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Volumn 50, Issue 3, 2008, Pages 303-312

Safety assessment of 2-ethyl-3,(5 or 6) dimethylpyrazine as a food ingredient

Author keywords

(5 or 6) Dimethylpyrazine; 2 Ethyl 3; Burdock; Food additive; GRAS; Toxicity

Indexed keywords

2 ETHYL 3,5 DIMETHYLPYRAZINE; 2 ETHYL 3,6 DIMETHYLPYRAZINE; FOOD ADDITIVE; UNCLASSIFIED DRUG;

EID: 41949098803     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2007.12.007     Document Type: Article
Times cited : (12)

References (76)
  • 3
    • 0034836499 scopus 로고    scopus 로고
    • Effect of pH, temperature, and moisture on the formation of volatile compounds in glycine/glucose model systems
    • Ames J.M., Guy R.C.E., and Kipping G.J. Effect of pH, temperature, and moisture on the formation of volatile compounds in glycine/glucose model systems. Journal of Agricultural and Food Chemistry 49 (2001) 4315-4323
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , pp. 4315-4323
    • Ames, J.M.1    Guy, R.C.E.2    Kipping, G.J.3
  • 4
    • 0037763735 scopus 로고
    • Gower Publication, Brookfield, VT p. 463
    • Ash M., and Ash I. 2-Ethyl-3,5(6)-dimethylpyrazine. Handbook of Food Additives (1995), Gower Publication, Brookfield, VT p. 463
    • (1995) Handbook of Food Additives
    • Ash, M.1    Ash, I.2
  • 5
    • 41949125742 scopus 로고    scopus 로고
    • TNO Nutrition and Food Research, Boelens Aroma Chemical Information Service, The Netherlands CD-ROM
    • BACIS. 2-Ethyl-3,5-dimethylpyrazine. Database of Volatile Compounds in Food (1999), TNO Nutrition and Food Research, Boelens Aroma Chemical Information Service, The Netherlands CD-ROM
    • (1999) Database of Volatile Compounds in Food
    • BACIS1
  • 7
    • 0027411633 scopus 로고
    • Effect of ph on pyrazine formation in glucose-glycine model systems
    • Bemis-Young G.L., Huang J., and Bernhard R.A. Effect of ph on pyrazine formation in glucose-glycine model systems. Food Chemistry 46 (1993) 383-387
    • (1993) Food Chemistry , vol.46 , pp. 383-387
    • Bemis-Young, G.L.1    Huang, J.2    Bernhard, R.A.3
  • 8
    • 0038216749 scopus 로고
    • Pyrazines produced by two bacteria responsible for the potato-like off-odor isolated from raw ham
    • Blanco D., Barbieri G., Dellapina G., and Bolzoni L. Pyrazines produced by two bacteria responsible for the potato-like off-odor isolated from raw ham. Microbiologie Aliments Nutrition 12 (1994) 413-422
    • (1994) Microbiologie Aliments Nutrition , vol.12 , pp. 413-422
    • Blanco, D.1    Barbieri, G.2    Dellapina, G.3    Bolzoni, L.4
  • 9
    • 0002094296 scopus 로고
    • Evaluation of the contribution of flavor volatiles to the aroma of beef by surface response methodology
    • Bodrero K.O., Pearson A.M., and Magee W.T. Evaluation of the contribution of flavor volatiles to the aroma of beef by surface response methodology. Journal of Food Science 46 (1981) 26-31
    • (1981) Journal of Food Science , vol.46 , pp. 26-31
    • Bodrero, K.O.1    Pearson, A.M.2    Magee, W.T.3
  • 10
    • 0006689348 scopus 로고
    • Regioselective synthesis of alkylpyrazines
    • Buechi G., and Galindo J. Regioselective synthesis of alkylpyrazines. Journal of Organic Chemistry 56 (1991) 2605-2606
    • (1991) Journal of Organic Chemistry , vol.56 , pp. 2605-2606
    • Buechi, G.1    Galindo, J.2
  • 13
    • 0001484619 scopus 로고
    • Volatile flavor components of corn tortillas and related products
    • Buttery R.G., and Ling L.C. Volatile flavor components of corn tortillas and related products. Journal of Agricultural and Food Chemistry 43 (1995) 1878-1882
