메뉴 건너뛰기




Volumn 47, Issue 3, 2008, Pages 298-303

Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients

Author keywords

Human organic anion transporter 1; Intracellular tenofovir; Multidrug resistance protein 2; Multidrug resistance protein 4; Pharmacokinetics; Tenofovir diphosphate

Indexed keywords

ABACAVIR; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; MEMBRANE PROTEIN; NEVIRAPINE; PROTEIN ABCC2; PROTEIN ABCC4; PROTEIN SLC22A6; PROTEINASE INHIBITOR; STAVUDINE; TENOFOVIR; TENOFOVIR DISOPROXIL; ZIDOVUDINE; ABCC4 PROTEIN, HUMAN; ADENINE; CARRIER PROTEIN; DRUG DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; ORGANIC ANION TRANSPORTER 1; PHOSPHONIC ACID DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 42049090195     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31815e7478     Document Type: Article
Times cited : (140)

References (33)
  • 1
    • 33747041958 scopus 로고    scopus 로고
    • Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy
    • van Bommel F, Zollner B, Sarrazin C, et al. Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology. 2006;44:318-325.
    • (2006) Hepatology , vol.44 , pp. 318-325
    • van Bommel, F.1    Zollner, B.2    Sarrazin, C.3
  • 2
    • 42949167459 scopus 로고    scopus 로고
    • Findings from a double-blind, randomized, placebo-controlled trial of tenofovir disoproxil fumarate (TDF) for prevention of HIV-infection in women [ThLB0103]
    • Presented at:, Toronto
    • Peterson L, Taylor D, Clarke EEK, et al. Findings from a double-blind, randomized, placebo-controlled trial of tenofovir disoproxil fumarate (TDF) for prevention of HIV-infection in women [ThLB0103]. Presented at: XVI International AIDS Conference; 2006; Toronto.
    • (2006) XVI International AIDS Conference
    • Peterson, L.1    Taylor, D.2    Clarke, E.E.K.3
  • 3
    • 3242694930 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate: Clinical pharmacology and pharmacokinetics
    • Kearney BP, Flaherty JF, Shah J. Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics. Clin Pharmacokinet. 2004;43:595-612.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 595-612
    • Kearney, B.P.1    Flaherty, J.F.2    Shah, J.3
  • 4
    • 1442351728 scopus 로고    scopus 로고
    • The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities
    • Anderson PL, Kakuda TN, Lichtenstein KA. The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities. Clin Infect Dis. 2004;38:743-753.
    • (2004) Clin Infect Dis , vol.38 , pp. 743-753
    • Anderson, P.L.1    Kakuda, T.N.2    Lichtenstein, K.A.3
  • 5
    • 34249984379 scopus 로고    scopus 로고
    • The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: The first 4 years
    • Nelson MR, Katlama C, Montaner JS, et al. The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years. AIDS. 2007;21:1273-1281.
    • (2007) AIDS , vol.21 , pp. 1273-1281
    • Nelson, M.R.1    Katlama, C.2    Montaner, J.S.3
  • 6
    • 30144434319 scopus 로고    scopus 로고
    • Tenofovir-associated acute and chronic kidney disease: A case of multiple drug interactions
    • Zimmermann AE, Pizzoferrato T, Bedford J, et al. Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions. Clin Infect Dis. 2006;42:283-290.
    • (2006) Clin Infect Dis , vol.42 , pp. 283-290
    • Zimmermann, A.E.1    Pizzoferrato, T.2    Bedford, J.3
  • 7
    • 10744221111 scopus 로고    scopus 로고
    • Renal tubular dysfunction associated with tenofovir therapy: Report of 7 cases
    • Peyriere H, Reynes J, Rouanet I, et al. Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases. J Acquir Immune Defic Syndr. 2004;35:269-273.
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 269-273
    • Peyriere, H.1    Reynes, J.2    Rouanet, I.3
  • 8
    • 0037447180 scopus 로고    scopus 로고
    • Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: Three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus
    • Karras A, Lafaurie M, Furco A, et al. Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus. Clin Infect Dis. 2003;36:1070-1073.
    • (2003) Clin Infect Dis , vol.36 , pp. 1070-1073
