endocrine development
42. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
43. Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita
44. Role of Ahch in gonadal development and gametogenesis
45. A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal
46. Dax-1 antagonizes Sty action in mammalian sex determination
47. DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
48. DAX-1 blocks steroid production at multiple levels
49. DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita
50. A mutation in the gene encoding steroidgenicfactor-1 causes sex reveral and adrenal failure in humans