    • (1995) Journal of Agricultural and Food Chemistry , vol.43 , pp. 1878-1882
    • Buttery, R.G.1    Ling, L.C.2
  • 14
    • 0031073046 scopus 로고    scopus 로고
    • 2-Ethyl-3,5-dimethylpyrazine and 2-ethyl-3,6-dimethylpyrazine: odor thresholds in water solution
    • Buttery R.G., and Ling L.C. 2-Ethyl-3,5-dimethylpyrazine and 2-ethyl-3,6-dimethylpyrazine: odor thresholds in water solution. Lebensmittel-Wissenschaft und Technologie 30 (1997) 109-110
    • (1997) Lebensmittel-Wissenschaft und Technologie , vol.30 , pp. 109-110
    • Buttery, R.G.1    Ling, L.C.2
  • 17
    • 0001046537 scopus 로고    scopus 로고
    • Cerny, C., Grosch, W., 1994. Precursors of ethyldimethylpyrazine isomers and 2,3-diethyl-5-methylpyrazine formed in roasted beef. Zeitschrift Fuer Lebensmittel-untersuchung Und - forschung 198, 210-214 (in German).
    • Cerny, C., Grosch, W., 1994. Precursors of ethyldimethylpyrazine isomers and 2,3-diethyl-5-methylpyrazine formed in roasted beef. Zeitschrift Fuer Lebensmittel-untersuchung Und - forschung 198, 210-214 (in German).
  • 18
    • 41949088809 scopus 로고    scopus 로고
    • CFIA (site visited on 11/18/2003) CFIA Schedule V - Part 1. Canadian Food Inspection Agency. Available from: .
    • CFIA (site visited on 11/18/2003) CFIA Schedule V - Part 1. Canadian Food Inspection Agency. Available from: .
  • 19
    • 0007671045 scopus 로고    scopus 로고
    • Structure-odor relationships for bell-pepper, green and nutty notes in pyrazines and thiazoles. Comparison between neural networks and similarity searching
    • Chastrette M., El Aidi C., and Cretin D. Structure-odor relationships for bell-pepper, green and nutty notes in pyrazines and thiazoles. Comparison between neural networks and similarity searching. Environmental Research 7 (1997) 233-258
    • (1997) Environmental Research , vol.7 , pp. 233-258
    • Chastrette, M.1    El Aidi, C.2    Cretin, D.3
  • 20
    • 0031724479 scopus 로고    scopus 로고
    • Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation
    • Cho M.K., and Kim S.G. Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation. Chemico-Biological Interactions 116 (1998) 229-245
    • (1998) Chemico-Biological Interactions , vol.116 , pp. 229-245
    • Cho, M.K.1    Kim, S.G.2
  • 22
    • 12444335556 scopus 로고    scopus 로고
    • Council of Europe Publishing, Strasbourg Cedex, France p. 489
    • CoE. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. Chemically-Defined Flavouring Substances (2000), Council of Europe Publishing, Strasbourg Cedex, France p. 489
    • (2000) Chemically-Defined Flavouring Substances
    • CoE1
  • 23
    • 41949086260 scopus 로고    scopus 로고
    • CSFII 1994-96, 2000. Continuing survey of food intakes by individuals (CSFII) 1994-96, 98. Agricultural Research Service, US Department of Agriculture, Washington, DC. CD-ROM.
    • CSFII 1994-96, 2000. Continuing survey of food intakes by individuals (CSFII) 1994-96, 98. Agricultural Research Service, US Department of Agriculture, Washington, DC. CD-ROM.
  • 25
    • 0003446297 scopus 로고    scopus 로고
    • National Academy Press, Washington, DC p. 488-489
    • FCC. 2-Ethyl-3,5(6)-dimethylpyrazine. fourth ed. Food Chemicals Codex (1996), National Academy Press, Washington, DC p. 488-489
    • (1996) Food Chemicals Codex
    • FCC1
  • 26
    • 41949102059 scopus 로고    scopus 로고
    • FCC, 1997. 2-Ethyl-3,5(6)-dimethylpyrazine. In: Food Chemicals Codex. First Supplement to Fourth Edition, National Academy Press, Washington, DC, pp. 74-75.