    • Karras, A.1    Lafaurie, M.2    Furco, A.3
  • 9
    • 1542316361 scopus 로고    scopus 로고
    • Tenofovir-related nephrotoxicity: Case report and review of the literature
    • James CW, Steinhaus MC, Szabo S, et al. Tenofovir-related nephrotoxicity: case report and review of the literature. Pharmacotherapy. 2004;24:415-418.
    • (2004) Pharmacotherapy , vol.24 , pp. 415-418
    • James, C.W.1    Steinhaus, M.C.2    Szabo, S.3
  • 11
    • 0034852408 scopus 로고    scopus 로고
    • Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
    • Cihlar T, Ho ES, Lin DC, et al. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001;20:641-648.
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , pp. 641-648
    • Cihlar, T.1    Ho, E.S.2    Lin, D.C.3
  • 12
    • 33847001598 scopus 로고    scopus 로고
    • Multidrug resistance protein 2 (MRP2) inhibition by ritonavir increases TFV-associated cytotoxicity
    • abstract 23, Presented at: Québec City, Canada
    • Louie S, Lam JT, Neely M, et al. Multidrug resistance protein 2 (MRP2) inhibition by ritonavir increases TFV-associated cytotoxicity [abstract 23]. Presented at: Sixth International Workshop on Clinical Pharmacology of HIV Therapy; Québec City, Canada, 2005.
    • (2005) Sixth International Workshop on Clinical Pharmacology of HIV Therapy
    • Louie, S.1    Lam, J.T.2    Neely, M.3
  • 13
    • 30344432397 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites
    • Mallants R, Van Oosterwyck K, Van Vaeck L, et al. Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites. Xenobiotica. 2005;35:1055-1066.
    • (2005) Xenobiotica , vol.35 , pp. 1055-1066
    • Mallants, R.1    Van Oosterwyck, K.2    Van Vaeck, L.3
  • 14
    • 33846420624 scopus 로고    scopus 로고
    • Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir
    • Imaoka T, Kusuhara H, Adachi M, et al. Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007;71:619-627.
    • (2007) Mol Pharmacol , vol.71 , pp. 619-627
    • Imaoka, T.1    Kusuhara, H.2    Adachi, M.3
  • 15
  • 16
    • 22944433202 scopus 로고    scopus 로고
    • Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
    • Bleasby K, Hall LA, Perry JL, et al. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther. 2005;314:923-931.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 923-931
    • Bleasby, K.1    Hall, L.A.2    Perry, J.L.3
  • 17
    • 0036206860 scopus 로고    scopus 로고
    • Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: An association between single nucleotide polymorphisms in the 5′-untranslated region and exon 28
    • Itoda M, Saito Y, Soyama A, et al. Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5′-untranslated region and exon 28. Drug Metab Dispos. 2002;30:363-364.
    • (2002) Drug Metab Dispos , vol.30 , pp. 363-364
    • Itoda, M.1    Saito, Y.2    Soyama, A.3
  • 18
    • 33847249931 scopus 로고    scopus 로고
    • Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex
    • Haenisch S, Zimmermann U, Dazert E, et al. Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex. Pharmacogenomics J. 2007;7:56-65.
    • (2007) Pharmacogenomics J , vol.7 , pp. 56-65
    • Haenisch, S.1    Zimmermann, U.2    Dazert, E.3
  • 19
    • 0035103009 scopus 로고    scopus 로고
    • Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    • Ito S, Ieiri I, Tanabe M, et al. Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. Pharmacogenetics. 2001;11:175-184.
    • (2001) Pharmacogenetics , vol.11 , pp. 175-184
    • Ito, S.1    Ieiri, I.2    Tanabe, M.3
  • 20
    • 0033361943 scopus 로고    scopus 로고
    • Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
    • Toh S, Wada M, Uchiumi T, et al. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am J Hum Genet. 1999;64:739-746.
    • (1999) Am J Hum Genet , vol.64 , pp. 739-746
    • Toh, S.1    Wada, M.2    Uchiumi, T.3
  • 21
    • 33745929357 scopus 로고    scopus 로고
    • Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: A pilot study
    • Anderson PL, Lamba J, Aquilante CL, et al. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr. 2006;42:441-449.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 441-449
