Peptide-based analysis of the amino acid sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor

Immunology

Volumn 109, Issue 1, 2003, Pages 147-155

  Borges, Margarida ^a   Da Silva, Anabela Cordeiro ^b   Sereno, Denis ^a   Ouaissi, Ali ^a  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 2; PROTEIN TC52; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; CYTOKINES; DOWN-REGULATION; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; OVALBUMIN; PEPTIDE FRAGMENTS; PROTOZOAN PROTEINS; SPLEEN; TRYPANOSOMA CRUZI; VIRULENCE;

EID: 0038291611     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01637.x     Document Type: Article

References (33)

1. Takle GB, Snary D. South American trypanosomiasis (Chagas' disease). In: Warren KS, ed. Immunology of Parasitic Infections. Oxford: Blackwell Scientific Publications, 1993:213-36.
2. Ley V, Robbins ES, Nussenzweig V, Andrews NW. The exit of Trypanosoma cruzi from the phagosome is inhibited by raising the pH of acidic compartments. J Exp Med 1990; 171:401-13.
3. Andrews NW, Abrams CK, Slatin SL, Griffiths GA. T. cruzi-secreted protein immunologically related to the complement component C9: evidence for membrane pore-forming activity at low pH. Cell 1990; 61:1277-87.
4. Tarleton RL, Zhang L. Chagas' disease etiology: autoimmunity or parasite persistence? Parasitol Today 1999; 15:94-9.
5. Brener Z. Immunity to Trypanosoma cruzi. Adv Parasitol 1980; 18:247-92.
6. Sztein MT, Kierszenbaum F. Mechanisms of development of immunosuppression during trypanosoma infections. Parasitol Today 1993; 9:424-8.
7. Abrahamsohn IA, Coffman RL. Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infection. J Immunol 1995; 155:3955-63.
8. Lopes MF, da Veiga V, Santos A, Fonseca ME, DosReis GA. Activation-induced CD4+ T cell death by apoptosis in experimental Chagas disease. J Immunol 1995; 154:744-52.
9. Camargo MM, Almeida IC, Pemira MES, Ferguson MAJ, Travassos LR, Gazzinelli RT. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. J Immunol 1997; 158:5890-901.
10. Gorelik G, Cremaschi G, Borda E, Sterin-Borda L. Trypanosoma cruzi antigens down-regulate T lymphocyte proliferation by muscarinic cholinergic receptor-dependent release of PGE2. Acta Physiol Pharmacol Ther Latinoam 1998; 48:115-23.
11. Kierszenbaum F, de Diego JL, Fresno M, Sztein MB. Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes. Eur J Immunol 1999; 29:1684-91.
12. Schöneck R, Marry B, Taibi A, Billaut-Mulot O, Gras-Masse H, Capron A, Ouaissi A. Trypanosoma cruzi cDNA encodes a tandemely repeated domain structure characteristic of small stress proteins and glutathione S-transferases. Biol Cell 1994; 80:1-10.
13. Ouaissi A, Guevara-Espinoza A, Chabe F, Gomez-Corvera R, Taibi A. A novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione. Immunol Lett 1995; 48:221-4.
14. Fernandez-Gomez R, Esteban S, Gomez-Corvera R, Zoulika K, Ouaissi A. Trypanosoma cruzi: Tc52 released protein-induced increased expression of nitric oxide synthase and nitric oxide production by macrophages. J Immunol 1998; 160:3471-9.
15. Ouaissi A, Guilvard E, Delneste Y, Caron G, Magistrelli G, Herbault N, Thibleont N, Jeannin P. The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J Immunol 2002; 168:6366-74.
16. Moutiez M, Aumercier M, Schöneck R et al. Purification and characterization of a trypanotione-glutathione thioltransferase from Trypanosoma cruzi. Biochem J 1995; 310:433-7.
17. Ouaissi A, Cordeiro da Silva A, Guevara AG, Borges M, Guilvard E. Trypanosoma cruzi-induced host immune system dysfunction: a rationale for parasite immunosuppressive factor(s) encoding gene targeting. J Biomed Biotechnol 2001; 1:11-7.
18. Aichele P, Brduscha-Riem K, Zinkemagel RM, Hengartner H, Pircher H. T cell priming versus T cell tolerance induced by synthetic peptides. J Exp Med 1995; 182:261-6.
19. Tarleton RL. The role of T cells in Trypanosoma cruzi infections. Parasitol Today 1995; 11:7-9.
20. Allaoui A, Francois C, Zemzoumi K, Guilvard E, Ouaissi A. Intracellular growth and metacyclogenesis defect in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele. Mol Microbiol 1999; 32:1273-86.
21. Tarleton RL. Trypanosoma cruzi-induced suppression of IL-2 production. I. Evidence for the presence of IL-2-producing cells. J Immunol 1988; 140:2763-8.
22. Bertoletti A, Sette A, Chisari FV, Penna A, Levrero M, De Carli M, Fiaccadori F, Ferrari C. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994; 369:407-10.
23. Klenerman P, Rowland-Jones S, McAdam S et al. Cytotoxic T cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 1994; 369:403-7.
24. Gilbert SC, Plebanski M, Gupta S et al. Association of malaria parasite population structure, HLA and immunological antagonism. Science 1998; 279:1173-7.
25. Millar AE, Wleklinski-Lee M, Kahn SJ. The surface protein super-family of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic. J Immunol 1999; 162:6092-9.
26. Amorigena S, Bonnerot C. Role of B-cell and Fc receptors in the selection of T-cell epitopes. Curr Opin Immunol 1998; 10:88-92.
27. Guillet JG, Hoebeke J, Lengagne R, Tare K, Borras-Herrera F, Strosberg AD, Borras-Cuesta F. Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences. J Mol Recognit 1991; 4:17-25.
28. Roy S, Scherer MT, Briner TJ, Smith JA, Gefter ML. Murine MHC polymorphism and T cell specificities. Science 1989; 244:572-4.
29. Guéry J, Adorini L. Selective imunosuppression of class II-restricted T cells by MHC class II-binding peptides. Crit Rev Immunol 1993; 13:195-206.
30. Ouaissi A, Ouaissi M, Sereno D, Glutathione S-transferases and related proteins from pathogenic human parasites behave as immunomodulatory factors. Immunol Lett 2002; 81:159-64.
31. Oppenheim JJ, Kovacs EJ, Matsushima K et al. There is more than one interleukin 1. Immunol Today 1986; 7:45-8.
32. Antoni G, Presentini R, Perin F et al. A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity. J Immunol 1986; 137:3201-4.
33. Boraschi D, Nencioni L, Villa L et al. In vivo stimulation and restoration of the immune response by the non-inflammatory fragment 163-171 of human interleukin 1 beta. J Exp Med 1988; 168:675-86.