Converting human carbonic anhydrase II into a benzoate ester hydrolase through rational redesign

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 5, 2008, Pages 811-815

  Höst, Gunnar E ^a   Jonsson, Bengt Harald ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Carbonic anhydrase; Hydrolysis; Mutagenesis; Protein engineering; Rational design; Specificity

Indexed keywords

4 NITROPHENYLACETIC ACID; 4 NITROPHENYLBENZOATE; ACETIC ACID DERIVATIVE; BENZOATE ESTER HYDROLASE; BENZOIC ACID DERIVATIVE; CARBONATE DEHYDRATASE II; ENZYME VARIANT; HUMAN CARBONIC ANHYDRASE II; HYDROLASE; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; BINDING KINETICS; COMPARATIVE STUDY; HYDROLYSIS; MOLECULAR DOCKING; MUTATION; PREDICTION; PRIORITY JOURNAL;

CARBONIC ANHYDRASE II; CATALYSIS; ESTERASES; ESTERS; HUMANS; HYDROLYSIS; KINETICS; MUTANT PROTEINS; MUTATION; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 41949141811     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.02.007     Document Type: Article

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