    • Anderson, P.L.1    Lamba, J.2    Aquilante, C.L.3
  • 22
    • 37349100297 scopus 로고    scopus 로고
    • The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients
    • June 20 [EPub ahead of print
    • Kiser JJ, Carten ML, Aquilante CL, et al. The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients. Clin Pharmacol Ther. 2007 June 20 [EPub ahead of print].
    • (2007) Clin Pharmacol Ther
    • Kiser, J.J.1    Carten, M.L.2    Aquilante, C.L.3
  • 23
    • 33750344235 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells
    • King T, Bushman L, Kiser J, et al. Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;843:147-156.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.843 , pp. 147-156
    • King, T.1    Bushman, L.2    Kiser, J.3
  • 25
    • 0033574249 scopus 로고    scopus 로고
    • A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group
    • Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130:461-470.
    • (1999) Ann Intern Med , vol.130 , pp. 461-470
    • Levey, A.S.1    Bosch, J.P.2    Lewis, J.B.3
  • 26
    • 0032879904 scopus 로고    scopus 로고
    • MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
    • Schuetz JD, Connelly MC, Sun D, et al. MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med. 1999;5:1048-1051.
    • (1999) Nat Med , vol.5 , pp. 1048-1051
    • Schuetz, J.D.1    Connelly, M.C.2    Sun, D.3
  • 27
    • 42949096192 scopus 로고    scopus 로고
    • Expression of nucleoside analog uptake transporters and entry mechanisms of AZT in immune cells
    • abstract 559, Presented at:, Los Angeles
    • Minuesa G, Purcet S, Erkizia I, et al. Expression of nucleoside analog uptake transporters and entry mechanisms of AZT in immune cells [abstract 559]. Presented at: 14th Conference on Retroviruses and Opportunistic Infections; 2007; Los Angeles.
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections
    • Minuesa, G.1    Purcet, S.2    Erkizia, I.3
  • 28
    • 33746822068 scopus 로고    scopus 로고
    • Effect of multidrug resistance proteins 2 and 4 polymorphisms on tenofovir pharmacokinetics in HIV-infected patients
    • abstract 34, Presented at:, Lisbon
    • Kiser JJ, Aquilante CL, Anderson PL, et al. Effect of multidrug resistance proteins 2 and 4 polymorphisms on tenofovir pharmacokinetics in HIV-infected patients [abstract 34]. Presented at: Seventh International Workshop on Clinical Pharmacology of HIV Therapy; 2006; Lisbon.
    • (2006) Seventh International Workshop on Clinical Pharmacology of HIV Therapy
    • Kiser, J.J.1    Aquilante, C.L.2    Anderson, P.L.3
  • 29
    • 33845226137 scopus 로고    scopus 로고
    • Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy
    • Izzedine H, Hulot JS, Villard E, et al. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. J Infect Dis. 2006;194:1481-1491.
    • (2006) J Infect Dis , vol.194 , pp. 1481-1491
    • Izzedine, H.1    Hulot, J.S.2    Villard, E.3
  • 30
    • 27944460405 scopus 로고    scopus 로고
    • Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP
    • Janneh O, Owen A, Chandler B, et al. Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP. AIDS. 2005;19:2097-2102.
    • (2005) AIDS , vol.19 , pp. 2097-2102
    • Janneh, O.1    Owen, A.2    Chandler, B.3
  • 32
    • 22344455482 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
    • Hawkins T, Veikley W, St. Claire RL 3rd, et al. Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. J Acquir Immune Defic Syndr. 2005;39:406-411.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 406-411
    • Hawkins, T.1    Veikley, W.2    St. Claire 3rd, R.L.3
  • 33
    • 0035179971 scopus 로고    scopus 로고
    • Replication validity of genetic association studies
    • Ioannidis JP, Ntzani EE, Trikalinos TA, et al. Replication validity of genetic association studies. Nat Genet. 2001;29:306-309.
    • (2001) Nat Genet , vol.29 , pp. 306-309
    • Ioannidis, J.P.1    Ntzani, E.E.2    Trikalinos, T.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.