    • FCC, 1997. 2-Ethyl-3,5(6)-dimethylpyrazine. In: Food Chemicals Codex. First Supplement to Fourth Edition, National Academy Press, Washington, DC, pp. 74-75.
  • 27
    • 41949090211 scopus 로고    scopus 로고
    • FDA, 1982. Toxicological principles for the safety assessment of direct food additives and color additives used in food ('Redbook'). US Food and Drug Administration, Washington, DC.
    • FDA, 1982. Toxicological principles for the safety assessment of direct food additives and color additives used in food ('Redbook'). US Food and Drug Administration, Washington, DC.
  • 28
    • 0021816471 scopus 로고
    • Alkylpyrazines, volatile formed in the Millard reaction I. Determination of odor detection threshold and odor intensity functions by dynamic olfactometry
    • Fors S., and Olofsson. Alkylpyrazines, volatile formed in the Millard reaction I. Determination of odor detection threshold and odor intensity functions by dynamic olfactometry. Chemical Senses 10 (1985) 287-296
    • (1985) Chemical Senses , vol.10 , pp. 287-296
    • Fors, S.1    Olofsson2
  • 30
    • 0032722409 scopus 로고    scopus 로고
    • Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice
    • Gaworski C.L., Heck J.D., Bennett M.B., and Wenk M.L. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology 139 (1999) 1-17
    • (1999) Toxicology , vol.139 , pp. 1-17
    • Gaworski, C.L.1    Heck, J.D.2    Bennett, M.B.3    Wenk, M.L.4
  • 31
    • 1542772697 scopus 로고
    • Characterization of meat and bone meal flavor volatiles
    • Greenberg M.J. Characterization of meat and bone meal flavor volatiles. Journal of Agricultural and Food Chemistry 29 (1981) 1276-1280
    • (1981) Journal of Agricultural and Food Chemistry , vol.29 , pp. 1276-1280
    • Greenberg, M.J.1
  • 33
    • 41949138607 scopus 로고    scopus 로고
    • Guadagni, D.G., Buttery, R.G., 1974. Method of imparting fatty-fried flavor to foods and composition. In United States Patent. NTIS, Report No.: PB-247 885/7/XAB.
    • Guadagni, D.G., Buttery, R.G., 1974. Method of imparting fatty-fried flavor to foods and composition. In United States Patent. NTIS, Report No.: PB-247 885/7/XAB.
  • 35
    • 0024325368 scopus 로고    scopus 로고
    • Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system
    • Hahnemann B., Legrum W., Koss G., and Netter K.J. Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system. Xenobiotica 19 (1999) 1319-1326
    • (1999) Xenobiotica , vol.19 , pp. 1319-1326
    • Hahnemann, B.1    Legrum, W.2    Koss, G.3    Netter, K.J.4
  • 36
    • 41949142041 scopus 로고
    • Recent progress in the consideration of flavoring ingredients under the food additives amendment IV GRAS substances. 2-Ethyl-3,5 or 6-dimethylpyrazine
    • Hall R.L., and Oser B.L. Recent progress in the consideration of flavoring ingredients under the food additives amendment IV GRAS substances. 2-Ethyl-3,5 or 6-dimethylpyrazine. Food Technology 24 (1970) 28
    • (1970) Food Technology , vol.24 , pp. 28
    • Hall, R.L.1    Oser, B.L.2
  • 37
    • 0016810415 scopus 로고
    • Metabolism in the rat of some pyrazine derivatives having flavour importance in foods
    • Hawksworth G., and Scheline R.R. Metabolism in the rat of some pyrazine derivatives having flavour importance in foods. Xenobiotica 5 (1975) 389-399
    • (1975) Xenobiotica , vol.5 , pp. 389-399
    • Hawksworth, G.1    Scheline, R.R.2
  • 39
    • 41949104242 scopus 로고    scopus 로고
    • IOFI, 1995. International Organization of the Flavor Industry (IOFI). European inquiry on volume use. Private communication to the Flavor and Extract Manufacturers' Association (FEMA) (cited in Adams et al. 2002).
