Supersensitivity to μ-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Gα protein subunits

Neuropharmacology

Volumn 54, Issue 6, 2008, Pages 989-997

  Mostany, Ricardo ^a   Díaz, Álvaro ^a   Valdizán, Elsa M ^a   Rodríguez Muñoz, María ^b   Garzón, Javier ^b   Hurlé, María A ^a,c  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b INSTITUTO CAJAL   (Spain)

^c IFIMAV   (Spain)

Author keywords

Opioids; Adenylyl cyclase; Analgesia; Calcium antagonist; G protein; Nociception; Opioid supersensitivity; Opioid tolerance

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORSKOLIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NIMODIPINE; PERTUSSIS TOXIN; PROTEIN G; RECEPTOR SUBUNIT; SUFENTANIL;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG POTENTIATION; DRUG TOLERANCE; ENZYME INHIBITION; LONG TERM CARE; LUMBAR SPINAL CORD; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SUPERSENSITIVITY;

ADENYLATE CYCLASE; ANALGESICS, OPIOID; ANIMALS; CALCIUM CHANNEL BLOCKERS; CYCLIC AMP; DATA INTERPRETATION, STATISTICAL; DRUG TOLERANCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IMMUNOPRECIPITATION; INFUSIONS, INTRAVENOUS; MALE; NIMODIPINE; PAIN MEASUREMENT; PAIN THRESHOLD; PERTUSSIS TOXIN; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; SUFENTANIL;

EID: 41949099751     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.02.004     Document Type: Article

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