Effect of levetiracetam on cortical excitability: A transcranial magnetic stimulation study

European Journal of Neurology

Volumn 15, Issue 5, 2008, Pages 501-505

  Solinas, C ^a   Lee, Y C ^a   Reutens, D C ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Cortical excitability; Cortical silent period; Levetiracetam; Resting motor threshold; Transcranial magnetic stimulation

Indexed keywords

ETIRACETAM;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFECT; ELECTROMYOGRAM; EVOKED CORTICAL RESPONSE; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR PERFORMANCE; NERVE EXCITABILITY; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; ANALYSIS OF VARIANCE; DIFFERENTIAL THRESHOLD; ELECTRIC STIMULATION; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; NEURAL INHIBITION; NOOTROPIC AGENTS; PIRACETAM; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 41849134292     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02110.x     Document Type: Article

References (25)

1. Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W. Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Annals of Neurology 1996 40 : 367 378.
2. Reutens DC, Berkovic SF, Macdonell RA, Bladin P. Magnetic stimulation of the brain in generalized epilepsy: reversal of cortical hyperexcitability by anticonvulsants. Annals of Neurology 1993 34 : 351 355.
3. Aguglia U, Gambardella A, Quartarone A, et al. Interhemispheric threshold differences in idiopathic generalized epilepsies with versive or circling seizures determined with focal magnetic transcranial stimulation. Epilepsy Research 2000 40 : 1 6.
4. Werhahn KJ, Kunesch E, Noachtar S, Benecke R, Classen J. Differential effects on motor cortical inhibition induced by blockade of GABA uptake in humans. Journal of Physiology 1999 517 (Pt 2 591 597.
5. Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W. The effect of lorazepam on the motor cortical excitability in man. Experimental Brain Research 1996 109 : 127 135.
6. Inghilleri M, Berardelli A, Marchetti P, Manfredi M. Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation in humans. Experimental Brain Research 1996 109 : 467 472.
7. Siebner HR, Dressnandt J, Auer C, Conrad B. Continuous intratechal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalised dystonia. Muscle and Nerve 1998 21 : 1209 1212.
8. Thompson SM, Gahwiler BH. Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. Journal of Neurophysiology 1992 67 : 1698 1701.
9. Lynch BA, Lambeng N, Nocka K, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proceedings of the National Academy of Sciences of the United States of America 2004 101 : 9861 9866.
10. Sohn YH, Kaelin-Lang A, Jung HY, Hallett M. Effect of levetiracetam on human corticospinal excitability. Neurology 2001 57 : 858 863.
11. Reis J, Wentrup A, Hamer HM, et al. Levetiracetam influences human motor cortex excitability mainly by modulation of ion channel function-a TMS study. Epilepsy Research 2004 62 : 41 51.
12. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971 9 : 97 113.
13. Mills KR, Boniface SJ, Schubert M. Magnetic brain stimulation with a double coil: the importance of coil orientation. Electroencephalography and Clinical Neurophysiology 1992 85 : 17 21.
14. Ricard MD, Ugrinowitsch C, Parcell AC, et al. Effects of rate of force development on EMG amplitude and frequency. International Journal of Sports Medicine 2005 26 : 6.
15. Ives JC, Wigglesworth JK. Sampling rate effects on surface EMG timing and amplitude measures. Clinical Biomechanics (Bristol, Avon) 2003 18 : 543 552.
16. Niespodziany I, Klitgaard H, Margineanu DG. LEV inhibits the high-voltage-activated Ca (2+) current in pyramidal neurones of rat hippocampal slices. Neuroscience Letters 2001 306 : 5 8.
17. Madeja M, Margineanu DG, Gorji A, et al. Reduction of voltage-operated potassium currents by LEV: a novel antiepileptic mechanism of action? Neuropharmacology 2003 45 : 661 671.
18. 2+ currents. Seizure 2001 10 : 279 286.
19. Noyer M, Gillard M, Matagne A, Henichart JP, Wulfert E. The novel antiepileptic drug LEV (ucb L059) appears to act via a specific binding site in CNS membranes. European Journal of Pharmacology 1995 286 : 137 146.
20. Rigo JM, Hans G, Nguyen L, et al. The anti-epileptic drug LEV reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. British Journal of Pharmacology 2002 136 : 659 672.
21. Nicoll RA, Malenka RC, Kauer JA. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiological Reviews 1990 70 : 513 565.
22. Chistyakov AV, Soustiel JF, Hafner H, Trubnik M, Levy G, Feinsod M. Excitatory and inhibitory corticospinal responses to transcranial magnetic stimulation in patients with minor to moderate head injury. Journal of Neurology, Neurosurgery and Psychiatry 2001 70 : 580 587.
23. Loo YL, Fook-Chong S. The silent period threshold as a measure of corticospinal inhibition. Journal of Clinical Neurophysiology 2005 22 : 176 179.
24. Davey NJ, Romaiguere P, Maskill DW, Ellaway PH. Suppression of voluntary motor activity revealed using transcranial magnetic stimulation of the motor cortex in man. Journal of Physiology 1994 477 (Pt 2 223 235.
25. Inghilleri M, Berardelli A, Cruccu G, Manfredi M. Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction. Journal of Physiology 1993 466 : 521 534.