    • IOFI, 1995. International Organization of the Flavor Industry (IOFI). European inquiry on volume use. Private communication to the Flavor and Extract Manufacturers' Association (FEMA) (cited in Adams et al. 2002).
  • 41
    • 41949126905 scopus 로고    scopus 로고
    • JECFA, 2001. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. In: Compendium of Food Additive Specifications. Food and Nutrition Paper 52. Addendum 9. Food and Agricultural Organization of the United Nations, Rome, Italy, pp. 128-129.
    • JECFA, 2001. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. In: Compendium of Food Additive Specifications. Food and Nutrition Paper 52. Addendum 9. Food and Agricultural Organization of the United Nations, Rome, Italy, pp. 128-129.
  • 42
    • 0028060141 scopus 로고
    • Antimutagenicity of Maillard reaction products from amino acid/sugar model systems against 2-amino-3-methylimidazo-(4,5-f) quinoline: The role of pyrazines
    • Jenq S., Tsai S.H., and Lee H. Antimutagenicity of Maillard reaction products from amino acid/sugar model systems against 2-amino-3-methylimidazo-(4,5-f) quinoline: The role of pyrazines. Mutagenesis 9 (1994) 483-488
    • (1994) Mutagenesis , vol.9 , pp. 483-488
    • Jenq, S.1    Tsai, S.H.2    Lee, H.3
  • 43
    • 10244247217 scopus 로고
    • Effect of microwave heating on pyrazine formation in a model system
    • Ji H., and Bernhard R.A. Effect of microwave heating on pyrazine formation in a model system. Journal of Science Food and Agriculture 59 (1992) 283-289
    • (1992) Journal of Science Food and Agriculture , vol.59 , pp. 283-289
    • Ji, H.1    Bernhard, R.A.2
  • 45
    • 84987357452 scopus 로고
    • Odor threshold levels of pyrazine compounds and assessment of their role in the flavor of roasted foods
    • Koehler P.E., Mason M.E., and Odell G.V. Odor threshold levels of pyrazine compounds and assessment of their role in the flavor of roasted foods. Journal of Food Science 36 (1971) 816-818
    • (1971) Journal of Food Science , vol.36 , pp. 816-818
    • Koehler, P.E.1    Mason, M.E.2    Odell, G.V.3
  • 46
    • 0027993681 scopus 로고
    • Antiplatelet structure-activity relationship of tetramethylpyrazine
    • Liu S.Y., and Sylvester D.M. Antiplatelet structure-activity relationship of tetramethylpyrazine. Life Science 55 (1994) 1317-1326
    • (1994) Life Science , vol.55 , pp. 1317-1326
    • Liu, S.Y.1    Sylvester, D.M.2
  • 47
    • 41949122640 scopus 로고    scopus 로고
    • Lucas, C.D., Putnam, J.M., Hallagan, J.B., 1999. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. In: 1995 Poundage and Technical Effects Update Survey. Flavor and Extract Manufacturers' Association of the United States, Washington, DC, p. 106.
    • Lucas, C.D., Putnam, J.M., Hallagan, J.B., 1999. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. In: 1995 Poundage and Technical Effects Update Survey. Flavor and Extract Manufacturers' Association of the United States, Washington, DC, p. 106.
  • 49
    • 41949101779 scopus 로고    scopus 로고
    • Mattia, A., Renwick, A.G., Sipes, I.G., 2001. Safety evaluation of certain food additives and contaminants. Pyrazine derivatives. WHO Food Additives Series: 48.
    • Mattia, A., Renwick, A.G., Sipes, I.G., 2001. Safety evaluation of certain food additives and contaminants. Pyrazine derivatives. WHO Food Additives Series: 48.
  • 50
    • 0011915913 scopus 로고
    • The mechanism of pyrrole, pyrazine and pyridine formation in non-enzymic browning reaction
    • Milic B.L., and Piletic M.V. The mechanism of pyrrole, pyrazine and pyridine formation in non-enzymic browning reaction. Food Chemistry 13 (1984) 165-180
    • (1984) Food Chemistry , vol.13 , pp. 165-180
    • Milic, B.L.1    Piletic, M.V.2
  • 52
    • 41949094350 scopus 로고    scopus 로고
    • MRCA, 1965. Market Research Corporation of America (MRCA), in conjunction with the "Food intake and nutritive value of the diets of men, women and children in United States, Spring 1965". In: A Preliminary Report by the Consumer and Food Economics Research Division, Agricultural Research Division. United States Department of Agriculture, Washington, DC.
