Advances in anatomic, functional, and molecular imaging of angiogenesis

Journal of Nuclear Medicine

Volumn 49, Issue 4, 2008, Pages 511-514

  Hsu, Andrew R ^a   Chen, Xiaoyuan ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Dynamic contrast enhanced magnetic resonance imaging (DCE MRI); Integrin; Vascular endothelial growth factor receptor (VEGFR); Volumetric computed tomography (VCT)

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID CU 64; ANGIOGENESIS INHIBITOR; ARGINYLGLYCYLASPARTIC ACID; BEVACIZUMAB; CYTOTOXIC AGENT; FLUORODEOXYGLUCOSE F 18; INTEGRIN; RADIOISOTOPE; UNCLASSIFIED DRUG; VASCULOTROPIN 121; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; BREAST CANCER; CANCER RESEARCH; COLOR ULTRASOUND FLOWMETRY; COLORECTAL CANCER; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONFOCAL LASER MICROSCOPY; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DIGITAL SUBTRACTION ANGIOGRAPHY; FLUORESCENCE MICROSCOPY; HUMAN; LASER MICROSCOPY; LUNG NON SMALL CELL CANCER; MICROBUBBLE; MOLECULAR IMAGING; MULTIPHOTON MICROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SYNCHROTRON; ULTRASOUND;

ANIMALS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 42049088760     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.050179     Document Type: Review

References (36)

1. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-2342.
2. Engelke C, Schaefer-Prokop C, Schirg E, Freihorst J, Grubnic S, Prokop M. High-resolution CT and CT angiography of peripheral pulmonary vascular disorders. Radiographics. 2002;22:739-764.
3. Plouraboue F, Cloetens P, Fonta C, Steyer A, Lauwers F, Marc-Vergnes JP. X-ray high-resolution vascular network imaging. J Microsc. 2004;215:139-148.
4. Kiessling F, Greschus S, Lichy MP, et al. Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis. Nat Med. 2004;10:1133-1138.
5. Ferrara KW, Merritt CR, Burns PN, Foster FS, Mattrey RF, Wickline SA. Evaluation of tumor angiogenesis with US: imaging, Doppler, and contrast agents. Acad Radiol. 2000;7:824-839.
6. Brown EB, Campbell RB, Tsuzuki Y, et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 2001;7:864-868.
7. Jain RK, Munn LL, Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer. 2002;2:266-276.
8. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673-687.
9. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer. 2002;2:91-100.
10. Xiong JP, Stehle T, Zhang R, et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002;296:151-155.
11. Cai W, Rao J, Gambhir SS, Chen X. How molecular imaging is speeding up antiangiogenic drug development. Mol Cancer Ther. 2006;5:2624-2633.
12. 3. Biotechniques. 2005;39(suppl):S6-S17.
13. Liu S. Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging. Mol Pharm. 2006;3:472-487.
14. Haubner R. Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis? Eur J Nucl Med Mol Imaging. 2006;33(suppl 1):54-63.
15. Choe YS, Lee KH. Targeted in vivo imaging of angiogenesis: present status and perspectives. Curr Pharm Des. 2007;13:17-31.
16. Chen X. Multimodality imaging of tumor integrin alphavbeta3 expression. Mini Rev Med Chem. 2006;6:227-234.
17. 18F]galacto-RGD. PLoS Med. 2005;2:e70.
18. 18F-galacto-RGD PET. J Nucl Med. 2008;49:255-259.
19. 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression. J Nucl Med. 2006;47:763-769.
20. 18F-FDG. J Nucl Med. 2008;49:22-29.
21. 64Cu-labeled dimeric RGD peptides. Mol Imaging Biol. 2004;6:350-359.
22. Patterson BD, Abela R, Auderset H, et al. The materials science beamline at the Swiss Light Source: design and realization. Nucl Instrum Methods Phys Res A. 2005;540:42-67.
23. 18F-labeled dimeric RGD peptide. Mol Imaging. 2004;3:96-104.
24. 3 antagonists: recent developments. Curr Med Chem. 2005;12:51-70.
25. Kennedy JE, ter Haar GR, Wu F, et al. Contrast-enhanced ultrasound assessment of tissue response to high-intensity focused ultrasound. Ultrasound Med Biol. 2004;30:851-854.
26. 3 integrin expression. J Nucl Med. 2007;48:1162-1171.
27. Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. J Nucl Med. In press.
28. Cai W, Chen X. Nanoplatforms for targeted molecular imaging in living subjects. Small. 2007;3:1840-1854.
29. Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004;3:391-400.
30. 165) receptor scintigraphy. Ann Oncol. 2003;14:1274-1277.
31. 165): biodistribution, safety and radiation dosimetry in patients with pancreatic carcinoma. Q J Nucl Med Mol Imaging. 2004;48:198-206.
32. Cai W, Chen X. Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression. Front Biosci. 2007;12:4267-4279.
33. Cai W, Chen K, Mohamedali KA, et al. PET of vascular endothelial growth factor receptor expression. J Nucl Med. 2006;47:2048-2056.
34. Backer MV, Levashova Z, Patel V, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med. 2007;13:504-509.
35. Keyt BA, Nguyen HV, Berleau LT, et al. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors: generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem. 1996;271:5638-5646.
36. Wang H, Cai W, Chen K, et al. A new PET tracer specific for vascular endothelial growth factor receptor 2. Eur J Nucl Med Mol Imaging. 2007;34:2001-2010.