Importance of Vitreous Liquefaction in Age-Related Cataract

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 1, 2004, Pages 77-85

  Harocopos, George J ^a   Shui, Ying Bo ^a   McKinnon, Megan ^a   Holekamp, Nancy M ^a   Gordon, Mae O ^a   Beebe, David C ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CATARACT; CATARACTOGENESIS; HUMAN; LENS; LIQUEFACTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VITREOUS BODY;

AGED; AGING; CATARACT; EYE DISEASES; HUMANS; LENS, CRYSTALLINE; MIDDLE AGED; SCLEROSIS; VITREOUS BODY;

EID: 0346727569     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0820     Document Type: Article

References (72)

1. Leske MC, Chylack LT Jr, Wu SY. The Lens Opacities Case-Control Study: risk factors for cataract. Arch Ophthalmol. 1991;109:244-251.
2. Leske MC, Chylack LT Jr, He Q, et al. Risk factors for nuclear opalescence in a longitudinal study: LSC Group - Longitudinal Study of Cataract. Am J Epidemiol. 1998;147:36-41.
3. Risk factors associated with age-related nuclear and cortical cataract: a case-control study in the Age-Related Eye Disease Study - AREDS Report No. 5. Ophthalmology 2001;108:1400-1408.
4. Wong TY, Klein BE, Klein R, Tomany SC, Lee KE. Refractive errors and incident cataracts: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci. 2001;42:1449-1454.
5. West SK, Duncan DD, Munoz B, et al. Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project. JAMA. 1998;280:714-718.
6. Taylor HR, West SK, Rosenthal FS, et al. Effect of ultraviolet radiation on cataract formation. N Engl J Med. 1988;319:1429-1433.
7. Delcourt C, Cristol JP, Tessier F, Leger CL, Michel F, Papoz L. Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study - Pathologies Oculaires Liees a l'Age. Am J Epidemiol. 2000;151:497-504.
8. Jobling AI, Augusteyn RC. What causes steroid cataracts? - a review of steroid-induced posterior subcapsular cataracts. Clin Exp Optom. 2002;85:61-75.
9. Dische Z, Zil HA. Studies on the oxidation of cysteine to cystine in lens proteins during cataract formation. Am J Ophthalmol. 1951;34:104-113.
10. Lou MF, Huang QL, Zigler JS Jr. Effect of opacification and pigmentation on human lens protein thiol/disulfide and solubility. Curr Eye Res. 1989;8:883-890.
11. Reddy V. Glutathione and its function in the lens: an overview. Exp Eye Res. 1990;50:771-778.
12. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995;9:1173-1182.
13. Truscott RJ, Augusteyn RC. Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim Biophys Acta. 1977;492:43-52.
14. Sweeney MH, Truscott RJ. An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res. 1998;67:587-595.
15. Moffat BA, Landman KA, Truscott RJ, Sweeney MH, Pope JM. Age-related changes in the kinetics of water transport in normal human lenses. Exp Eye Res. 1999;69:663-669.
16. Truscott RJ. Age-related nuclear cataract: A lens transport problem. Ophthalmic Res. 2000;32:185-194.
17. Margherio RR, Cox MS Jr, Trese MT, Murphy PL, Johnson J, Minor LA. Removal of epimacular membranes. Ophthalmology. 1985;92:1075-1083.
18. Melberg NS, Thomas MA. Nuclear sclerotic cataract after vitrectomy in patients younger than 50 years of age. Ophthalmology. 1995;102:1466-1471.
19. Novak MA, Rice TA, Michels RG, Auer C. The crystalline lens after vitrectomy for diabetic retinopathy. Ophthalmology. 1984;91:1480-1484.
20. Cherfan GM, Michels RG, de Bustros S, Enger C, Glaser BM. Nuclear sclerotic cataract after vitrectomy for idiopathic epiretinal membranes causing macular pucker. Am J Ophthalmol. 1991;111:434-438.
21. de Bustros S, Thompson JT, Michels RG, Enger C, Rice TA, Glaser BM. Nuclear sclerosis after vitrectomy for idiopathic epiretinal membranes. Am J Ophthalmol. 1988;105:160-164.