    • MRCA, 1965. Market Research Corporation of America (MRCA), in conjunction with the "Food intake and nutritive value of the diets of men, women and children in United States, Spring 1965". In: A Preliminary Report by the Consumer and Food Economics Research Division, Agricultural Research Division. United States Department of Agriculture, Washington, DC.
  • 53
    • 41949083188 scopus 로고    scopus 로고
    • NACGM, 1977. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. National Association of Chewing Gum Manufacturers, Mt. Laurel, NJ, personal communication.
    • NACGM, 1977. 2-Ethyl-3,(5 or 6)-dimethylpyrazine. National Association of Chewing Gum Manufacturers, Mt. Laurel, NJ, personal communication.
  • 54
  • 55
    • 41949095288 scopus 로고    scopus 로고
    • Oser, B.L., 1969a. 90-day feeding study with 2-ethyl,3,5(6)-dimethyl pyrazine in rats. Submmited to WHO by the Flavor and Extract Manufacturer's Association (cited in Adams et al. 2002).
    • Oser, B.L., 1969a. 90-day feeding study with 2-ethyl,3,5(6)-dimethyl pyrazine in rats. Submmited to WHO by the Flavor and Extract Manufacturer's Association (cited in Adams et al. 2002).
  • 56
    • 41949091467 scopus 로고    scopus 로고
    • Oser, B.L., 1969b. The acute oral toxicity to rats of nine pyrazine derivatives. Submitted to WHO by the Flavor and Extract Manufacturers' Association (cited in Adams et al. 2002).
    • Oser, B.L., 1969b. The acute oral toxicity to rats of nine pyrazine derivatives. Submitted to WHO by the Flavor and Extract Manufacturers' Association (cited in Adams et al. 2002).
  • 60
    • 0010591535 scopus 로고
    • Effect of time, temperature, and reactant ratio on pyrazine formation in model systems
    • Shibamoto T., and Bernhard R.A. Effect of time, temperature, and reactant ratio on pyrazine formation in model systems. Journal of Agricultural and Food Chemistry 24 (1976) 847-852
    • (1976) Journal of Agricultural and Food Chemistry , vol.24 , pp. 847-852
    • Shibamoto, T.1    Bernhard, R.A.2
  • 62
    • 0342297804 scopus 로고
    • A study of the volatiles isolated from a d-glucose-hydrogen sulfide-ammonia model system
    • Shibamoto T., and Russell G.F. A study of the volatiles isolated from a d-glucose-hydrogen sulfide-ammonia model system. Journal of Agricultural and Food Chemistry 25 (1977) 109-112
    • (1977) Journal of Agricultural and Food Chemistry , vol.25 , pp. 109-112
    • Shibamoto, T.1    Russell, G.F.2
  • 63
  • 64
    • 41949111228 scopus 로고    scopus 로고
    • Sigma-Aldrich (site visited on 11/18/2003). Material Safety Data Sheet on 2-ethyl-3,(5 or 6) dimethylpyrazine. .
    • Sigma-Aldrich (site visited on 11/18/2003). Material Safety Data Sheet on 2-ethyl-3,(5 or 6) dimethylpyrazine. .
