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Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro
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Tong L, Phan TK, Robinson KL, et al. Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro. Antimicrob Agents Chemother 2007; 51:3498-3504.
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Tong, L.1
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Does tenofovir influence efavirenz pharmacokinetics?
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Rotger M, Colombo S, Furrer H, et al. Does tenofovir influence efavirenz pharmacokinetics? Antivir Ther 2007; 12:115-118.
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Antivir Ther
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Rotger, M.1
Colombo, S.2
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47
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Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients
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New information is presented that indicates that ritonavir-boosted protease inhibitors lower plasma abacavir
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Waters LJ, Moyle G, Bonora S, et al. Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients. Antivir Ther 2007; 12:825-830. New information is presented that indicates that ritonavir-boosted protease inhibitors lower plasma abacavir.
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Antivir Ther
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Waters, L.J.1
Moyle, G.2
Bonora, S.3
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48
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P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
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Shaik N, Giri N, Pan G, Elmquist WF. P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution. Drug Metab Dispos 2007; 35:2076-2085.
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Drug Metab Dispos
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Shaik, N.1
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Pan, G.3
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49
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Dumond JB, Yeh RF, Patterson KB, et al. Antiretroviral drug exposure in the female genital tract: implications for oral pre and postexposure prophylaxis. AIDS 2007; 21:1899-1907. This report provides critical information on NRTI penetration into the female genital tract, which is important given the interest in using NRTIs as pre-exposure and post-exposure prophylaxis. The study evaluated first dose and steady-state data and AUCs.
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Dumond JB, Yeh RF, Patterson KB, et al. Antiretroviral drug exposure in the female genital tract: implications for oral pre and postexposure prophylaxis. AIDS 2007; 21:1899-1907. This report provides critical information on NRTI penetration into the female genital tract, which is important given the interest in using NRTIs as pre-exposure and post-exposure prophylaxis. The study evaluated first dose and steady-state data and AUCs.
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50
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33645391801
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Best BM, Mirochnick M, Capparelli EV, et al. Impact of pregnancy on abacavir pharmacokinetics. AIDS 2006; 20:553-560. This is an intensive evaluation of abacavir plasma pharmacokinetics in late pregnancy versus postpartum.
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Best BM, Mirochnick M, Capparelli EV, et al. Impact of pregnancy on abacavir pharmacokinetics. AIDS 2006; 20:553-560. This is an intensive evaluation of abacavir plasma pharmacokinetics in late pregnancy versus postpartum.
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51
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Arribas JR, Pozniak AL, Gallant JE, et al. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis. J Acquir Immune Defic Syndr 2008; 47:74-78. This is an example of better tolerability and long-term lipoatrophic outcomes in TDF/emtricitabine recipients versus zidovudine/lamivudine.
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Arribas JR, Pozniak AL, Gallant JE, et al. Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis. J Acquir Immune Defic Syndr 2008; 47:74-78. This is an example of better tolerability and long-term lipoatrophic outcomes in TDF/emtricitabine recipients versus zidovudine/lamivudine.
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52
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Less lipoatrophy and better lipid profile with abacavir as compared to stavudine: 96-week results of a randomized study
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Example of better long-term lipoatrophic outcomes for abacavir recipients versus stavudine
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Podzamczer D, Ferrer E, Sanchez P, et al. Less lipoatrophy and better lipid profile with abacavir as compared to stavudine: 96-week results of a randomized study. J Acquir Immune Defic Syndr 2007; 44:139-147. Example of better long-term lipoatrophic outcomes for abacavir recipients versus stavudine.
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(2007)
J Acquir Immune Defic Syndr
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, pp. 139-147
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Podzamczer, D.1
Ferrer, E.2
Sanchez, P.3
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53
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The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients
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Milinkovic A, Martinez E, Lopez S, et al. The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients. Antivir Ther 2007; 12:407-415.
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(2007)
Antivir Ther
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Milinkovic, A.1
Martinez, E.2
Lopez, S.3
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55
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HLA-B*5701 screening for susceptibility to abacavir hypersensitivity
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Lucas A, Nolan D, Mallal S. HLA-B*5701 screening for susceptibility to abacavir hypersensitivity. J Antimicrob Chemother 2007; 59:591-593.