22. Ogura Y, Kitagawa K, Ogino N. Prospective longitudinal studies on lens changes after vitrectomy: quantitative assessment by fluorophotometry and refractometry [in Japanese]. Nippon Ganka Gakkai Zasshi. 1993;97:627-631.
23. Thompson JT, Glaser BM, Sjaarda RN, Murphy RP. Progression of nuclear sclerosis and long-term visual results of vitrectomy with transforming growth factor beta-2 for macular holes. Am J Ophthalmol. 1995;119:48-54.
24. Van Effenterre G, Ameline B, Campinchi F, Quesnot S, Le Mer Y, Haut J. Is vitrectomy cataractogenic?-study of changes of the crystalline lens after surgery of retinal detachment. J Fr Ophtalmol. 1992;15:449-454.
25. Hsuan JD, Brown NA, Bron AJ, Patel CK, Rosen PH. Posterior subcapsular and nuclear cataract after vitrectomy. J Cataract Refract Surg. 2001;27:437-444.
26. Sawa M, Saito Y, Hayashi A, Kusaka S, Ohji M, Tano Y. Assessment of nuclear sclerosis after nonvitrectomizing vitreous surgery. Am J Ophthalmol. 2001;132:356-362.
27. Salto Y, Lewis JM, Park I, et al. Nonvitrectomizing vitreous surgery: a strategy to prevent postoperative nuclear sclerosis. Ophthalmology. 1999;106:1541-1545.
28. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res. 2000;19:323-344.
29. Morita H, Funata M, Tokoro T. A clinical study of the development of posterior vitreous detachment in high myopia. Retina. 1995;15:117-124.
30. Stirpe M, Heimann K. Vitreous changes and retinal detachment in highly myopic eyes. Eur J Ophthalmol. 1996;6:50-58.
31. Lim R, Mitchell P, Cumming RG. Refractive associations with cataract: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci. 1999;40:3021-3026.
32. Ettl A, Fischer-Klein C, Chemelli A, Daxer A, Felber S. Proton relaxation times of the vitreous body in hereditary vitreoretinal dystrophy. Ophthalmologica. 1994;208:195-197.
33. Seery CM, Pruett RC, Liberfarb RM, Cohen BZ. Distinctive cataract in the Stickler syndrome. Am J Ophthalmol. 1990;110:143-148.
34. Balazs EA, Denlinger JL. Aging changes in the vitreus. In: Sekuler R, Kline D, Dismukes K, eds. Aging and Human Visual Function. New York: A. R. Liss; 1982;45-57.
35. Sebag J, Balazs EA. Morphology and ultrastructure of human vitreous fibers. Invest Ophthalmol Vis Sci. 1989;30:1867-1871.
36. Sebag J. Age-related changes in human vitreous structure. Graefes Arch Clin Exp Ophthalmol. 1987;225:89-93.
37. Los LI, van der Worp RJ, van Luyn MJA, Hooymans JMM. Age-related liquefaction of the human vitreous body: LM and TEM evaluation of the role of proteoglycans and collagen. Invest Ophthalmol Vis Sci. 2003;44:2828-2833.
38. Balazs EA, Denlinger JL. The vitreous. In: Davson H, ed. The Eye. London: Academic Press; 1982;533-589.
39. O'Malley P. The pattern of vitreous syneresis: a study of 800 autopsy eyes. In: Irvine AR, O'Malley C, eds. Advances in Vitreous Surgery. Springfield, IL: Thomas; 1976;17-33.
40. Vaughan-Thomas A, Gilbert SJ, Duance VC. Elevated levels of proteolytic enzymes in the aging human vitreous. Invest Ophthalmol Vis Sci. 2000;41:3299-3304.
41. Brown DJ, Bishop P, Hamdi H, Kenney MC. Cleavage of structural components of mammalian vitreous by endogenous matrix metalloproteinase-2. Curr Eye Res. 1996;15:439-445.
42. Brown D, Hamdi H, Bahri S, Kenney MC. Characterization of an endogenous metalloproteinase in human vitreous. Curr Eye Res. 1994;13:639-647.
43. Akiba J, Ueno N, Chakrabarti B. Age-related changes in the molecular properties of vitreous collagen. Curr Eye Res. 1993;12:951-954.
44. Chylack LT Jr, Wolfe JK, Singer DM, et al. The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111:831-836.
45. Roth AM, Foos RY. A system for the macroexamination of eyes in the laboratory. Am J Clin Pathol. 1973;59:674-683.
46. Sebag J, Ansari RR, Dunker S, Suh KI. Dynamic light scattering of diabetic vitreopathy. Diabetes Technol Ther. 1999;1:169-176.
