Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection

Genomics

Volumn 91, Issue 5, 2008, Pages 423-432

  Mukherjee, Shankar ^a   Nagajyothi, Fnu ^a   Mukhopadhyay, Aparna ^a   Machado, Fabiana S ^b   Belbin, Thomas J ^a   Campos de Carvalho, Antonio ^c   Guan, Fangxia ^a,d   Albanese, Chris ^e   Jelicks, Linda A ^a   Lisanti, Michael P ^f,h,i   Silva, Joao S ^g   Spray, David C ^a   Weiss, Louis M ^a   Tanowitz, Herbert B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d ZHENGZHOU UNIVERSITY   (China)

^e GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^f THOMAS JEFFERSON UNIVERSITY   (United States)

^g UNIVERSITY OF SÃO PAULO   (Brazil)

^h UNIVERSITY OF GENOA   (Italy)

ⁱ G GASLINI INSTITUTE   (Italy)

Author keywords

Cardiomyopathy; Chagas disease; Fas; Gene array analysis; Infection inflammation; Trypanosoma cruzi; Cyclins

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ACUTE DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MODEL; EMBRYO; FLAGELLATE; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; HEART; HEART MUSCLE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; UNINDEXED SEQUENCE;

ANIMALS; CHAGAS CARDIOMYOPATHY; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; MODELS, ANIMAL; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRYPANOSOMA CRUZI;

MURINAE; MUS; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 42049104924     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2008.01.008     Document Type: Article

References (50)