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J Antimicrob Chemother
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Lucas, A.1
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56
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Chemoprophylaxis of HIV infection: Moving forward with caution
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Grant RM, Wainberg MA. Chemoprophylaxis of HIV infection: moving forward with caution. J Infect Dis 2006; 194:874-876.
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J Infect Dis
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Grant, R.M.1
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Peterson L, Taylor D, Roddy R, et al. Tenofovir disoproxil fumarate for prevention of HIV infection in women: a phase 2, double-blind, randomized, placebo-controlled trial. PLoS Clin Trials 2007; 2:e27. These are the first clinical data for the much-hyped TDF for pre-exposure prophylaxis indication. No major toxicities were observed during the 1-year study. No differences in HIV transmission were observed in TDF recipients versus placebo.
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Peterson L, Taylor D, Roddy R, et al. Tenofovir disoproxil fumarate for prevention of HIV infection in women: a phase 2, double-blind, randomized, placebo-controlled trial. PLoS Clin Trials 2007; 2:e27. These are the first clinical data for the much-hyped TDF for pre-exposure prophylaxis indication. No major toxicities were observed during the 1-year study. No differences in HIV transmission were observed in TDF recipients versus placebo.
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Chi BH, Sinkala M, Mbewe F, et al. Single-dose tenofovir and emtricitabine for reduction of viral resistance to nonnucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet 2007; 370:1698-1705. This paper identifies an interesting new potential indication for TDF/emtricitabine as a single dose in mothers along with nevirapine to prevent nevirapine resistance. Additional research of this strategy is warranted, given the results of this study.
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Chi BH, Sinkala M, Mbewe F, et al. Single-dose tenofovir and emtricitabine for reduction of viral resistance to nonnucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet 2007; 370:1698-1705. This paper identifies an interesting new potential indication for TDF/emtricitabine as a single dose in mothers along with nevirapine to prevent nevirapine resistance. Additional research of this strategy is warranted, given the results of this study.
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CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related
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Kakuda TN, Anderson PL, Becker SL. CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related. AIDS 2004; 18:2442-2444.
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AIDS
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Kakuda, T.N.1
Anderson, P.L.2
Becker, S.L.3
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60
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Panel on Antiretroviral Guidelines for Adult and Adolescents, Washington, Distric of Columbia, USA: Department of Health and Human Services;, Accessed 13 February 2008
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Panel on Antiretroviral Guidelines for Adult and Adolescents. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. Washington, Distric of Columbia, USA: Department of Health and Human Services; 2006. http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf [Accessed 13 February 2008].
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(2006)
Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
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61
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In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA
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Mallon PW, Unemori P, Sedwell R, et al. In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA. J Infect Dis 2005; 191:1686-1696.
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J Infect Dis
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Mallon, P.W.1
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Meng Q, Olivero OA, Fasco MJ, et al. Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs. Environ Mol Mutagen 2007; 48 (3-4):307-321. This important work elucidates the potential effects of NRTIs on cellular DNA in vivo. It should be noted that this article is one of several articles devoted to this topic, which appear together in this journal issue.
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Meng Q, Olivero OA, Fasco MJ, et al. Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs. Environ Mol Mutagen 2007; 48 (3-4):307-321. This important work elucidates the potential effects of NRTIs on cellular DNA in vivo. It should be noted that this article is one of several articles devoted to this topic, which appear together in this journal issue.
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63
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Treating HIV during pregnancy: An update on safety issues
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Watts DH. Treating HIV during pregnancy: an update on safety issues. Drug Saf 2006; 29:467-490.
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Drug Saf
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Assessment of birth defects according to maternal therapy among infants in the Women and Infants Transmission Study
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Watts DH, Li D, Handelsman E, et al. Assessment of birth defects according to maternal therapy among infants in the Women and Infants Transmission Study. J Acquir Immune Defic Syndr 2007; 44:299-305.
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J Acquir Immune Defic Syndr
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Watts, D.H.1
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