47. Kishi S, Hagimura N, Shimizu K. The role of the premacular liquefied pocket and premacular vitreous cortex in idiopathic macular hole development. Am J Ophthalmol. 1996;122:622-628.
48. Kakehashi A, Schepens CL, Trempe CL. Vitreomacular observations. II. Data on the pathogenesis of idiopathic macular breaks. Graefes Arch Clin Exp Ophthalmol. 1996;234:425-433.
49. Freeman HM. Fellow eyes of giant retinal breaks. Trans Am Ophthalmol Soc. 1978;76:343-382.
50. Rosen E. Vitreous detachment associated with nuclear sclerosis. Am J Ophthalmol. 1962;54:837-841.
51. Foos RY, Wheeler NC. Vitreoretinal juncture: synchysis senilis and posterior vitreous detachment. Ophthalmology. 1982;89:1502-1512.
52. McCarty CA, Taylor HR. Recent developments in vision research: light damage in cataract. Invest Ophthalmol Vis Sci. 1996;37:1720-1723.
53. Alder VA, Cringle SJ. The effect of the retinal circulation on vitreal oxygen tension. Curr Eye Res. 1985;4:121-129.
54. Alder VA, Yu DY, Cringle SJ. Vitreal oxygen tension measurements in the rat eye. Exp Eye Res. 1991;52:293-299.
55. Alder VA, Cringle SJ. Vitreal and retinal oxygenation. Graefes Arch Clin Exp Ophthalmol. 1990;228:151-157.
56. Maeda N, Tano Y. Intraocular oxygen tension in eyes with proliferative diabetic retinopathy with and without vitreous. Graefes Arch Clin Exp Ophthalmol. 1996;234(suppl 1):S66-S69.
57. Sakaue H, Negi A, Honda Y. Comparative study of vitreous oxygen tension in human and rabbit eyes. Invest Ophthalmol Vis Sci. 1989;30:1933-1937.
58. Helbig H, Hinz JP, Kellner U, Foerster MH. Oxygen in the anterior chamber of the human eye. Ger J Ophthalmol. 1993;2:161-164.
59. Stefansson E, Novack RL, Hatchell DL. Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion. Invest Ophthalmol Vis Sci. 1990;31:284-289.
60. Avunduk AM, Cetinkaya K, Kapicioglu Z, Kaya C. The effect of posterior vitreous detachment on the prognosis of branch retinal vein occlusion. Acta Ophthalmol Scand. 1997;75:441-442.
61. Tachi N, Hashimoto Y, Ogino N. Vitrectomy for macular edema combined with retinal vein occlusion. Doc Ophthalmol. 1999;97:465-469.
62. Palmquist BM, Philipson B, Barr PO. Nuclear cataract and myopia during hyperbaric oxygen therapy. Br J Ophthalmol. 1984;68:113-117.
63. Lyne AJ. Ocular effects of hyperbaric oxygen. Trans Ophthalmol Soc UK. 1978;98:66-68.
64. Ross ME, Yolton DP, Yolton RL, Hyde KD. Myopia associated with hyperbaric oxygen therapy. Optom Vis Sci. 1996;73:487-494.
65. Giblin FJ, Schrimscher L, Chakrapani B, Reddy VN. Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level. Invest Ophthalmol Vis Sci. 1988;29:1312-1319.
66. Giblin FJ, Padgaonkar VA, Leverenz VR, et al. Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygen. Exp Eye Res. 1995;60:219-235.
67. Padgaonkar VA, Lin LR, Leverenz VR, Rinke A, Reddy VN, Giblin FJ. Hyperbaric oxygen in vivo accelerates the loss of cytoskeletal proteins and MIP26 in guinea pig lens nucleus. Exp Eye Res. 1999;68:493-504.
68. Borchman D, Giblin FJ, Leverenz VR, et al. Impact of aging and hyperbaric oxygen in vivo on guinea pig lens lipids and nuclear light scatter. Invest Ophthalmol Vis Sci. 2000;41:3061-3073.
69. Augusteyn RC. On the possible role of glutathione in maintaining human lens protein sulphydryls. Exp Eye Res. 1979;28:665-671.
70. Pau H, Graf P, Sies H. Glutathione levels in human lens: regional distribution in different forms of cataract. Exp Eye Res. 1990;50:17-20.
71. Giblin FJ. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther. 2000;16:121-135.
72. Xie P, Kanai A, Nakajima A, Kitahara S, Ohtsu A, Fujii K. Glutathione and glutathione-related enzymes in human cataractous lenses. Ophthalmic Res. 1991;23:133-140.