1. Tanowitz H.B., et al. Chagas disease. Clin. Microbiol. Rev. 5 (1992) 400-419
2. Kierszenbaum F. Mechanisms of pathogenesis in Chagas disease. Acta Parasitol. 52 (2007) 1-12
3. Factor S.M., Cho S., Wittner M., and Tanowitz H.B. Abnormalities of the coronary microcirculation in acute murine Chagas' disease. Am. J. Trop. Med. Hyg. 34 (1985) 246-253
4. Rossi M.A., Ramos S.G., and Bestetti R.B. Chagas' heart disease: clinical-pathological correlation. Front. Biosci. 8 (2003) 94-109
5. Tanowitz H.B., et al. Compromised microcirculation in acute murine Trypanosoma cruzi infection. J. Parasitol. 82 (1996) 124-130
6. Petkova S.B., et al. Myocardial expression of endothelin-1 in murine Trypanosoma cruzi infection. Cardiovasc. Pathol. 9 (2000) 257-265
7. Factor S.M., Tanowitz H.B., Wittner M., and Ventura M.C. Interstitial connective tissue matrix alterations in acute murine Chagas' disease. Clin. Immunol. Immunopathol. 68 (1993) 147-152
8. Kirchhoff L.V., Weiss L.M., Wittner M., and Tanowitz H.B. Parasitic diseases of the heart. Front. Biosci. 9 (2004) 706-723
9. Acquatella H. Echocardiography in Chagas heart disease. Circulation 115 (2007) 1124-1131
10. Zhong W., et al. Hypertrophic growth in cardiac myocytes is mediated by Myc through a cyclin D2-dependent pathway. EMBO J. 25 (2006) 3869-3879
11. Huang H., et al. Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice. J. Mol. Cell Cardiol. 31 (1999) 75-88
12. Teixeira M.M., Gazzinelli R.T., and Silva J.S. Chemokines, inflammation and Trypanosoma cruzi infection. Trends Parasitol. 18 (2002) 262-265
13. Medina F.A., et al. Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain). Microbes Infect. 9 (2007) 325-333
14. Tanowitz H.B., et al. Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Am. J. Trop. Med. Hyg. 43 (1990) 274-281
15. Ashton A.W., et al. Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J. Exp. Med. 204 (2007) 929-940
16. Tanowitz H.B., et al. Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect. Immun. 73 (2005) 2496-2503
17. Mukherjee S., et al. Microarray technology in the investigation of diseases of myocardium with special reference to infection. Front. Biosci. 11 (2006) 1802-1813
18. Belbin T.J., et al. Molecular profiling of tumor progression in head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 131 (2005) 10-18
19. Garg N., Popov V.L., and Papaconstantinou J. Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development. Biochim. Biophys. Acta 1638 (2003) 106-120
20. Garg N., Gerstner A., Bhatia V., DeFord J., and Papaconstantinou J. Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways. Biochem. J. 381 Pt 3 (2004) 743-752
21. Mukherjee S., et al. Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy. Parasitol. Res. 91 (2003) 187-196
22. Nanni L., Romualdi C., Maseri A., and Lanfranchi G. Differential gene expression profiling in genetic and multifactorial cardiovascular diseases. J. Mol. Cell. Cardiol. 41 (2006) 934-948
23. Liang Y., Lu X., and Perkins D.L. Microarray analysis of gene expression in murine cardiac graft infiltrating cells. Methods Mol. Biol. 366 (2007) 3-12
24. Jelicks L.A., et al. Application of cardiac gated magnetic resonance imaging in murine Chagas' disease. Am. J. Trop. Med. Hyg. 61 (1999) 207-214
25. Chandra M., et al. Cardioprotective effects of Verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil strain): an echocardiographic study. Int. J. Parasitol. 32 (2002) 207-215
26. De Souza A.P., et al. Effects of early and late verapamil administration on development of cardiomyopathy in experimental chronic Trypanosoma cruzi infection (Brazil strain). Parasitol. Res. 92 (2004) 496-501
27. Jelicks L.A., et al. Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. Int. J. Parasitol. 32 (2002) 1497-1506
28. Machado F.S., et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J. Infect. Dis. 191 (2005) 627-636
29. Borges M., Da Silva A.C., Sereno D., and Ouaissi A. Peptide-based analysis of the amino acid sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor. Immunology 109 (2003) 147-155
30. Fernandez-Gomez R., Esteban S., Gomez-Corvera R., Zoulika K., and Ouaissi A. Trypanosoma cruzi: Tc52 released protein-induced increased expression of nitric oxide synthase and nitric oxide production by macrophages. J. Immunol. 160 (1998) 3471-3479
31. Tarleton R.L. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. J. Immunol. 140 (1988) 2769-2773
32. Geraghty P., Greene C.M., O'Mahony M., O'Neill S.J., Taggart C.C., and McElvaney N.G. Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. J. Biol. Chem. 282 (2007) 33389-33395
33. Doumas S., Kolokotronis A., and Stefanopoulos P. Anti-inflammatory and antimicrobial roles of secretory leukocyte protease inhibitor. Infect. Immun. 73 (2005) 1271-1274
34. Mukherjee S., et al. Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Infect. Immun. 72 (2004) 5274-5282
35. Huang H., et al. Activation of transcription factors AP-1 and NF-kappa B in murine chagasic myocarditis. Infect. Immun. 71 (2003) 2859-2867
36. Nagajyothi F., et al. Cyclin and caveolin expression in an acute model of murine chagasic myocarditis. Cell Cycle 5 (2006) 107-112
37. + T cell death by apoptosis in experimental Chagas' disease. J. Immunol. 154 (1995) 744-752
38. Lopes M.F., et al. Increased susceptibility of Fas ligand-deficient gld mice to Trypanosoma cruzi infection due to a Th2-biased host immune response. Eur. J. Immunol. 29 (1999) 81-89
39. + B lymphocytes susceptible to Fas/Fas ligand-mediated fratricide. J. Immunol. 168 (2002) 3965-3973
40. Ferguson T.A., and Griffith T.S. A vision of cell death: Fas ligand and immune privilege 10 years later. Immunol. Rev. 213 (2006) 228-238
41. de Oliveira G.M., et al. Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection. Am. J. Pathol. 171 (2007) 79-86
42. Giroux M., and Denis F. CD1d-unrestricted human NKT cells release chemokines upon Fas engagement. Blood 105 (2005) 703-710
43. Umemura M., et al. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol. 18 (2004) 1099-1108
44. Shudo K., et al. The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur. J. Immunol. 31 (2001) 2504-2511
45. Cunha-Neto E., et al. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am. J. Pathol. 167 (2005) 305-313
46. Dudoit S., and Speed T.P. A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data from sib-pairs. Biostatistics 1 (2000) 1-26
47. Eisen M.B., Spellman P.T., Brown P.O., and Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14863-14868
48. Huang H., et al. Myocardial G proteins in murine Chagas' disease. J. Parasitol. 83 (1997) 663-670
49. Meirelles M.N., de Araujo-Jorge T.C., Miranda C.F., de Souza W., and Barbosa H.S. Interaction of Trypanosoma cruzi with heart muscle cells: ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro. Eur. J. Cell Biol. 41 (1986) 198-206
50. Machado F.S., Martins G.A., Aliberti J.C., Mestriner F.L., Cunha F.Q., and Silva J.S. Trypanosoma cruzi-infected cardiomyocytes produce chemokines and cytokines that trigger potent nitric oxide-dependent trypanocidal activity. Circulation 102 (2000) 3003-3008