  • 65
    • 0020319078 scopus 로고
    • Poly (adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes
    • Sims J.L., Sikorski G.W., Cationa D.M., Berger S.J., and Berger N.A. Poly (adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes. Biochemistry Journal 21 (1982) 1813-1821
    • (1982) Biochemistry Journal , vol.21 , pp. 1813-1821
    • Sims, J.L.1    Sikorski, G.W.2    Cationa, D.M.3    Berger, S.J.4    Berger, N.A.5
  • 67
    • 0019199015 scopus 로고
    • Mutagenic activity of pyrazine derivatives: a comparative study with Salmonella typhimurium, Saccharomyces cerevisiae and Chinese hamster ovary cells
    • Stich H.F., Stich W., Rosin M.P., and Powrie W.D. Mutagenic activity of pyrazine derivatives: a comparative study with Salmonella typhimurium, Saccharomyces cerevisiae and Chinese hamster ovary cells. Food and Cosmetics Toxicology 18 (1980) 581-584
    • (1980) Food and Cosmetics Toxicology , vol.18 , pp. 581-584
    • Stich, H.F.1    Stich, W.2    Rosin, M.P.3    Powrie, W.D.4
  • 68
    • 0002460382 scopus 로고
    • Consumption ratio and food predominance of flavoring materials
    • Stofberg J., and Grundschober F. Consumption ratio and food predominance of flavoring materials. Perfumer and Flavorist (1987) 12
    • (1987) Perfumer and Flavorist , pp. 12
    • Stofberg, J.1    Grundschober, F.2
  • 70
    • 33845971195 scopus 로고    scopus 로고
    • TNO Nutrition and Food Research Institute, The Netherlands p. 39-41
    • van Gemert L.J. Compilation of odor threshold values in air and water. Boelens Aroma Chemical Information Service (1999), TNO Nutrition and Food Research Institute, The Netherlands p. 39-41
    • (1999) Boelens Aroma Chemical Information Service
    • van Gemert, L.J.1
  • 71
    • 0006292426 scopus 로고
    • An evaluation of food flavoring ingredients using an in vivo reproductive and developmental toxicity screening test
    • (cited in Adams et al. 2002)
    • Vollmuth T.A., Bennett M.B., Hoberman A.M., and Christian M.S. An evaluation of food flavoring ingredients using an in vivo reproductive and developmental toxicity screening test. Teratology 41 (1990) 597 (cited in Adams et al. 2002)
    • (1990) Teratology , vol.41 , pp. 597
    • Vollmuth, T.A.1    Bennett, M.B.2    Hoberman, A.M.3    Christian, M.S.4
  • 73
    • 41949131829 scopus 로고    scopus 로고
    • Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of pregnant female rats
    • Yamada K., Sano M., and Aoyagi Y. Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of pregnant female rats. Japanese Journal of Pharmacology 88 (2002) 257
    • (2002) Japanese Journal of Pharmacology , vol.88 , pp. 257
    • Yamada, K.1    Sano, M.2    Aoyagi, Y.3
  • 74
    • 0028339726 scopus 로고
    • Effects of 2,5-dimethylpyrazine on plasmatestosterone and polyamines-and acid phosphatase-levels in the rat prostate
    • (cited in Adams et al. 2002)
    • Yamada K., Shimizu A., Komatsu H., Sakata R., and Ohta A. Effects of 2,5-dimethylpyrazine on plasmatestosterone and polyamines-and acid phosphatase-levels in the rat prostate. Biological & Pharmaceutical Bulletin 17 (1994) 730-731 (cited in Adams et al. 2002)
    • (1994) Biological & Pharmaceutical Bulletin , vol.17 , pp. 730-731
    • Yamada, K.1    Shimizu, A.2    Komatsu, H.3    Sakata, R.4    Ohta, A.5
  • 75
    • 0026603698 scopus 로고
    • Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive-organs in female rats
    • (cited in Adams et al. 2002)
    • Yamada K., Takahashi H., and Ohta A. Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive-organs in female rats. Research Communications in Chemical Pathology and Pharmacology 75 (1992) 99-107 (cited in Adams et al. 2002)
    • (1992) Research Communications in Chemical Pathology and Pharmacology , vol.75 , pp. 99-107
    • Yamada, K.1    Takahashi, H.2    Ohta, A.3
  • 76
    • 0031862302 scopus 로고    scopus 로고
    • Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of normal or pregnant female rats
    • Yamada K., Kobayashi Y., Fujihara H., and Ohta A. Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of normal or pregnant female rats. Biological & Pharmaceutical Bulletin 21 (2004) 538-540
    • (2004) Biological & Pharmaceutical Bulletin , vol.21 , pp. 538-540
    • Yamada, K.1    Kobayashi, Y.2    Fujihara, H.3    Ohta, A.4


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